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Bonestat (Calcitriol)

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Bonestat is an active metabolite of vitamin D that is used to treat hyperparathyroidism and is also used in dialysis patients to combat hypocalcemia. Bonestat is a biologically active calcitrophic hormone with anti-osteoporotic, immunomodulatory, anticarcinogenic, antipsoriatic, antioxidant, and mood-modulatory activities.

Other names for this medication:
Admax, Alfacal, Alfacalcirol, Arachitol, Biocal, Calbec, Calbory, Calbovic, Calcikind, Calcimet, Calcit, Calcor, Caldix, Calosto, Calotec, Calsure, Caltive, Carcal, Cholical, Citroj, Denscal, Fovit, Koncal, Laretol, Lctrol, Ostonex, Ostriol, Refirm, Riecal, Romical, Solbiocal, Vezocal, Zaxial

Similar Products:
Lanoxin, Provera, Avapro, Xeloda, Suprax, Priligy, Floxinol, Diazero, Mahagesic, Allynol, Ibuprom, Zeemine,

Also known as: Calcitriol


Generic Bonestat is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Bonestat are intestine and bone. Generic Bonestat receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Bonestat may also act on the kidney and the parathyroid glands. Generic Bonestat is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Bonestat has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Bonestat, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Bonestat in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Bonestat produces other independent beneficial effects. Bonestat is also known as Calcitriol. Generic Bonestat treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Bonestat is Calcitriol. Brand name of Generic Bonestat is Bonestat.


Generic Bonestat is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Bonestat suddenly.


If you overdose Generic Bonestat and you don't feel good you should visit your doctor or health care provider immediately.


Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Bonestat are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


It is especially important that you receive the right amounts of vitamins so that your baby will also get the vitamins needed to grow properly. Infants who are totally breast-fed and have little exposure to the sun may require vitamin D supplementation. However, taking large amounts of a dietary supplement while breast-feeding may be harmful to the mother and/or baby and should be avoided.

Only small amounts of alfacalcidol, calcifediol, calcitriol, or dihydrotachysterol pass into breast milk and these amounts have not been reported to cause problems in nursing babies.

It is not known whether doxercalciferol or paricalcitol passes into breast milk. Be sure you have discussed the risks and benefits of the supplement with your doctor.

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A unifying explanation for agreement in both production and comprehension will be adopted in line with retrieval of an agreement source from a content-addressable memory sensitive to structural positions and their implementation in different languages. Locomotor activity and speed of movements in relation to monoamine-acting drugs. During language comprehension, listeners use the global semantic representation from previous sentence or discourse context to immediately integrate the meaning of each upcoming word into the unfolding message-level representation. Officers with additional experience in kickboxing or karate/jiu-jitsu (training several times per week), or krav maga (training once a week) and officers with no additional experience performed several arrest and self-defence skills under low and high anxiety. The aim of this study was to assess the validity of body fatness estimations based on skinfolds and bioelectrical iImpedance analyses (BIA) measurements compared to a three-component model (3C model) in prepubertal Chilean children, considering potential differences by sex and nutritional status. We report epidemiologic, clinic, para clinic, therapeutic and evolution aspects of septic arthritis in African tropical zone. Early in vivo studies showed that the uptake of external methionine is repressed by the level of the internal methionine pool, a phenomenon termed transinhibition. Assessment of ventricular volumes using cine magnetic resonance in the intact dog. Because of its large size, easy accessibility, and well-characterized genetics, the fly NMJ remains an excellent model system for dissecting the cellular and molecular mechanisms of synaptic transmission.

