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Tramol (Tramadol)

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Tramol is a centrally-acting opioid agonist and SNRI (serotonin/norepinephrine reuptake inhibitor) used for the management of moderate to severe pain in adults. Tramol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that is structurally related to codeine and morphine.

Other names for this medication:
Acuvin, Axedol, Cradol, Didol, Domadol, Drobit, Esgiypyrin, Euphodol, Madol, Mandol, Novadol, Ondol, Ramadol, Ramcet, Relidol, Ryzolt, Sedate, Tacil, Tamody, Tramabit, Tramache, Tramadex, Tramadol, Tramatas, Tramazac, Trambax, Tramest, Tramospas, Trandol, Trasic, Trazac, Tromar, Ubitdol, Vegadol, Zotadol

Similar Products:
Cozaar, Trileptal, Xeloda, Aygestin, Amaryl, Arcoxia, Calan, Celexa, Olinapril, Cetri, Neurograin, Zoryl, Fortagyl, Ectin,

Also known as: Tramadol


Tramol ER is an pain medicine similar to an opioid. This medicine is used to treat moderate to severe pain.

The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Tramol: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Tramol is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Tramol dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Tramol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Tramol if you are allergic to tramadol, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Tramol should not be given to a child younger than 12 years old. Tramol ER should not be given to anyone younger than 18 years old.

Do not give Tramol to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Tramol. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

To make sure Tramol is safe for you, tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use tramadol during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using tramadol if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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Surveys conducted in five areas of Southern Ontario obtained clinical and service utilization data from 5,478 adults over 25 years of age. The initial resistance index was increased in 1.2 due to the local venous congestion in only 15 min after the administration of gel. Iatrogenic prematurity is the most common pregnancy complication associated with malignancy in pregnancy because many of these infants are delivered early to facilitate maternal treatment. In order to evaluate the symptomatic efficacy of cisapride on motility disorders often associated with mild inflammatory changes of the upper gastrointestinal tract, the authors carried out a comparison between two groups of patients (15 patients in each group, 10 males and 5 females) with histologic antral gastritis, treated respectively with famotidine 40 mg/day per os plus cisapride 10 mg ter/die per os, and famotidine alone. There was no significant difference in posterior or superior translation between either reconstruction technique. The present investigation has demonstrated that PDE3A is the major cAMP-degrading PDE in the oocyte. Motivations, outcomes, and characteristics of unspecified (nondirected altruistic) kidney donors in the United Kingdom. Of the 16 dogs that were receiving chemotherapy or had allergic disease, 15 were treated for the demodicosis while still receiving treatment for their underlying disease: 1 was cured, 13 were improved but needed maintenance amitraz dips, and 1 did not improve and was euthanatized.

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A human gastric adenocarcinoma cell line (AGS) was overlaid with either cagA-positive or cagA-negative H. By 7 days, gfap and sgp-2 mRNAs were increased markedly in the peri-infarct area, and in the ipsilateral thalamus parallel with the delayed neuronal damage, whereas the widespread increase of gfap mRNA in the ipsilateral hemisphere declined. Storage of glycogen in the kidney was to be found in numerous treated animals whereby it was evident that the cells of the macula densa showed no storage. Only later does its expression become confined to the prospective and differentiating neural retina. Intrahemispheric connectivity from primary auditory cortex to STG was stronger in the left compared to the right hemisphere. Automated small-scale purification was adapted for two highly expressed proteins. VA users cared for in Medicare hospitals receive more cardiac procedures but have the same survival as VA users cared for in VAMCs. In response to these stresses, hepatocytes are primed, through the release of inflammatory cytokines, to increase the expression of immediate early genes and increase the activation of transcriptional factors. Associations between AAHC and other variables were tested in a multivariate model in 4 groups of women with adult EPSA, childhood EPSA, childhood and adult EPSA, and no EPSA.

