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Crestor

Crestor is an HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke. The FDA monograph states that Crestor is indicated as an adjunct to diet in the treatment of triglyceridemia, Primary Dysbetalipoproteinemia (Type III Hyperlipoproteinemia), and Homozygous Familial Hypercholesterolemia.

Other names for this medication:
Creston, Dorosur, Liparon, Provisacor, Richstatin, Rosumed, Rosuva, Rosuvas, Rosuvast, Rosuvastatin, Rosuvastatina, Rosuvastatinum, Rosuvastin, Rovartal, Rovast, Rozavel, Simestat, Sinlip, Turbovas, Visacor, Zyrova

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Also known as: Rosuvastatin

Description

Crestor (rosuvastatin) belongs to a a group of drugs called HMG CoA reductase inhibitors, or "statins." Rosuvastatin is used together with diet to lower blood levels of "bad" cholesterol (low-density lipoprotein, or LDL), to increase levels of "good" cholesterol (high-density lipoprotein, or HDL), and to lower triglycerides (a type of fat in the blood).

Crestor is used in adults and children who are at least 8 years old to lower cholesterol and triglycerides in the blood.

Crestor is used in adults to slow the progression of atherosclerosis (a build-up of plaque in blood vessels that can block blood flow).

Crestor is used to lower the risk of stroke, heart attack, and certain other heart complications in men 50 years and older and women 60 years and older who have coronary heart disease or other risk factors.

Crestor is also used to treat hereditary forms of high cholesterol, including the heterozygous type (inherited from one parent) and the homozygous type (inherited from both parents). For the heterozygous type, Crestor can be used in children who are at least 8 years old. For the homozygous type, this medicine can be used in children as young as 7 years old.

Dosage

Usual Adult Dose for Hyperlipoproteinemia:

Initial dose: 5 mg to 10 mg once a day with or without food Maintenance dose: 5 mg to 40 mg once a day with or without food

Usual Adult Dose for Hyperlipoproteinemia Type IIa (Elevated LDL):

Initial dose: 5 mg to 10 mg once a day with or without food Maintenance dose: 5 mg to 40 mg once a day with or without food

Usual Adult Dose for Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL):

Initial dose: 5 mg to 10 mg once a day with or without food Maintenance dose: 5 mg to 40 mg once a day with or without food

Usual Adult Dose for Hyperlipoproteinemia Type IV (Elevated VLDL):

Initial dose: 5 mg to 10 mg once a day with or without food Maintenance dose: 5 mg to 40 mg once a day with or without food

Usual Adult Dose for Atherosclerosis:

Initial dose: 5 mg to 10 mg once a day with or without food Maintenance dose: 5 mg to 40 mg once a day with or without food

Usual Adult Dose for Homozygous Familial Hypercholesterolemia:

Initial dose: 20 mg once a day with or without food Maintenance dose: 20 mg to 40 mg once a day with or without food

Usual Adult Dose for Prevention of Cardiovascular Disease:

Initial dose: 5 mg to 10 mg once a day with or without food Maintenance dose: 5 mg to 40 mg once a day with or without food Response to therapy should be estimated from preapheresis LDL-C levels.

Usual Geriatric Dose for Hyperlipidemia:

Initial dose: 5 mg once a day with or without food Maintenance dose: 5 mg to 20 mg once a day with or without food

Usual Pediatric Dose for Heterozygous Familial Hypercholesterolemia:

Pediatric patients 10 to 17 years of age: Usual dose range: 5 to 20 mg orally once a day with or without food. Doses should be individualized according to the recommended goal of therapy. Adjustments should be made at intervals of 4 weeks or more. Maximum dose: 20 mg orally once a day

Detailed Crestor dosage information

Overdose

If you overdose Crestor and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Crestor are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Crestor if you are allergic to rosuvastatin, or if you have:

liver disease/high levels of liver enzymes in your blood; or if you are pregnant or breastfeeding.

Do not take Crestor if you are pregnant. Rosuvastatin could harm the unborn baby or cause birth defects. Stop taking this medicine and tell your doctor right away if you become pregnant. Use effective birth control to prevent pregnancy while you are taking this medicine.

Rosuvastatin may pass into breast milk and could harm a nursing baby. Do not breastfeed while you are taking this medicine.