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Nerve conduction studies were performed in the distal sural and ulnar sensory nerves and the peroneal motor nerve in 456 individuals with type 1 diabetes who participated in the follow-up visit of the EURODIAB Prospective Complications Study (EPCS). The tools can be valuable for assessing NP practice regarding spiritual care within relationship-based and patient centered care. Potential differences between the methods and sites that may contribute to this effect are discussed. The results show that the theoretical standard electrode potential of half reaction for p-Q and p-AP is 0.682V at B3LYP/6-31G(d,p) level and 0.622V at HF/6-31G(d,p) level, respectively, indicating that computed standard electrode potential at B3LYP/6-31G(d,p) level are more reliable than that at HF/6-31G(d,p) level. The effect of CYP1A2 gene polymorphisms on Theophylline metabolism and chronic obstructive pulmonary disease in Turkish patients. To analyse the association between income and health-related quality of life using the Medical Outcome Study Short Form 36 (SF-36) Chinese version in Hong Kong Chinese working population. Sixty-two patients with well-controlled type 2 diabetes and an age, gender and body mass index-matched group of 58 healthy individuals were recruited. Despite low peri-operative mortality after major lower extremity amputation, long-term mortality remains substantial. The methods used, their suitability for nanotoxicity testing, and the technical problems encountered are carefully described and discussed in this paper. We also examine associations between sexual agreements and HIV testing and perceived risk among partnered MSM.

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Since significant differences in polyploidization exist between the control regions of hearts of similar weight primarily regions of the same heart are compared. Improving maternal and newborn health: effectiveness of a community health worker program in rural Kenya. When in spite of conservative treatment signs and symptoms persist, urinary by-pass with antibiotic prophylaxis must be performed. An unlikely CDR-score in combination with a normal D-dimer excluded pulmonary embolism. In selected adolescent patients with osteosarcoma, in whom the tumour is in full contact with the epiphysis, epiphyseal preservation by epiphysiolysis and reconstruction by distraction osteogenesis can provide an excellent outcome, resulting in a stable reconstruction that functionally restores the native limb. In NIDDM also the carbohydrate metabolism can improve significantly. The rate of ventricular enlargement seems to be even more strongly predictive of disease progression after medium term follow-up than whole brain atrophy rate, and also outperforms lesion measures. It was found that education could have positive effects on pregnancy, childbirth, breastfeeding, motherhood and infant care, and that it could at the same time have a positive or negative effect on fear of childbirth. Effects of A2BR on the biological behavior of mouse renal fibroblasts during hypoxia. These lipids block IL-2 and IFN-gamma can you take flagyl antibiotic gene transcription without inhibiting the production of IL-4 and IL-10 mRNA.

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Families of solitons in one- and two-dimensional (1D and 2D) Gross-Pitaevskii equations with the repulsive nonlinearity and a potential of the quasicrystallic type are constructed (in the 2D case, the potential corresponds to a fivefold optical lattice). Furthermore, these conclusions have been corroborated by the observation that chondrocyte-specific overexpression of PTHrP causes a profound delay in the developmental program of chondrocyte differentiation and endochondral ossification (Weir et al., 1995). Though the notion of phase synchronization has been well studied in chaotic dynamical systems without delay, it has not been realized yet in chaotic roxithromycin pbs cost time-delay systems exhibiting non-phase-coherent hyperchaotic attractors. We also identified three proteins that are members of a novel family of autotransporters, multiple potential type I protein secretion systems, and proteins that appear to be components of a type VI secretion apparatus. To compare composite subtraction ictal single-photon emission computed tomography coregistered to magnetic resonance imaging (also known as SISCOM) patterns between right and left medial temporal-onset seizures to document neuroanatomical involvement in perfusion patterns. Particulate contamination of spray-dried and lyophilized injectable carbenicillin. The quantitative evaluation of Disc Electropherograms was effected by means of microdensitometric analysis with integration. We applied Tuija Leinonene and Helena Leino-kilpi scales as the theoretical framework, and established perioperative nursing quality assessment scale by translation, language study, and expert consultation.

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Forty consecutive patients with median age of 11.9 years (range, 1.5-16 years) who received HSCT for acute leukemia and had comprehensive echocardiography before and after (median 9.2 month) HSCT were included in this study. A retrospective chart review was conducted of the 20 patients treated at the local tertiary care centre over the 5-year period. The fluorescent lipids were incubated with homogenates of stimulated bovine alveolar macrophages. Our previous studies on surface antigenic properties of murine small thymocyte subpopulations raised the hypothesis that some of the least dense cells, which possibly were precursor T cells, differentiated into the most dense cells which have the properties of mature T cells. Effects of chronic exercise on renal function in 5/6 nephrectomized spontaneously hypertensive rats (SHR).