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Monitoring recruitment success and cost in a randomized clinical trial. Hormonal induction of alpha-lactalbumin and beta-lactoglobulin in cultured mammary explants from pregnant pigs. In Part I of this survey, women were asked about their personal experiences with menopause, their health-related lifestyle changes since premenopause, their frequency of discussing menopause, and their rating of preparedness for menopause. Furthermore, there is also a need for a prospective study of QTc intervals in infants born to mothers receiving methadone. The oral glucose tolerance test (OGTT) and the euglycemic-hyperinsulinemic clamp (EHC) were performed to assess glucose tolerance and insulin sensitivity. Nationally representative survey data from 1987 and 2003 were used to examine the top medical conditions accounting for the rise in spending.

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Nonstationarity is an important aspect of imaging performance in CT and cone-beam CT (CBCT), especially for systems employing iterative reconstruction. The method was used to examine five microsatellite loci in eight species of Barbus (sensu lato). These findings extend the omission-commission model to schizophrenia and may have important implications for efficient assessment and effective rehabilitation of functional impairment, such as the potential efficacy of targeted interventions for the rehabilitation of omission and commission deficits in everyday functioning. Oxidative DNA damage correlates with oxygen consumption in humans. The variant cDNA lacks the sequence corresponding to the first 132 nucleotides of the third exon of the syndecan-1 gene. Systemic and local anti-OVA immune responses and intestinal barrier function were measured after 5 to 6 weeks. The mixed lymphocyte reactivity is depressed at mid-pregnancy, whereas PFC response is increased.

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Furthermore, tumor cells consistently displayed increased cetuximab resistance upon the addition of rhEGF, whereas EGF silencing was associated with an improved cetuximab response. Developing better methods to store microarray data can greatly improve the efficiency and usefulness of such data. Accountability: an overview of the impact of litigation on professionals. Therapeutic approaches: clinical testing of clofibrate (Lipavlon: I.C.I. Among 73 GBMs, 45 had been initially treated with temozolomide and radiation. Effect of different temporary immunosuppressive therapies and low-temperature culture on pancreatic islet xenograft survival (pig-to-mouse). In the younger group, verbal intelligence and processing speed contributed to phonemic fluency, semantic retrieval to semantic fluency, processing speed and working memory to excluded letter fluency, and semantic retrieval to alternating fluency. We have previously demonstrated that a conformational change is a key event leading to receptor activation.

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Activation of p38 in stimulated human neutrophils: phosphorylation of the oxidase component p47phox by p38 and ERK but not by JNK. We are reporting a case of a 22 year-old female patient, who underwent a pancreaticoduodenectomy previously for a solid-pseudopapillary neoplasm of the pancreas and was re-admitted seven years later with a pancreatic leak following disruption of the pancreatico-jejunal anastomosis. The conserved active site proline determines the reducing power of Staphylococcus aureus thioredoxin. In particular, we find that, for a wide range of frequencies, the data collapse by scaling the displacements with the inverse square of frequency, the inverse of the force amplitude, and the square of gravity. Upper airway and soft tissue structural changes induced by CPAP in normal subjects.

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The properties obtained have been used as input for multiple linear regression analysis and as descriptors for a back-propagation neural network to predict the binding affinity of alpha-chymotrypsin inhibitors. mGluR2 is enriched in the dentate gyrus and inner layer of the entorhinal cortex. Quantitative expression analysis (real-time PCR) showed up to an eightfold increase in the level of expression of the cyp51A gene compared to that by the susceptible strain. The analysis of these CCD images allows the identification of the static exposure cases and partly the angle of incidence at a dose level of 20 mSv. Type 2 deiodinase Thr92Ala polymorphism is not associated with arterial hypertension in type 2 diabetes mellitus patients. There were many causes for temporomandibular joint (TMJ) ankylosis including infection, trauma, degenerative changes and space-occupying lesion. These experiments were conducted to determine whether p185 can be therapeutically targeted in adenocarcinoma of the lung using an anti-p185-gelonin conjugate.

