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Clonatrac (Clonazepam)
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Clonatrac

Clonatrac is a medication used to prevent and treat seizures, panic disorder, and for the movement disorder known as akathisia. It is a tranquilizer of the benzodiazepine class. It is taken by mouth. It begins having an effect within an hour and lasts between six and 12 hours. Clonatrac was initially patented in 1964 and went on sale in the United States in 1975. It is available as a generic medication.

Other names for this medication:
Adnil, Azpax, Catier, Clonapik, Clonasig, Clonatrac, Clonazepam, Clopam, Closis, Clotweet, Cloze, Clozipam, Convaclon, Cozil, Ection, Epcon, Epitril, Escitacalm, Escitapax, Nexclo, Norep, Ozepam, Prasilex, Ubitpam, Zepamax, Zolpidox

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Glyburide, Ilosone, Leukeran, Mircette, Strattera, Rocaltrol, Cymbalta, Rebetol, Nimotop, Sulotrim, Levofloxacina, Paracold, Xeroworm, Ecsom, Tranase, Nifediac,

Also known as: Clonazepam

Description

Clonatrac results in a depression of the activities of the central nervous system. This depression is not meant to designate a feeling of depressed mood, although some people may experience depressed mood as a side effect of Clonatrac use. It instead relates to a reduction in the rate of activity of the cells in the brain. This reduction in the rate of brain activity affects several cognitive functions, most notably the ability to form new memories. Memories are formed in the brain as a result of increased activity of neurons, and a person using a benzodiazepine like Clonatrac will experience a dampening of these processes that can interfere with the ability to form new memories while one is taking the drug.

There is some evidence that cognitive abilities, such as memory, attention, visual spatial skills, and even intellect, might be affected as a result of long-term benzodiazepine abuse; however, the research in this area is limited due to many of the subjects in the studies having a history of abusing benzodiazepines and other substances, such as alcohol.

Dosage

This section provides information on the proper use of a number of products that contain clonazepam. It may not be specific to Clonatrac Wafers. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence).

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Swallow the tablet whole with water.

If you are using the disintegrating tablet (wafer), make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil. Do not push the tablet through the foil. Do not break or split the tablet. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, you may take a sip of water.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage forms (tablets or disintegrating tablets): For seizures: Adults and children 10 years and older—At first, 0.5 milligram (mg) 3 times per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 20 mg per day. Children up to 10 years or 30 kilograms (kg) of body weight—Dose is based on body weight and must be determined by your doctor. The dose is usually 0.01 to 0.03 mg per kg of body weight per day, given in 2 or 3 divided doses. However, the dose is usually not more than 0.05 mg per kg of body weight. Your doctor may adjust your dose as needed. For panic disorder: Adults—At first, 0.25 milligram (mg) 2 times per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 4 mg per day. Children—Use and dose must be determined by your doctor.

Overdose

Benzodiazepines like Clonatrac became popular prescription medications, as alternatives to another class of anti-anxiety medications called barbiturates. Barbiturates were once very popular in the treatment of anxiety; however, they were highly addictive, carried a high risk for overdose, and were frequently abused. Benzodiazepines also carry a significant risk for the development of physical dependence and abuse (see below); however, they do not appear to carry the same risk of overdose that is associated with barbiturates (although overdose on benzodiazepines can occur).

Many of the cases of overdose that include benzodiazepines also include the co-occurring use of other drugs, such as alcohol, narcotic pain medications, or antidepressants. Using these drugs and benzodiazepines like Clonatrac together enhances the effects of all drugs as well as increases the risk for overdose and potential fatalities due to drug interactions and drug overdose.

Storage

Store at 25 degrees C (77 degrees F); excursions permitted to 15 to 30 degrees C (59 to 86 degrees F).

Side effects

The most common side effects associated with Clonatrac are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

For children, the long-term effects on physical and mental/behavioral development are uncertain and may not be seen until after many years. Therefore, discuss the risks and benefits of treatment with Clonatrac with your doctor.

Older adults may be more sensitive to the effects of this drug, especially drowsiness and confusion. These side effects can increase the risk of falling.

During pregnancy, this medication should be used only when clearly needed. It may harm an unborn baby. However, since untreated seizures are a serious condition that can harm both a pregnant woman and her unborn baby, do not stop taking this medication unless directed by your doctor. If you are planning pregnancy, become pregnant, or think you may be pregnant, immediately talk to your doctor about the benefits and risks of using this medication during pregnancy.

This drug passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

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Thus, a critical motif responsible for gating Kir2.3 by protons is 100 mg of prometrium a high dose was identified in the N terminus, which contained about 10 residues centered by Thr53. The analysis of T cell supernatants showed the specific secretion of both interleukin-2 and interferon-gamma by activated T cells. In contrast, the kinetics distributions of GABAergic and glutamatergic synaptic events received by a given interneuron do not depend upon its somatic location or dendritic arborization. To overcome this problem, a method for soil DNA extraction was proposed to the International Organization for Standardization (ISO) in 2006. Downregulation of E-cadherin by Six2 was necessary for its ability to increase soft agar growth and in vivo metastasis in an immunocompetent mouse model of breast cancer. Sprague-Dawley rats were subjected to a TBI using a weight-drop model and then killed at various time points after injury.

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The absence of appropriate care also increases the cost to the health services. Kinematic and kinetic analysis of maximal velocity deadlifts performed with and without the inclusion of chain resistance. HADO encodes a putative magnesium phosphatase with distinctive cortical localization along the concave ookinete periphery. Molecular structure and spectroscopic studies on novel complexes of coumarin-3-carboxylic acid with Ni(II), Co(II), Zn(II) and Mn(II) ions based on density functional theory. State staffing standards may not be effective policy tools because they are only one of many factors that affect facility staffing levels.

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