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Baclofen

Baclofen is not FDA-approved for back pain, but providers will often prescribe it for this as well as other types of pain. This is considered an "off-label" use of Baclofen. It might work for you if your back pain is caused by muscle spasms. If your pain is dull and achey or feels like pins and needles, it might not help much.

Other names for this medication:
Bacfen, Baclof, Baclofen, Bacmax, Chinofen, Liofen, Parafon, Riclofen, Spinofen, Spinospas, Tefsole

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Description

Baclofen is used to help relax certain muscles in your body. It relieves the spasms, cramping, and tightness of muscles caused by medical problems, such as multiple sclerosis or certain injuries to the spine. Baclofen does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition.

Baclofen acts on the central nervous system (CNS) to produce its muscle relaxant effects. Its actions on the CNS may also cause some of the medicine's side effects. Baclofen may also be used to relieve other conditions as determined by your doctor.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain baclofen. It may not be specific to Baclofen. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, or do not take it longer than your doctor ordered.

Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For muscle relaxation: For oral dosage form (solution): Adults and children 12 years of age and older—At first, 5 milliliters (mL) three times a day for 3 days. Your doctor may increase your dose by 5 mL every 3 days as needed and tolerated. However, the dose is usually not more than 80 milligrams (mg) per day (20 mg four times a day). Children younger than 12 years of age—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults and teenagers—At first, 5 milligrams (mg) three times a day. Your doctor may increase your dose by 5 mg every 3 days until the desired response is reached. However, the dose is not more than 80 mg per day. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Baclofen and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the oral liquid in the refrigerator. Do not freeze.

Detailed Baclofen dosage information

Side effects

The most common side effects associated with Baclofen are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of baclofen oral liquid in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems, which may require caution for patients receiving baclofen oral liquid.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of baclofen tablet in the elderly. Side effects such as hallucinations, confusion or mental depression, other mood or mental changes, and severe drowsiness may be especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of baclofen tablet.

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Memory scanning of described images and undescribed images: hemispheric differences. The aim of this study was to assess if an aggressive pharmacological preventive treatment may reduce the myocardial ischemic burden and then improve the cardiovascular outcome In ESRD patients. Two authors independently extracted data and assessed trial quality using the Jadad 5-point scale. We studied how socioeconomic status, type of settlement, allergic background of the family and skin symptoms indicative for allergy were related to primary allergy prevention in infant feeding. The metabolism of amino acids in different types of experimental diabetes. Three studies were done on patients without depression at inclusion, two studies in patients with depression and five studies included a mixture.

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The structure of interfacial water on gold electrodes studied by x-ray absorption spectroscopy. The beta3-adrenergic receptor is involved in regulation of microvascular blood flow. Patients were evaluated in terms of age, gender, type of surgery, type and diameter of the needle used for dural puncture, number(s) of dural puncture, onset of punctural headache, any conservative therapies for PDPH, number(s) of EBP application, analgesia quality at the 10th minute and 2nd hour after EBP application, and radicular pain during procedure. SEM observation showed significant differences of the hybrid layer thickness. The recording of co-morbidities and the effect of data accuracy on mortality analyses and risk adjustment were quantified. The qualitative and quantitative anatomy of the syndesmotic ligaments was reproducibly described and defined with respect to surgically identifiable bony prominences. Osteoporosis is a major health problem that will grow in burden with ageing of the global population. When the young adult has an intellectual impairment in addition to a complex chronic neurological condition, parental involvement is critical in the transition process, as these young adults are unable to make informed decisions independently and require significant guidance from caregivers. No evidence for temperature-induced change in injection barrier or interface trapping can be found to explain this phenomenon.

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Therefore, formation of an amorphous phase alone is not sufficient to maintain protein structure during dehydration. About a third of people with depressive disorder died within a year of illness onset. The activity log comprised a detailed classification of care coordination functions based on two major categories - direct and indirect care. A total of 33,425 participants in Wave 1 and Wave 2 surveys of the National Epidemiologic Survey on Alcohol and Related Condition (NESARC) were included in this study. A reference basis for future genetic studies of oil metabolism in Chlamydomonas is provided.

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Prophylactic antimicrobial management of compound depressed skull fracture. Activity in the STN of intact rats increased dramatically after amphetamine, 5 mg/kg. Development of a multiplex real-time RT-PCR assay for simultaneous detection of dengue and chikungunya viruses. Antimicrobial drug-resistant bacteria isolated from Syrian war-injured patients, August 2011-March 2013. Bilateral laminotomy and discectomy for segmental lumbar disc disease. Silver ions have been shown to combine good biocompatibility with a low risk of inducing bacterial resistance. Akt2 kinase suppresses glyceraldehyde-3-phosphate dehydrogenase (GAPDH)-mediated apoptosis in ovarian cancer cells via phosphorylating GAPDH at threonine 237 and decreasing its nuclear translocation. MicroRNA-21 is an important downstream component of BMP signalling in epidermal keratinocytes. Here, we present a detailed analysis of the homozygosity regions in a cohort of 612 patients with intellectual disabilities of different degrees.