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The clinical data of 12 patients who were implanted with non-permanent filter for documented deep venous thromboembolism in Peking Union Medical College Hospital from September 2003 to June 2006 were retrospectively analyzed. Luliberin analogues exhibiting a cytotoxic effect on tumor cells in vitro. A gas mixture of impurities and helium after passing through a RF discharge for dissociation of molecules is directed onto the surface of superfluid helium to form the nanoclusters of impurities. Furthermore, there appear to be some contrasting opinions between the various ethical codes with respect to what would be considered unethical behavior in a non-sexual dual relationship. A network co-occurrence analysis identified two highly connected clusters as albenza online well as subclusters of putative pathogens and growth-promoting bacteria. Four brief reports of combined skin lesions are presented: (1) combined basal cell epithelioma and histiocytosis X.

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The flow cytometric dihydrorhodamine 123 (DHR) assay is used as a screening test for chronic granulomatous disease (CGD), but complete myeloperoxidase (MPO) deficiency can also lead to a strongly decreased DHR signal. Polyoxyethylene fatty acid esters as potential promotors of transdermal absorption for morphine hydrochloride and sulphate. Smooth muscle cells were absent from the venous system characteristic of the embryo at the stages examined. Optical transmission of nematic liquid crystal 5CB doped by single-walled and multi-walled carbon nanotubes. Higher preparedness was associated with higher caregiving rewards and better mental health. The primary outcome of this clinical trial was operative morbidity (any surgical or nonsurgical complications).

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The development of retinopathy in sucrose-fed and streptozotocin-diabetic rats. The adsorbed SA was detected using the technique of Fourier transform attenuated total internal reflection infrared spectroscopy (FT-ATR-IR). Mixed crystal infrared spectroscopy of uniaxially drawn polyethylene films. Brief review is provided of recent research on the impact of early visual language exposure on a variety of developmental outcomes, including literacy, cognition, and social adjustment. This reduced the likelihood of drug efflux via exocytosis from resistant tumor cells. Its evolution and mortality rate are quite different than these observed in arterial mesenteric ischemic accident. Furthermore, we propose to map the synthetic puncture force data to the puncture force data obtained on animal/human tissue to evista dosage osteoporosis create a simulation model of the procedure. We searched the Cochrane Infectious Diseases Group Specialized Register, MEDLINE, CENTRAL, EMBASE and LILACS and reference lists of articles up to 23 May 2014.

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Migraine and epilepsy share several pathophysiological mechanisms which involve neurotransmitters and iron channel dysfunctions. Many protein-protein interactions (PPIs) are mediated by protein domains. Detection of epileptiform activities in the EEG using neural network and expert system. Effects of urea on the molecules involved in the olfactory signal transduction: a preliminary study on Danio rerio. Detection of RTK pathway activation in Drosophila using anti-dpERK immunofluorescence staining. The elavil 10 mg weight gain purpose of this study was to determine the ability of noninvasive imaging methods to localize focal liver lesions to specific hepatic segments. This process produces more opportunities for economic capital growth and upward mobility than bonding social capital. Rare dominant gain-of-function mutations in PCSK9 cosegregate with hypercholesterolemia, and one mutation is associated with a particularly severe FH phenotype.

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A dynamic Thurstonian item response theory of motive expression in the picture story exercise: solving the internal consistency paradox of the PSE. Smoking habits: the prevention role of teachers and general practitioners. The presence of annual rhythms in the content serum should be considered in the interpretation of the results of immunological studies, as well as in planning and realization of different therapeutic and prophylactic measures. The in vivo IR-induced dephosphorylation of H1 is completely blocked by wortmannin and is abrogated in ataxia telangiectasia cells. Cutl1/CCAAT displacement protein (CDP) is a transcriptional repressor of mouse mammary tumor virus (MMTV), a betaretrovirus that is a paradigm for mammary-specific gene regulation. T30177 inhibited HIV-2 integrase with similar potency as HIV-1 but inhibited feline and simian immunodeficiency virus integrases at higher concentrations, suggesting selectivity can be achieved. Genetic structure of populations and zyrtec dissolve tabs ingredients conservation issues relating to an endangered catfish, Clarias batrachus, in India.

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