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Sertakem (Alprazolam)

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Sertakem is a potent, short-acting benzodiazepine anxiolytic—a minor tranquilizer. It is commonly used for the treatment of anxiety disorders, especially of panic disorder. It's also used in the treatment of generalized anxiety disorder (GAD) or social anxiety disorder. It was the 12th most prescribed medicine in the United States in 2010. Sertakem, like other benzodiazepines, binds to specific sites on the GABAA receptor. It possesses anxiolytic, sedative, hypnotic, skeletal muscle relaxant, anticonvulsant, amnestic, and antidepressant properties. Sertakem is available for oral administration as compressed tablets (CT) and extended-release capsules (XR).

Other names for this medication:
Alcalm, Alflux, Alpaz, Alprax, Alprazolam, Alpron, Alprosym, Alproz, Alzac, Alzoact, Alzotime, Anlzium, Anxiflu, Anzilum, Aryalam, Balmusa, Calmtec, Censir, Depser, Depwell, Diprex, Endep, Endolam, Eurolam, Finezol, Fluwel, Maxorest, Meloprax, Prolam, Prosanti, Prozam, Prozolam, Restyl, Silam, Somnia, Stresnil, Suzilam, Tenolam, Texidep, Xylonite, Zolin, Zolorel, Zoltweet, Zorest

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Sinequan, Fosamax, Cardizem, Anafranil, Lexapro, Famvir, Siopelmin, Cypradin, Dytenzide, Azitrotek, Zostine, Axizox, Atazest, Qutipin, Sancet,

Also known as: Alprazolam


Sertakem is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). Alprazolam affects chemicals in the brain that may be unbalanced in people with anxiety. Sertakem is used to treat anxiety disorders, panic disorders, and anxiety caused by depression.

You should not use Sertakem if you have narrow-angle glaucoma, if you also take itraconazole or ketoconazole, or if you are allergic to Sertakem or similar medicines (Valium, Ativan, Tranxene, and others).

Alprazolam may be habit-forming. Misuse of habit-forming medicine can cause addiction, overdose, or death.

Do not drink alcohol while taking Sertakem. This medication can increase the effects of alcohol. Alprazolam may be habit-forming and should be used only by the person for whom it was prescribed. Keep the medication in a secure place where others cannot get to it.


This section provides information on the proper use of a number of products that contain alprazolam. It may not be specific to Sertakem. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is used for a long time, it may become habit-forming (causing mental or physical dependence) or cause an overdose.

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Swallow the extended-release tablet or tablet whole with a full glass of water. Do not break, crush, or chew it.

If you are using the orally disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not remove the tablets from the bottle until you are ready to take it. Place the tablet immediately on the top of your tongue. It should melt quickly and be swallowed with saliva.

If you are using the oral liquid, measure the dose with a marked measuring spoon, oral syringe, or medicine cup.

Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For anxiety: For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.25 to 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 4 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For panic disorder: For oral dosage form (extended-release tablets): Adults—At first, 0.5 to 1 milligram (mg) taken in the morning once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.5 mg taken in the morning once a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage forms (solution, tablets, or orally disintegrating tablets): Adults—At first, 0.5 milligram (mg) 3 times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 10 mg per day. Older adults—At first, 0.25 mg 2 or 3 times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention if you think you have used too much of this medicine. An overdose of Sertakem XR can be fatal.

Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, fainting, and coma.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details.

Side effects

The most common side effects associated with Sertakem are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of alprazolam in the elderly. However, elderly patients are more likely to have unwanted effects (eg, severe drowsiness, dizziness, confusion, clumsiness, or unsteadiness) and kidney, liver, or lung problems, which may require caution and an adjustment in the dose for patients receiving this medicine.

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This study was aimed to analyse the ethanolic extracts of Curcuma rhizome (Curcuma longa Linnaeus) and Zingiber rhizome (Zingiber officinale Roscoe) in terms of polyphenols, antioxidant activity and anti-melanoma potential employing the B164A5 murine melanoma cell line. These data define distinct pathways for the phagocytosis of corpses and bacteria in Drosophila. Pet-1 was still required in adult 5-HT neurons to preserve normal anxiety-related behaviors through direct autoregulated control of serotonergic gene expression. Endoscopic retrograde cholangiopancreatography (ERCP) is an important diagnostic and therapeutic modality for pancreatic and biliary disorders. We retrospectively reviewed a total of 1596 patients who underwent surgery for gastric cancer between January 1995 and January 2007. The patient was a 26-year-old man who complained of headache and vomiting.