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In this chapter we describe how to express and purify tF and induce its assembly around AuNPs. coli, they formed a stable complex and protected each other from proteolytic degradation, indicating that these two proteins interact in vivo and that no other Eps protein is required for their association. Interplay between the gastric bacterial microbiota and Candida albicans during postantibiotic recolonization and gastritis. To examine the effects of exhaustion of five different processing solutions on the sensitometric properties of four dental X-ray films: Ektaspeed Plus and Ultra-speed (Kodak Eastman Co. The objectives of this study were to: determine the presentation to publication conversion rate (PPCR) in peer-reviewed indexed journals of free papers and posters presented at 12-14th September 2001 British Orthopaedic Association (BOA) annual meeting and to compare the publication rate with the American Academy of Orthopaedic Surgeons (AAOS) meeting in 2001. Conceptual approach to the development of the 2d stage of the Gorzdrav Automated System of Management. The objective of this study was to report the short-term results and complications of unilateral scleral fixated posterior chamber IOLs in the pediatric population. Controlling methanogenesis and improving power production of microbial fuel cell by lauric acid dosing. Role of prolactin feedback in the semicircadian rhythm of tuberoinfundibular dopaminergic neuronal activity during early pregnancy in the rat.

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A precise estimate of the enzyme coverages is obtained after comparing the enzyme kinetics of the immobilized and the homogeneous system. The clinical significance of plasma ammonia measurements in the diagnosis of generalized convulsions is investigated in this study. Pretreatment with diltiazem inhibited the AGEP-induced elevation of cytosolic free calcium. In conclusion, under the conditions of these experiments, vaccination of mice and cattle with rOmpA and rSSA-1 stimulated high antibody responses and may have protective vaccine potential. Guidelines for transition should address policy and practices for pediatricians and colleges to enhance comanagement of affected youth. A study in a larger FH group or in non-FH hypercholesterolaemic subjects may further define the role of this regulatory mechanism in determining plasma lipid concentration. We analyzed the gene expression levels of study groups with Quantitative RT-PCR as well as relative gene expression.

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Tubular handling of salt and water may not provide adequate criteria to evaluate the cause of reduced glomerular filtration rate. Bradykinesia akinesia inco-ordination test (BRAIN TEST): an objective computerised assessment of upper limb motor function. X-Ray Photoelectron Spectroscopy (XPS) was used to analyze the surface chemical composition. In the latter case, much higher activity of Pd overlayers was observed. The aim of this study was to assess whether it can also improve the automatic calculation of left ventricular ejection fraction (LVEF) by QGS software package, during the stress phase of Gated SPECT. The properties of the penis retractor muscle of Aplysia have been studied using intracellular, sucrose gap and tension recording. Coping with terrorism: the impact of increased salience of terrorism on mood and self-efficacy of intrinsically religious and nonreligious people.

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The aim of this study was to investigate brain morphometry and its relation to IQ level in BIF children. lower than several tens of microSv at maximum without wearing protective clothing. In prosthodontic treatment, the loaded impression tray is the largest item requiring intraoral placement. This happened regardless of whether the cohort was divided by glucose tolerance level or by level of insulin sensitivity. Sect affiliation, conformity instinct, limits of anti-authoritarian rearing. Study on substance P immunoreactivity after acute crush injury to facial nerve. All patients were treated by cannulated screws and Kirschner wires through 1 to 2 microtubule straight incision on dorsum of foot. Effects on depressed activity of sinoatrial and atrioventricular node. Health care providers from five emergency departments completed a questionnaire assessing knowledge of blood pressure criteria for hypertension, perceived causes of elevated blood pressures, barriers to re-assessment, and perceived risk of an adverse event at one year in a patient within three defined systolic and diastolic blood pressure ranges. The hypothesis that impulsivity would directly predict heightened food consumption was not supported for either gender.

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In individual cases, promising results in patients with primary pulmonary hypertension have been reported during long-term therapy with nifedipine provided that a favorable initial response could be documented. It is conceivable that utilization of priorly available pathway knowledge would greatly facilitate both interpretation and estimation in statistical analysis of such high-dimensional biological data. During the social antecedent condition, the teacher presented opportunities for the children to greet, name objects, and request materials. The resulting estimators are highly efficient, and are significantly simpler to implement and use than alternative methods, as they contain no adjustable parameters. Four days later, lymphocyte proliferation, activity of macrophage phagocytosis, delayed type hypersensitivity (DTH), concentration of malondialdehyde (MDA), total-superoxide dismutase (SOD) enzyme activity, and cytokine expression in serum from the mice were tested. Thus, the older depressed patient is too often not diagnosed and not treated. On immunocytochemistry, cytoplasmatic SCF-reactivity was observed in HMC-1 cells, with additional cell membrane staining in KU-812, skin and cultured mast cells. However, embryonic SIX3 expression is not limited to the eye field, and SIX3 has been found to be mutated in some patients with holoprosencephaly type 2 (HPE2), suggesting that SIX3 has wide implications in head development. In this study, we used the mitochondrial gene Cytb and the nuclear gene RAG2 to investigate the species phylogeographical patterns and to test two biogeographic hypotheses: (1) that divergence between lineages supports the three-step model and (2) climatic fluctuations during the Quaternary resulted in the present distribution in southern China. These results suggest that the GABA(A) receptor is involved in the modulation of VLO morphine-induced antinociception, and provide a behavioral support for the hypothesis that morphine may directly inhibit the GABAergic inhibitory interneurons leading to indirect activation of the descending antinociceptive pathway through a disinhibitory effect on the VLO output neurons and depression of the nociceptive inputs at the spinal cord level.