To make sure Crestor is safe for you, tell your doctor if you have ever had:

liver problems; kidney disease; a thyroid disorder; a habit of drinking more than 2 alcoholic beverages per day; if you are of Asian descent; or if you are 65 or older.

Crestor can cause the breakdown of muscle tissue, which can lead to kidney failure. This happens more often in women, in older adults, or people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

People of Asian descent may absorb rosuvastatin at a higher rate than other people which may cause muscle weakness/dysfunction. Make sure your doctor knows if you are Asian. You may need a lower than normal starting dose.

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Although this review mainly focuses on HBV, the innovative applications of phage display could also be extended to other infectious diseases. Incorporating performance data in functional image analysis may be more revealing of system characteristics than simply examining mean blood flow values. We evaluated several serum markers of atherosclerosis and endothelial function in a group of essential hypertensive patients classified on the basis of their salt sensitivity. The long-term results and predictors of success for vascular access at The Toronto Hospital were studied. The aim of this study was to review our experience of ERCP in patients with Billroth II gastrectomy, and the complications associated with this procedure. Mucin (MUC5AC) expression by lung epithelial cells cultured in a microfluidic gradient device. Cortical potentials are estimated from scalp potentials using a realistically shaped inhomogeneous head model, by means of the boundary element method (BEM). There are growing fears about the rate at which AIDS is spreading across the globe today, particularly in Africa. While haptics have been studied in other fields, medical applications of haptics remain in their infancy. We present a proportional feedback mechanism that is independent of model formulation and capable of perturbing population skeletons in an evolutionary way, as opposed to requiring constant feedbacks.

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Forty two workers underwent examinations under clinical conditions. In addition, semiformal training of village women in the basics of child health would increase community involvement in health and broaden knowledge of health care issues. Depression accounts for the greatest burden of disease among all mental health problems, and is expected to become the second-highest amongst all general health problems by 2020. The results of the logistic regression analysis indicated that Medicaid recipients and the uninsured were more likely than their commercially-insured counterparts to be admitted, without a physician referral, to an acute-care hospital in Oklahoma following an evaluation in the ED. In addition, the glutathionylation of two putative targets, namely, peroxiredoxin (Sll1621) involved in oxidative stress tolerance and 3-phosphoglycerate dehydrogenase (Sll1908) acting on amino acids metabolism, was confirmed by biochemical studies on the purified recombinant proteins. At sites of focal macrophage-erythrocyte contact we observed a distinctive specialization of the macrophage plasma membrane consisting of a prominent subplasmalemmal band of electron-dense material, approximately 25-35 nm in thickness. In human coronary arteries, neointimal coverage of an implanted Palmaz-Schatz stent may take as long as 6 months or more.

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The causative agent, the hepatitis E virus, sulfasalazine dr dose is involved in epidemic, sporadic, and fulminant hepatitis cases worldwide. FEV6 as a surrogate for FVC in detecting airways obstruction and restriction in the workplace. Inguinal hernia repair has been a common procedure performed by general surgeons. This meta-analysis supports CTA as an acceptable modality for postoperative detection of RA, although DSA remains the gold standard. Spermatozoal RNA profiling towards a clinical evaluation of sperm quality. Flat tip proponents theorize an equally effective CIN treatment with lower incidence of posttreatment squamocolumnar junction location in the cervical canal. Designing a culturally based intervention to reduce HIV sexual risk for Latino adolescents.

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The methods of restoring the partial and the complete loss of one or more anterior teeth. Visceral Leishmaniasis with an Unusual Presentation in an HIV Positive Patient. Also, the mid lumbar muscles are comparatively more activated than low lumbar muscles when the walking slope increases. The interhemispheric auditory pathway has been shown to play a crucial role in the processing of acoustic stimuli, and alterations of structural and functional connectivity between bilateral auditory areas are likely relevant to the pathogenesis of auditory verbal hallucinations (AVHs). It is concluded that the reduction of imidazolmetmyoglobin or 1-methylimidazolmetmyoglobin is faster than that of aquametmyoglobin and that neither azidometmyoglobin nor cyanometmyoglobin can be reduced by ascorbate under the present experimental conditions.

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