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Concomitant fungal and bacterial atlanto-axial osteomyelitis: a case report. An oligonucleotide primer pair was designed to amplify a 420-bp DNA fragment from E. Our results suggest that in hepatic cells, hexanoate needs to be activated into a CoA derivative in order to inhibit the insulin and T(3)-induced FAS expression. Predictors of HVTN 503 MRK amoxil 400 mg 5 ml dosis -AD5 HIV-1 gag/pol/nef vaccine induced immune responses. Anterior neural development requires Del1, a matrix-associated protein that attenuates canonical Wnt signaling via the Ror2 pathway. Insulin-like growth factor-1 (IGF-1) and IGF-2 are critical regulators of cell proliferation. Electron capture induced dissociation of dipeptide dications: where does the charge go?.

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The sensitivity of the TWEAK can be increased if the cut point for the first tolerance question is set at two drinks, with some loss of specificity and predictive ability. Mucopolysaccharidosis type IVA (MPS IVA), also known as Morquio A syndrome, is an inherited, lysosomal storage disorder caused by genetic mutations in N-acetylgalactosamine-6-sulfatase (GALNS) enzyme gene. The predictive chameleon: evidence for anticipated social action. For a given dose level, the predicted AZ for IRIS consistently outperformed that of FBP. Antimicrobial activity of 18 ethnomedicinal plant extracts were evaluated against nine bacterial strains (Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa, Ervinia sp, Proteus vulgaris) and one fungal strain (Candida albicans). A survey of stress ulcer prophylaxis in Intensive Care Units in the UK.

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There appears to be an analogous process in which mosquitoes avoid certain potential human hosts, thereby raising prospects for the development of novel, rationally identified repellents once the semiochemical/olfactory interactions have been fully elucidated. Glial-derived S100b protein selectively inhibits recombinant beta protein kinase C (PKC) phosphorylation of neuron-specific protein F1/GAP43. This chemoprotective effect was dependent on physical contact and gap junctional communication between astrocytes and tumor cells. Recent studies have found that pulmonary function returns to preoperative levels 12-24 months following endoscopic anterior scoliosis correction, and a small improvement in forced expiratory volume (FEV1) has also been reported. Several growth factors which play a role in gliogenesis were used to evaluate the mechanism(s) of proliferation and/or differentiation can you drink alcohol while taking prograf of HITS glioma. Late phase II study of KW-2307 in advanced or recurrent breast cancer. Mycoplasma hominis mediastinitis after acute aortic dissection repair.

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Maternal and paternal Asian ethnicity have differential effects on infant fat distribution. A dileucine-based protein sorting motif has recently been identified within the C-terminal, solvent-exposed loop of HIV-1 Nef and has been shown to be required for Nef-mediated down-regulation of CD4 and for optimal viral infectivity. The interaction of actin with myosin was studied in the presence of ATP at low ionic strength by means of measurements of the actin-activated ATPase activity of myosin and superprecipitation of actomyosin. one-year cross-sectional follow-up to a 12-week clinical trial of sertraline. Disruptions to circadian clocks have been linked to various diseases. Proteome analysis of Myxococcus xanthus by off-line two-dimensional chromatographic separation using monolithic poly-(styrene-divinylbenzene) columns combined with ion-trap tandem mass spectrometry. Elder-friendly designs, technology support, and physical safety using mHealth technology may be useful in noroxin drug this population. Two of them belong to the family of G protein-coupled receptors, whereas the third one is an entirely new type of neuropeptide receptor and is identical to gp95/sortilin, a 100 kDa-protein with a single transmembrane domain.

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The copper content in rations of schoolchildren and students was considerably lower the norm in summer and especially in winter. In this study, we evaluated the utility of human copper transporter 1 (hCTR1) gene as a new reporter gene for (64)Cu PET imaging. Recent advances in the understanding of the pathophysiology, aggressive treatment, and early detection of rheumatoid arthritis (RA) have changed the clinical, pathologic, and functional outcomes in patients with RA. Little is known of the mechanism of injuries confined to the articular cartilage of the trochlea of the femur. Unexpected occurrence of volatile dimethylsiloxanes in Antarctic soils, vegetation, phytoplankton, and krill.

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