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Topgraf (Tacrolimus)

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Topgraf works on the immune system to prevent rejection of an organ transplant and is usually taken in combination with other anti-rejection medications. Swallow the capsules and tablets whole. Don’t cut, crush, or chew them.

Other names for this medication:
Acroli, Crolim, Cromus, Mustopic, Olmis, Pangraf, Protopic, Seegraf, Tacloran, Tacrel, Tacrim, Tacroderm, Tacrograf, Tacrokid, Tacrolimus, Tacromus, Tacrotor, Tacrovate, Tacroz, Tacstead, Talimus, Tarcel, Techlomus, Topgraf, Triplibact, Vingraf

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Also known as: Tacrolimus


Tacrolimus injection is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). This medicine may be used with steroids, azathioprine, or mycophenolate mofetil. Tacrolimus belongs to a group of medicines known as immunosuppressive agents.

When a patient receives an organ transplant, the body's white blood cells will try to get rid of (reject) the transplanted organ. Tacrolimus works by suppressing the immune system to prevent the white blood cells from trying to get rid of the transplanted organ.

Tacrolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body's ability to fight infections. You and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is to be given only by or under the direct supervision of a doctor.


Generic Topgraf can be taken in form of capsules (0.5 mg, 1 mg, 5 mg) and in injectable form. The dosage of Generic Topgraf depends on the type of your disease and health state. Take Generic Topgraf 2 times a day. Take Generic Topgraf orally, once a day with or without food. Avoid grapefruit or grapefruit juice. Avoid vaccinations. Do not stop taking Generic Topgraf suddenly.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Topgraf are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not use Generic Topgraf if you are allergic to Generic Topgraf components. Do not use Generic Topgraf while you are pregnant or have nurseling. Do not take Generic Topgraf if you use cyclosporine (such as Gengraf, Neoral, Sandimmune). Try to be careful with Generic Topgraf usage in case of taking bromocriptine (Parlodel), carbamazepine (Tegretol), cimetidine (Tagamet), cisapride (Propulsid), clarithromycin (Biaxin), clotrimazole (Mycelex, Lotrimin), danazol (Danocrine), diltiazem (Cardizem), erythromycin (E-Mycin), fluconazole (Diflucan), ganciclovir (Cytovene), HIV protease inhibitors such as indinavir (Crixivan) and ritonavir (Norvir), itraconazole (Sporanox), ketoconazole (Nizoral), methylprednisolone (Medrol), metoclopramide (Reglan), nefazodone (Serzone), nicardipine (Cardene), nifedipine (Adalat, Procardia), omeprazole (Prilosec), phenobarbital, phenytoin (Dilantin), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane), spironolactone (Aldactone), triamterene-containing drugs (Dyazide, Dyrenium, Maxzide), troleandomycin (Tao), verapamil (Calan, Isoptin), and vitamins, amiloride (Midamor, Moduretic), cyclosporine (Neoral, Sandimmune), oral contraceptives (birth control pills). Try to be careful with Generic Topgraf if you suffer from or have a history of kidney or liver disease, diabetes, high blood pressure. Avoid ill people. Avoid grapefruit or grapefruit juice. Protect your skin from the sun. Avoid vaccinations. Be careful with Generic Topgraf if you are going to have a surgery. Avoid alcohol. It can be dangerous to stop Generic Topgraf taking suddenly.

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Increasing expression of ILK occurs in the early phase of UUO mouse and may play an important role in the process of TIF through mediating the epithelial-mesenchymal transition. Characterization, quantitation and mobilization of early hematopoietic progenitors: implications for transplantation. Our study assessed nanofiber formation and their selected thermal, mechanical, and optical properties. Samples can be processed in bulk, and an individual can easily process thousands of samples for extraction and shipment on a daily basis using only common laboratory materials such as plastic ware and a multichannel pipetteman. Variation is not a consequence of differences in need, but reflects clinical practice and supply of services. In children with Charcot-Marie-Tooth (CMT), to identify the impact of muscle strength and range of movement on the static/dynamic balance and standing long jump based on quantitative and functional variables. Problems with hygienic standardization at the plenary session of the board of directors of the All-Union Scientific Society of Hygienists (ASSH). Oxidation of low density lipoprotein (LDL) has been recognized as playing an important role in the initiation and progression of atherosclerosis. Serum PEP activity was significantly higher in patients with PTSD and concurrent major depression than in patients with PTSD without major depression. Spherical equivalent refractive outcomes and their distribution by ROP zone and treatment.

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Examination of the teaching styles of nursing professional development specialists, part II: correlational study on teaching styles and use of adult learning theory. From this perspective, we review several enhanced conformational sampling techniques of biomolecules developed by us. This case provides some insight into the complex hemodynamic change exerted by the fistulous AVM and the mechanism of the development of acquired Chiari malformation type I. To review the pathophysiologic mechanisms involved in hypertrophic olivary degeneration, with attention to epidemiologic and clinical aspects and especially to imaging findings. The rates of pathological complete response were increased in locally advanced rectal cancer patients who underwent short-term induction chemotherapy. In diffuse Lewy body disease (DLBD), they decreased, accompanying linear neuritic structures. The authors also observed a negative association between age at menarche and age at menopause. Solitary nerve sheath tumors such as benign schwannomas arising in the pelvic retroperitoneum are infrequently reported. Real-time elastosonography: useful tool for refining the presurgical diagnosis in thyroid nodules with indeterminate or nondiagnostic cytology.

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The increase of lipid mobilizing activity in human obesity induced by physical training. The effect of stressors: trauma, sepsis and multiple organ failure. Effectiveness of hypnosis for the treatment of vulvar vestibulitis syndrome: a preliminary investigation. The diversity of application of the thiol drug NAC in both the experimental setting, as a tool for the study of the mechanisms and consequences of oxidative stress, and the clinical setting, as a therapeutic agent, clearly reflects the central role played by the redox chemistries of the group XVI elements, oxygen and sulfur, in biology. Surgical repair of abductor hallucis muscle herniation: a case report. By the fifth day, there was a noticeable increase in the neuronal network that gradually increased throughout the experimental period. Most stenotic sites were seen as slightly dilatated after NTG administration. To enable us to study how humans combine simultaneously present visual and proprioceptive position information, we had subjects perform a matching task. The data obtained suggest the improvement of the endothelial function and the microcirculation indices. In addition, we observe smaller influences of both protein size and protein amino acid composition in the averaged residue solvent exposures for individual proteins.

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