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Soflene (Adapalene)

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Soflene is a topical retinoid with FDA approval for the treatment of acne vulgaris. Clinicians use retinoids are used to treat a wide variety of skin disorders. Soflene also has multiple off-label therapeutic applications.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adgraze, Adiff, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Deriva, Difra, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Flomax, Lexapro, Chloromycetin, Avapro, Asacol, Mobic, Abilify, Neoral, Aldactone, Neuronti, Complatt, Lopid, Famoflam, Famtac, Erifor, Enselin, Lungfyl, Tensigal,

Also known as: Adapalene


Soflene is a third-generation topical retinoid primarily used in the treatment of acne. Soflene is a gel used for the treatment of acne (blackheads, whiteheads and pimples) of the face, chest or back. Soflene gel is a clear gel that powers deep inside your pores to control the buildup that leads to acne. It helps prevent the formation of new acne lesions, and can also help get rid of lesions already present. Soflene works under the skin surface to unclog pores and clear up pimples. Soflene is also known as Adapalene, Adapen, Adaferin. Generic name of Soflene is Adapalene.


Follow the directions for using this medicine provided by your doctor. Use Soflene exactly as directed. Soflene is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Soflene. Soflene should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Soflene. Continue using Soflene until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Soflene promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store at a room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Throw away the after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Soflene are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

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This study presents our initial experience in total laparoscopic central pancreatectomy with pancreatogastrostomy. Stroke survivors who continued to smoke were less satisfied with social roles and reported higher mean loneliness and depression scores. A continued quest for more effective treatments has spawned newer antidepressants and herbal treatments, which have contributed to explosive growth in antidepressant prescribing, increasing pharmacy costs, and wider but sometimes confusing choices for clinicians and patients. Markov chain formalism for polarized light transfer in plane-parallel atmospheres, with numerical comparison to the Monte Carlo method. Optimization of mass spectral features in MALDI-TOF MS profiling of Acinetobacter species.

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Dural plasmacytoma mimicking meningioma in a patient with multiple myeloma. Frequency of falling, frequency of going outdoors, use of cane or walker, age, sex, weight, type of accommodation, and duration of residence. Hoechst 33258 and Annexin V-FITC/PI staining assays were used to detect apoptosis, while inhibition of microtubule polymerization was assayed by fluorescence microscopy. Transcranial Doppler evaluation of microembolism immediately after direct-current cardioversion for atrial fibrillation in anticoagulated patients. Anxiety, depression, and judgments about the probability of future negative and positive events in children. Misregulation of Scm3p/HJURP causes chromosome instability in Saccharomyces cerevisiae and human cells. Serum diglucuronosyl bilirubin/monoglucuronosyl bilirubin ratio was high. By analyzing existing problems and construction strategies, this paper attempted to construct complex brain networks from a different point of view: that of clustering first and constructing the brain network second.

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Hypercalcemic effect of potassium iodide on serum calcium in domestic fowl. Many patients with multiple sclerosis (MS) are currently receiving treatment with interferon (IFN)-beta. Clinical Evaluation of Resin Composite and Resin Modified Glass Ionomer in Class III Restorations of Primary Maxillary Incisors: A Comparative In Vivo Study. The expression of Nef by the three plasmids was tested by transfections into COS-1 cells. An 81 year old man with a history of hypertension received intravenous recombinant tissue plasminogen activator (tPA) for right middle cerebral artery (MCA) infarction. This approach can be employed as a highly sensitive method of detection of inflammatory reactions and monitoring of their course in various pathological processes. Enzymatic esterification of free fatty acids in vegetable oils utilizing different immobilized lipases. Pain thresholds elevated by acupuncture failed to reverse when naloxone was given.

