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Daklinza (Daclatasvir)
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Daklinza

Daklinza is a medication used in combination with other medications to treat hepatitis C. Daklinza is only available as a brand name drug. The other medications used in combination include sofosbuvir, Daklinza, and interferon, vary depending on the virus type and whether the person has cirrhosis.

Other names for this medication:
Daclatasvir

Similar Products:
Bystolic, Lozol, Estrace, Norvasc, Furadantin, Ceftin, Duricef, Coldace, Fidna, Levoxal, Ramigamma, Loreta, Asogrel,

Also known as: Daclatasvir

Description

Daklinza (daclatasvir) is an antiviral medicine that prevents hepatitis C virus (HCV) from multiplying in your body.

Daklinza is used in combination with other medications to treat chronic hepatitis C in adults.

Daklinza treats specific genotypes of hepatitis C, and only in certain people. Use only the medications prescribed for you. Do not share your medicine with other people.

Daklinza must be given in combination with other antiviral medications and should not be used alone. It is usually given with sofosbuvir, with or without ribavirin.

Daklinza is sometimes used in people who also have HIV. Daclatasvir is not a treatment for HIV or AIDS.

Dosage

Usual Adult Dose for Chronic Hepatitis C:

60 mg orally once a day Recommended Regimen and Duration of Therapy: Genotype 1: -Without cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Compensated (Child-Pugh A) cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Decompensated (Child-Pugh B or C) cirrhosis: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks -Posttransplant: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks Genotype 3: -Without cirrhosis: Daclatasvir plus sofosbuvir for 12 weeks -Compensated (Child-Pugh A) or decompensated (Child-Pugh B or C) cirrhosis: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks -Posttransplant: Daclatasvir plus sofosbuvir plus ribavirin for 12 weeks Comments: -Dose recommendations also apply to HCV/HIV-1-coinfected patients. -Optimal duration of therapy has not been established for HCV genotype 3-infected patients with cirrhosis or for HCV genotype 1-infected patients with Child-Pugh C cirrhosis. -The manufacturer product information for sofosbuvir should be consulted regarding dosing. The manufacturer product information should be consulted regarding ribavirin dosing and dose adjustments (if applicable). Use: With sofosbuvir (with or without ribavirin), for the treatment chronic HCV genotype 1 or 3 infection

Detailed Daklinza dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Daklinza are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Using this medicine will not prevent your disease from spreading. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent hepatitis C transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.

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ET-1 increases reactive oxygen species following hypoxia and high-salt diet in the mouse glomerulus. In this study, we identified neuronal precursors that can disperse through adult mammalian brain tissue. COUNCIL on Dental Therapeutics: council announces classification of additional products. Geologic carbon storage in deep saline aquifers is considered a feasible and possible approach of mitigating the problem of increasing greenhouse gas emissions. But this is the first report of occipital pilocytic astrocytoma presenting as migraine with aura.

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Using the isotopic niche as a proxy of the trophic niche during both the breeding (blood) and inter-nesting (feather) periods, we report here empirical evidence for age-, gender-, and breeding status-dependent foraging ecology and examine its potential consequences on subsequent reproduction and survival in an extremely long-lived species, the Wandering Albatross (Diomedea exulans). To observe the clinical efficacy of acupuncture at Hegu (LI 4) on central facial nerve paralysis after ischemic stroke, and explore dose-effect relationship among different stimulation intensities of acupuncture at Hegu (LI 4) as well as its optimal treatment plan. Each process was then investigated carefully to determine whether there were any problems in defining a clear standard operating procedure. The staff of the pulmonary department scored significantly higher than the staff of the other two departments, the scores for the pulmonary department being 4.1 (1.9), 4.8 (1.5) and 5.5 (1.5), respectively. The aim of this study was to shed light on the role of dissociation and habituation as facilitators of suicidal behavior, beyond other well-established risk factors of stress, such as depression and hopelessness. Nilotinib is more potent than imatinib for treating plexiform neurofibroma in vitro and in vivo. We build upon the log-domain demons algorithm and introduce a new type of OBBTree-based regularization in the registration with a natural multiscale structure. The author describes the maldistribution of psychiatric physicians in British Columbia, speculates on the causes of that phenomenon, and summarizes the response to the problem provided by the Psychiatric Outreach Program, a project sponsored jointly by the Ministry of Health and the University of British Columbia. Although in some respects the CASP-19 exhibited good psychometric properties, the internal consistency and dimensionality of the control and autonomy domains are suspect.