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No permanent neurological deficits were incurred by either patient. High-throughput assays of phagocytosis, phagosome maturation, and bacterial invasion. Data support early intervention with ACE inhibitor therapy alone in asymptomatic cardiac failure and triple combination therapy (ACE inhibitor, diuretic, digoxin) in patients with symptomatic congestive heart failure. We think methadone, or its impaired metabolism, was the major cause for her prolonged QT interval and progression to torsade. New observations on the fragmentation properties of peptides under electron impact mass spectrometry. Often the aesthetic contour deformity in a given patient consists of both fat and skin excess problems, requiring liposuction and lifting techniques for optimal results. Based on our results and on those reported in literature, we may draw the following conclusions. Nutritional habits were evaluated with a semi-quantitative food-frequency questionnaire and use of oils in daily cooking or preparation of food was also recorded. To assess the quality of clinical care provided to NBCCEDP clients, performance data are collected by NBCCEDP grantees and compared against predetermined Centers for Disease Control and Prevention (CDC) benchmarks known as Data Quality Indicator Guides.

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Recent advances in asymmetric oxidative coupling of 2-naphthol and its derivatives. Geriatric Rehabilitation Unit (GRU) of a Veterans Administration hospital. This anti-dsDNA antibody was not identified by Crithidia Luciliae method, and the analysis using ELISA method showed that the DNA-antibody is an anti-ssDNA antibody (IgG) and that it is reactive only with ssDNA by the suppression test using purified DNA with lambda phage. The algorithm was first evaluated by a test of rigid body translation. Extensive electronic searches identified 15 papers reporting the relationship between gender and help-seeking for back pain and 11 papers for headache. Laparoscopic urological surgery: differentiating what should be done from what can be done. Construction and symbiotic competence of a luxA-deletion mutant of Vibrio fischeri. For longer SOAs, this pattern reverses and RTs to targets appearing at uncued locations become faster than RTs to targets appearing at the cued location.

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Successful bone marrow transplantation in a child with X-linked hyper-IgM syndrome. IPTG (isopropyl-beta-d-thio-galactoside) induction resulted in high expression of recombinant NKG2F protein, which was then purified and identified by anti-His western blotting and LC-MS/MS. Additionally, we quantitatively examined the ability of neurotrophin-eluting, PEGPLA hydrogels to promote neurite extension in vitro using a PC12 cell culture model. Leber hereditary optic neuropathy and multiple sclerosis: the mitochondrial connection. Delays in defibrillation occurred in one of seven cardiac arrests in the intraoperative and periprocedural arenas. The spike (S) protein is one of the best characterized proteins of SARS-CoV, which plays a key role in SARS-CoV overcoming species barrier and accomplishing interspecies transmission from animals to humans, suggesting that it may be the major target of selective pressure. miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets.

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Each foil in the various stacks is made of two layers of different thicknesses, fastened together: a hydrogen-rich (plastic) layer for neutron-to-proton conversion, and a hydrogen-free coating to selectively stop/absorb the recoil protons below a certain energy cut-off. New data from the SIGMA field at Cadarache, France, have been used to determine the appropriate scaling factor for the calculated response to thermal and intermediate energy neutrons. Managing complications of radiation therapy in head and neck cancer patients: Part VI. STAT3, a transcription factor activated by IL-6, directly activates miR-21 and miR-181b-1. nov., a novel psychrotolerant bacterium isolated from the China No. Histopathologic examination revealed hyperkeratosis of the upper follicle with an inflammatory response that resulted in follicular destruction. Eight months after establishment of the colony, three does, one buck and six 12-week-old rabbits were killed. Understanding the physiological mechanism of how the nose senses airflow can aid in diagnosing the cause behind patient symptoms, which allows physicians to provide better treatment options for patients. The role of magnesium in dormancy modulation was further investigated with bioinformatics tool based in predicted interactions.

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Trans-cyclooctene tag with improved properties for tumor pretargeting with the diels-alder reaction. Our transcriptomic analyses showed activation of glycolysis, truncated activation of the tricarboxylic acid (TCA) cycle, activation of lipid synthesis, as well as activation of glutaminolysis during the early phase of ESC differentiation. The present study examined whether sudden death in patients with hypertrophic cardiomyopathy occurred with a particular pattern of frequency throughout the day. In two patients, vessel-loops previously described as aneurysms by DSA could be identified by 3D-angiography. Health care consultants as implementors of health services research. Sonographic findings of fetal hypospadias are described, and the embryology, anatomy, and associated abnormalities are discussed.

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The former approach was found to result in estimates of the standard error that were closer to the empirical standard deviation of the sampling distribution of estimated effects. They are similar to healthy control subjects with regard to both intima-media thickness and blood flow velocity in the middle cerebral artery. Performance variation in motor imagery brain-computer interface: a brief review. Interbronchial anastomosis in complete avulsion of the right primary bronchus. milleri hybridized with high frequency to pericentric and telomeric regions of its polytene complement. Although MRI is still not of routine diagnostic utility for evaluation of pediatric neuropsychiatric disorders, patterns of typical versus atypical development have emerged that may elucidate pathologic mechanisms and suggest targets for intervention. Expression of a lung developmental cassette in the adult and developing zebrafish swimbladder.