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Accurate imaging diagnosis and strict patient selection are the keys to a successful outcome. Our study findings suggest that budesonide may be effective in a select group of AIH patients. Decussations of the descending paraventricular pathways to the brainstem and spinal cord autonomic centers. The morphology and distribution of Merkel cells in primate gingival mucosa have been studied by correlated light and electron microscopic techniques. However, there has been no study to compare the dural sac size between axial loaded MRI and upright myelography. We investigated the protective effect of lipoic acid in CP-induced testicular toxicity. Atomistic modeling of peptides bound to a bactrim peds dose calculator chemically active surface: conformational implications. Functional analysis of rhomboid proteases during Toxoplasma invasion. Our findings documented the complexity of the neurochemical interactions that regulate both the motor functions of RPM and the blood flow through the muscle. The authors describe a case of a cutaneous sinus at the umbilical port site following spillage of gallstones during laparoscopic cholecystectomy.

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Community structure of phytoplankton in Haizhou bay and adjacent waters and its relationships with environmental factors. They also suggest that brain areas that encode pain intensity do not distinguish between internally or externally applied noxious stimuli, i.e., this adaptive biological mechanism prevents harm to the individual. There was considerable variation in the reporting criteria for the quarterly returns. Chest computed tomography showed diffuse ground glass lung opacification. Not all stereotyping is created equal: differential consequences of thoughtful versus non-thoughtful stereotyping. There was no correlation between reaction to a standard anergy panel and zantac 75 mg recall survival. Only one butanol extract produced inhibition, indicating that antimicrobial compounds are mainly lipophilic. Development of a simplified microfluidic injector for analysis of droplet content via capillary electrophoresis. Subgroup analysis for each HPS syndrome revealed a G-allele-associated beneficial effect on cancer risk occurring mainly in males.

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Endothelial differentiation gene (edg)-encoded G protein-coupled receptors (Edg Rs)-1, -3, and -5 bind sphingosine 1-phosphate (S1P), and Edg-2 and -4 bind lysophosphatidic acid (LPA). The present study aims at developing a modeling approach to estimate xenobiotic removal efficiencies from monitoring data taking the hydraulic RTD in WWTPs into consideration. Patients filled in a visual analogue scale relating to pain and post-operative nausea and vomiting for the day of operation and 7 days after operation. Investigations of cell-cell communication properties within the subpopulations of trophoblast responsible for invasion, placental growth and feto-maternal transport seem of special interest because the intercellular channels are believed to coordinate proliferation and differentiation processes. On a lactose-free elimination diet (a group of 6 on Nutramigen and a group of 10 on soy-based formula) the children caught up in growth. Static, advancing, and receding contact angles are measured with water, hexadecane, and perfluorotripentylamine in both single-fluid (droplet on solid in what drug is like bystolic an air environment) and two-fluid (droplet on solid in a liquid environment) configurations. To achieve national self-sufficiency: recent progresses in deceased donation in Korea.

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The combined anticonvulsant activity and toxicity of dilantin and N-methyl-5-phenylsuccinimide. Rectal malignant lymphoma complicating ulcerative colitis treated with long-term cyclosporine A. We analyzed outcomes and risk factors after unrelated cord blood transplantation (CBT) in adults with hematologic norvasc generic 10mg malignancies. Preventive health care and maintenance of asymptomatic chronic disease such as CKD are often neglected by patients until they become symptomatic with fluid retention and uremia. If the internal spermatic vessels found terminated intraperitoneally with a blind-end, the case was considered as a vanishing testis. They are uncommon and confirming the histopathologic classification can be challenging.

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No woman who had not had a prior pregnancy with a male fetus showed MCH. In immunofluorescence and immunohistochemichal stainings of adenoid and lymph node sections, nephrin-positive cells were detected in the germinal centres of the lymphoid follicles in a staining pattern typical for interdigitating cells. Of 183 laparoscopic major hepatectomies performed at the Institute Mutualiste Montsouris between January 1998 and March 2014, 19 patients required vascular clamping, and MPM was used in 6 patients. The anti-M1 MAbs stained the goblet cells in the epithelium intensely and there was also light and less uniform staining in the submucosa. In the first part of the study, 16 cadaveric ears were dissected. Correlation of serum and ascitic IL-12 levels with second-look laparotomy results and disease progression in advanced epithelial ovarian cancer patients. We aimed to assess low-dose recombinant human thyroid-stimulating hormone (rhTSH)-aided, fixed-activity radioiodine therapy of large, multinodular goiters (MNGs) in elderly patients with comorbidities. To assess whether Caesarean section, compared with vaginal delivery, prevents HBV transmission. The implementation of opioid switch (OS) as a strategy in non-malignant chronic pain has been scarcely proved. This article reviews two innovative programs that practiced family-centered care in assessment and program planning for children with autism spectrum disorders (ASD).

