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Biproate (Divalproex)

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Biproate is used to treat seizure disorders, certain psychiatric conditions (manic phase of bipolar disorder), and to prevent migraine headaches. It works by restoring the balance of certain natural substances (neurotransmitters) in the brain.

Other names for this medication:
Biproate, Desval, Devot, Dilex, Divalex, Divalin, Divalprid, Divalpro, Divalproex, Dixval, Elival, Epilex, Epival, Jydival, Kayval, Navalin, Sezex, Sodaval, Spikalon, Torvate, Trival, Valance, Valcontin, Valcot, Valfox, Valimep, Valop, Valowin, Valporiv, Valporl, Valpret, Valprid, Valprosh, Valrate, Valric, Valtec, Valver, Velpo, Velze, Zorat

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Also known as: Divalproex


Valproic acid is used to treat certain types of seizures (epilepsy). This medicine is an anticonvulsant that works in the brain tissue to stop seizures.

Valproic acid is also used to treat the manic phase of bipolar disorder (manic-depressive illness), and helps prevent migraine headaches.

This medicine is available only with your doctor's prescription.


Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Drink plenty of water while you are taking this medication. Your dose may need to be changed if you do not get enough fluids each day.

Swallow the capsule or tablet whole and do not crush, chew, break, or open it.

If you cannot swallow a sprinkle capsule whole, open it and sprinkle the medicine into a spoonful of pudding or applesauce. Swallow the mixture right away. Do not save it for later use.

You may need frequent blood tests.

If you need surgery, tell the surgeon ahead of time that you are using Biproate ER.

In case of emergency, wear or carry medical identification to let others know you use Biproate ER.

Do not stop using Biproate ER suddenly, even if you feel fine. Stopping suddenly may cause a serious, life-threatening type of seizure. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture and heat.

Detailed Biproate ER dosage information


If you overdose Biproate and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Biproate overdosage: shallow, breathing, weak pulse, sleepiness, feeling drowsy, loss of consciousness.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Biproate are:

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Combined analysis of allelic variation of the virulence-associated, strain-specific lys-gingipain gene (kgp) and major fimbrial gene (fimA glucotrol 5 mg ) of Porphyromonas gingivalis was undertaken in 116 subgingival plaque samples to understand the kgp biotype and fimA genotype profile in a subject-specific manner. Intravenous contrast medium bolus injection in computer tomography with the TuR DZ11 high-pressure injector. The definition of substance dependence has changed over time in both the DSM and ICD. We reviewed the medical records of 171 patients who were presented with synchronous metastatic renal cell carcinoma and who had received no systemic therapy before enrollment. Hepatic expression of PPARs and SREBP-1 was assessed by real time reverse transcriptase-polymerase chain reaction.

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The use of protesic polypropylene multifilament macropore mesh in the concomitant correction of cistocele and rectocele, by transvaginal route with tension free technique seems to be a safe and effective surgery procedure. The study of muscle-tendon unit under high-speed stretch could help us to understand the mechanism of strain injuries over passive stretch in real-life situations. The intersection of lineage-determining and stimulus-activated transcription factors at enhancers explains cell type specificity in inflammatory responses. to explore the feelings, perceptions and experiences of women in relation to their perineum following childbirth in the early postnatal period. Six patients have died and two are alive with good function at the time of this report. Among them, bisynchronous epileptogenic activities were found in 9 pediatric patients. Deprivation score was assessed according to small residential areas and subjects were equally distributed between four general practices in Plymouth, UK. Consistently, in vitro data showed that O-1602 increased the levels of intracellular calcium and lipid accumulation in adipocytes. Sixtythree cases were identified using a postal questionnaire (response rate 87 per cent) and, where possible (69 per cent), histories were confirmed by interview. Output of endogenous monoamine oxidase inhibitor in rats: effect of ethanol, tryptamine and tryptophan.

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