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The control of the decline in C16 juvenile hormone (C16JH) synthesis in the final larval stadium of the viviparous cockroach Diploptera punctata Eschscholtz was investigated to establish how nervous and humoral signals affect the activity of the corpora allata (CA) before metamorphosis. Comparing patterns of sexual risk among adolescent and young women in a mixed-method study in Tanzania: implications for adolescent participation in HIV prevention trials. The preparation and properties of tablets containing indomethacin and polyethylene glycol 6000. Coronary artery disease, left ventricular hypertrophy and diastolic dysfunction are associated with stroke in patients affected by persistent non-valvular atrial fibrillation: a case-control study. The purpose of this study was to determine prospectively whether and to what extent computerized tomography (CT) angiography can serve as the sole imaging method for a preoperative workup in patients with ruptured intracranial aneurysms.

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Computational Analysis of Molecular Interaction Networks Underlying Change of HIV-1 Resistance to Selected Reverse Transcriptase Inhibitors. Coalescence of Lipid Emulsions in Floating and Freeze-Thawing Processes: Examination of the Coalescence Transition State Theory. By correlating the rheological properties of the dispersions to their electrospinnability, we demonstrate that molecular conformation, molecular entanglement, and shear viscosity all affect electrospinning. Current technology permits monitoring for varying clinical stage rather than the effects of immunotherapy. There is a need to expand these novel cancer immunotherapeutic modalities for cancer patients all over the world. Intragenic duplication of EHMT1 gene results in Kleefstra syndrome.

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Levels of fractional exhaled nitric oxide (FENO), spirometric values, prevalence of respiratory symptoms, and self-evaluated exposures were compared between 139 Norwegian salmon workers and 127 Russian trawler workers. Trabecular meshwork and lamina cribrosa share a common neuro-ectodermal embryological, which contribute to explain the interconnection between anterior and the posterior chamber during glaucoma pathogenesis. Total RNA was extracted from defined regions of single 50 microm sawed sections. Determination of berberine in Rhizoma coptidis and its preparations by non-aqueous capillary electrophoresis. Comparison of the Wechsler Adult Intelligence Scale and the Wechsler Adult Intelligence Scale-Revised. Regression analysis showed that individuals who endorsed supernatural explanations more strongly tended to have no exposure to psychology courses and heightened religiosity. To determine the prevalence of echocardiographic abnormalities and identify associated clinical and laboratory features in a large systemic lupus erythematosus (SLE) cohort.

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daklinza 2021-04-13

Lipid rescue for bupivacaine toxicity during cardiovascular procedures. To evaluate CT-guided radiofrequency (RF) ablation of osteoid osteoma using internally cooled monopolar RF electrodes for technical success, complications and clinical long-term success. Although the cell-cycle defects that are seen in pRb-deficient myocytes can be explained by the well-described function of pRb as a negative regulator of the transition from G1 to S phase, it remains unclear how pRb positively affects late muscle-gene expression. This study concerns parasitological investigations estimating the prevalence of intestinal parasites in the Afghan community based on the example of patients, both children and adults, treated in the Ghazni Provincial Hospital, in the eastern part of the country. Conditional logistic regression models adjusted for Helicobacter pylori infection status, BMI, smoking, physical activity, education, and energy intake were used to estimate relative cancer risks. We found that expression of BZLF1, which encodes the immediate-early gene product Zta, was expressed in SNK/T cells and the expression levels were preferentially high in cell lines from CAEBV infection. The in-vitro wound-healing test performed on fibroblasts confirmed the differences between the two vehicles. Body mass index and midarm circumference remained significant after multiple regression analysis. Cryogenically stored placental villous explants shipped frozen can serve as a useful tool for comparative functional studies of placental villous tissues. Nurse managers and management may play a pivotal role in establishing and maintaining supportive conversations.