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Here we describe the isolation and characterization of another LIM homeobox gene in Drosophila termed dlim1, a homolog of the vertebrate Lim-1 gene. Continuing fingolimod after development of macular edema: A case report. HCMV upregulates B7-H1 expression in human extravillous cytotrophoblast cell line HPT-8, which is related to MAPK activation. He should be very conservative in making a diagnosis of diabetes mellitus based on this test. Acorn poisoning was diagnosed in an 11-year-old Quarter Horse with signs of severe colic, tachycardia, hyperpnea, abdominal borborygmus, rectal tenesmus, and hemorrhagic diarrhea. Numerous in-vitro and animal experiments and several clinical trials favour a once-daily dosage regimen of aminoglycosides, which provides a more rapid concentration-dependent bacterial killing and is probably less toxic than two or three dosage regimens. Our data are consistent with the hypothesis that horizontal DNA transfer has played a significant role in the evolution and size expansion of the S. Comparative proteome analysis identified 61 differentially expressed proteins, which were mainly involved in carbohydrate metabolism, amino acid transport, and metabolism, as well as energy production and conversion. DES implantation with triple-KBT was a safe and feasible technique for LM trifurcation lesion. At the last follow-up, the patient had no fever, the erythrocyte sedimentation rate and C-reactive protein level had normal values, and there was only a slight limitation in the range of motion of the cervical paraparesis.

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Treatment is initiated only when a clear clinical or radiological deterioration is documented. Polymerase chain reaction products were detected by hybridization to 96-well microtiter plates coated with either a HCMV- or an IS-specific probe. The anatomic and biomechanical complexity of the hip region often cause diagnostic uncertainty for the clinicians evaluating these injuries. Thyroglobulin B-grade used as a tracer and a reference preparation in a RIA system offered a sensitivity of 1.5 micrograms/liter for thyroglobulin detection in biological fluids. Effect of hypothyroidism on the nitrergic relaxant responses of corpus cavernosal smooth muscle in rabbits. Using a cost of pepcid complete simulation model that allows for Allee effects and a range of intrinsic dynamics, we investigated how three types of stochasticity--demographic, environmental, and random catastrophes--affect our ability to reconstruct the intrinsic dynamics of populations. Compared with MRI, MRA can be considered a useful tool for the visualization of interosseous carpal ligaments and of the triangular fibrocartilage complex. Acellular dermal matrix in the treatment and prevention of exposed vertical expandable prosthetic titanium ribs.

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Exploiting biodiversity in the marine environment: a personal perspective. Conditional loss of functional c-myc in the intestinal mucosa may have no effect on the normal homeostasis of this tissue. The discovery of a Middle to Late Triassic ( approximately 225 to 230 million years old) terrestrial vertebrate fauna from Madagascar is reported. The Lgn1 gene controlled the intracellular growth of Legionella pneumophila Philadelphia-1 and Legionella jordanis GIFU 12657, but the Bcg gene did not affect the intracellular growth of any organism examined. Our results provide some support for the utility of plyometrics as an intervention to correct altered neuromotor control in those triathletes in which it is aberrant. Our results show that IDO1 and IDO2 are not differently expressed in nonagenarians compared to controls and that the expression of IDO genes is not associated with the level of IDO activity in the plasma. Biliary cirrhosis was established by bile duct ligation in the first three groups.

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