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The relationship between the bovine heart mitochondrial adenosine triphosphatase, lipophilic compounds, and oligomycin. Patients were enrolled at 3 study sites and followed for up to 36 months with serial clinical, motor function, laboratory, and electrophysiologic outcome assessments. Performance monitoring continued as these changes were implemented (the transitional group) and for 20 months thereafter (the post-intervention group). New staging system of the fifth Joint National Committee report on the detection, evaluation, and treatment of high blood pressure (JNC-V) alters assessment of the severity and treatment of hypertension. These experiments strongly support the hypothesis that MIP-1 alpha and MCP-1 contribute to the recruitment of leukocytes during the pulmonary inflammatory response to bleomycin challenge. The recent swine-origin H1N1 pandemic illustrates the need to develop improved procedures for rapid production of influenza vaccines.

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Pathological examination of the surgical specimen revealed moderately differentiated adenocarcinoma of the prostate with right iliac lymph node metastasis. Assignments of 1H, 15N, and 13C resonances have enabled the determination of the secondary structure of the protein, which consists of two alpha-helices (residues 18-31 and 89-72) and a central four-stranded beta-sheet. Peptides containing the 20 amino bupropion wellbutrin xl 150 mg xl tablet -terminal amino acid sequence of influenza virus hemagglutinin as well as acidic derivatives showed erythrocyte lysis activity only when peptides were elongated by an amphipathic helix or by carboxyl-terminal dimerization. RNA function is based upon a large variety of structural elements which are specifically assembled in the folded molecules. Couples with chronically ill children are at risk for experiencing marital stress. Impact of bariatric surgery on the oral health of patients with morbid obesity. Surgical management of gastrointestinal stromal tumours: a single centre experience during the past 17 years. Female gender, a history of diabetes mellitus, hemodialysis, and immunosuppression therapy were predictive of a medical management without the use of surgery, although in the adjusted analysis there was no association between surgery and gender.

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RP is characterized by night blindness and progressive degeneration of the midperipheral retina, accompanied by bone spicule-like pigmentary deposits and a reduced or absent electroretinogram (ERG). Seven infant patients with anterior fontanelle scalp cysts who were managed at the Paediatric Surgical Department of Muhimbili Medical Centre, Dar-es-Salaam between January 1986 and December, 1992 were studied. We present a series of 11 patients with the diagnosis of DS or AD who developed myoclonic seizures or generalized tonic-clonic seizures. Hearing was retained postoperatively only in cases in which the nerve formed a solid bundle and could be differentiated and separated from the tumor capsule without difficulty. To investigate the effect of low molecular weight heparin (LMWH) on neointimal proliferation in cultured human saphenous vein, a model of human vein graft intimal hyperplasia. Presently, the hesitating acceptance by the human user forms one of the obstacles that needs to be overcome by convincing, well-performed studies. Occasion-setting training renders stimuli more similar: acquired equivalence between the targets of feature-positive discriminations. During the course of illness, the patient developed acute renal failure in addition to his chronic renal insufficiency, making initiation of CVVH necessary.

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The conditions for secretion of the materials depend on the activity of the phagocytes. In addition to the recognized bilateral inputs from layer 13 of the tectum, we found intense retrograde labeling of neurons within the ipsilateral nuclei subpretectalis (SP), subpretectalis-caudalis (SPcd), interstitio-pretecto-subpretectalis (IPS), posteroventralis thalami (PV), and reticularis superior thalami (RS). Our study uncovers new aspects of CDK functions, which provide direction for further investigation of these critical protein kinases. Models based on an artificial neural network (the multilayer perceptron) and binary logistic regression were compared in their ability to differentiate between disease-free subjects and those with impaired glucose tolerance or diabetes mellitus diagnosed by fasting plasma glucose. Multiple sclerosis: peripheral mononuclear cells inhibit Plasmodium falciparum growth and are activated by parasite antigens. Predictive validity was determined by examining the relationship between the factors and the number of cigarettes smoked per day (CPD). The purpose of this study has been to develop a 32P- rocaltrol drug class postlabeling assay for adducts of 1,3-butadiene and its dimer, 4-vinyl-1-cyclohexene. Spatial co-localization of aquaporin water channels (AQP4) and inwardly rectifying potassium ion channels (Kir4.1) on the endfeet regions of glial cells has been suggested as the basis of functionally interrelated mechanisms of osmoregulation in brain edema. Gastro-oesophageal reflux (GOR) is associated with a number of inflammatory ENT disorders in the adult and is correlated with recurrent croup in the child. In contrast, blood flow of the renal medulla and heart was preserved until Stage III and Stage IV, respectively.

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