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The epidemiology of hepatitis C virus (HCV) in HIV has changed significantly over the past decade. MicroRNA-147b regulates vascular endothelial barrier function by targeting ADAM15 expression. TomoDirect: an efficient means to deliver radiation at static angles with tomotherapy. This article identifies a range of different kinds of risks that medical apps can what over the counter medicine is equivalent to protonix contribute to and important contextual variables that can modify these risks. However, this approach has been rarely used because of its mathematical and implementation complexity. The eyes were fixed and observed under light and electron microscopy.

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Routine use of maintenance therapy in follicular lymphoma: examine the rationale for maintenance use before uniformly adopting a strategy. To quantify the risk of dementia among adults with recent TBI compared with adults with NTT. With the initial label map provided by nonrigid registration methods, its corresponding signed distance function can be estimated and used to evaluate the segmentation confidence. In this report, several problems by using endotracheal intubation (e.g. In fact, we find that GRR copy number is highly variable in natural D. Although this charging behavior is typical for an aqueous electrolyte solution, the local minimum gradually turns into a maximum as the density of the hard spheres increases. To determine whether either of two magnetic resonance imaging approaches - delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC), or T2 mapping - can detect short-term changes in knee hyaline cartilage among individuals taking a formulation of collagen hydrolysate. This 24-sample comparison resulted in a very large set of identified proteins and phosphorylation sites in pluripotent cells. This assumption is based on research from the norvasc 5 mg uses in urdu terrestrial environment and theoretical evolutionary modelling.

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Differences in quantitative assessment of myocardial scar and gray zone by LGE-CMR imaging using established gray zone protocols. An examination revealed that all her fingers, with the exception of her thumbs, had no interphalangeal fold. All the observations presented capillary thrombosis of the renal glomeruli the extent and dissemination of which had influenced the size of cortical necroses. Actual docking of different inhibitors at this site provides a structural basis to explain the dynamics of COX inhibition. All families found the services of specialized day-care units both useful and pleasant. All seizures began as complex partial seizures (CPSs), which exhibited a motionless stare with or without leftward deviation of both eyes, and evolved to secondarily generalized tonic-clonic seizures (SGTCSs) for approximately 90 s. This study offers one aetiology of the condition that results from improper kinematics during the tennis backhand stroke. A modified risk-behavior questionnaire was presented after donation via an automated telephone polling system to 805 of 15,092 Hong Kong Chinese voluntary blood donors. Analysis of humoral immunity of hepatitis D virus DNA vaccine generated in mice by using different dosage, gene gun immunization, and in vivo electroporation.

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Baseline data on urinary catheter use, catheter appropriateness, and CAUTI were collected from participating units. sinensis (CsHK), the first key regulatory enzyme of the glycolytic pathway, was characterized in this study. Low-flow vascular malformations of the head and neck: clinicopathology and image guided therapy. E.coli HB101 harboring recombinant plasmids carrying the gene(s) encoding the phaseolotoxin-insensitive enzyme activity exhibited resistance to purified phaseolotoxin. Ultrasonography revealed an anechoic mass in the superficial lobe of the parotid gland. (6) Volumetric capnography is suggested to assess CO(2) elimination and the ratio of dead-space volume to tidal volume (V(D)/V(T)) to optimize mechanical ventilation. In addition to measurement of serum and urine levels, the concentration in bronchial mucus was also examined, and their correlation was calculated. This study reports the side effects observed in the use of this drug in 12 patients.

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We introduce a numerical method to integrate the stochastic Landau-Lifshitz-Gilbert equation in spherical coordinates for generic discretization schemes. The temporal pattern of bone-level alterations in conventionally restored implants is dependent upon healing mode (open or submerged). Design and characterization of orally active Arg-Gly-Asp peptidomimetic vitronectin receptor antagonist SB 265123 for prevention of bone loss in osteoporosis. Peripheral blood and liver function in patients with liver cirrhosis after hemosorption. In this respect, many efforts have been dedicated to controlling classical swine fever (CSF) in the European Wild Boar. Degradation mechanism and control of blended eri and tasar silk nanofiber. To evaluate oesophageal acid exposure, reduction of gastric acid secretion and histology of oesophageal biopsies in infants who clinically do not respond to oral ranitidine.

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