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This information is critical for effective deployment of spatially targeted interventions and for understanding the mechanisms that drive the dispersal of the virus. Steady and dynamic rheological measurements are employed to characterize the pH-responsiveness at different pH. Incidence of xenobiotics among drivers killed in single-vehicle crashes. Age-, sex-, and body mass index (BMI)-adjusted intergroup comparison analyses showed a marked reduction in BMI and a significant reduction in muscle mass in the AE group when compared to the RT group and the DO group, respectively. Physician organizations begin making inroads in the health care marketplace. No specific physical symptom pattern or cluster was evident among those with these Axis II features. The prognostic value of the noninvasive vascular laboratory in autologous vein bypasses of the lower extremities. Cloning and characterization of a novel human phosphatidylinositol transfer protein, rdgBbeta.

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Physicians have an important role in recording and reporting ATV-related health hazards. In the presence of lovastatin, restoration of the net synthesis of apoB by 25-hydroxycholesterol was not accompanied by an increased VLDL output of apoB-48 and apoB-100. In order to estimate the level of airborne MDI in casting work, measurements were conducted also in two hospitals during the application and removal of synthetic plaster casts using the same method. Genetic analysis showed that the patient was a symptomatic heterozygote, which suggests that one lesion in the CFTR gene may be sufficient to cause CF-like lung disease. Methotrexate and misoprostol for early abortion in adolescent women. The 6-aza analogue of 5-(4-fluorophenyl)-3-hydroxypyridin-2(1H)-one (6-(4-fluorophenyl)-4-hydroxypyridazin-3(2H)-one) also retained modest activity as what drug reverses plavix an inhibitor. Although the level of expression of the sadC gene does not seem to be impacted by the regulatory cascade, the production of the SadC protein is tightly repressed by RsmA.

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Acute thermal injury (70 degrees C, 30 sec) to rat skin results in progressive consumptive depletion of the complement system. These results suggested that TGF-beta increased intracellular H2O2 through RhoA and phospholipase A2, and also suggested that indocin tablets intracellular H2O2 was required for the stimulation of stress fibre formation and DNA synthesis in response to TGF-beta. We conclude that chronic respiratory disease is independently associated with depression in Chinese elderly. Therefore, PKD3 is a pivotal mediator of the CaN-NFATc1/c3-PKD3-NFATc4 hypertrophic signaling cascade and a potential new drug target for the PCH. Ascosporulation in the yeast strain designated as Selenotila intestinalis Krassilnikov was achieved. None of these polypeptides formed dimers after chemical crosslinking. In the thyroidectomized patients significantly higher values of allopregnanolone have been found in the luteal phase. These results are shown to fit a saturation model which argues that as the click rate increases, the evoked neural activity moves from a response that is tonic toward one which is more phasic. We describe the technique and include some computer simulations as illustrative examples for x-ray optical component. Focusing on nonrandom patterns of behavior, we examined sequential patterns of team member monitoring and talking to the room in higher- and lower-performing action teams working in a high-risk health care environment.

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Effect of oral melatonin administration on sex hormone, prolactin, and thyroid hormone concentrations in adult dogs. Cyanamide pre-treatment had no effect on nitrophenol hydroxylase, 7-methoxy-, 7-ethoxy- or 7-benzyloxyresorufin O-dealkylase activities in 24 h cultures from untreated rats, and had no effect on intracellular glutathione content in cultures from untreated rats, or in cultures from isoniazid-treated rats in which cytochrome P4502E1 (CYP2E1) is increased. Association of vitamin D status with mental stress-induced myocardial ischemia in patients with coronary artery disease. The toxicity of heavy metals in plants can be alleviated by their complexation with sulfur compounds like phytochelatins or metallothiones, consisting of the major mechanisms of phytodetoxification. Expression of human (beta)3-adrenergic receptor induces adipocyte-like features in CHO/K1 fibroblasts. Assessing CNVs in Palauan extended pedigrees yields insight into the evolution of risk CNVs, such as how they arise, are transmitted, and are lost from populations by stochastic or selective processes, none of which are easily measured from case-control samples.

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Continuous light paradoxically reduces catecholamine-induced melatonin production. This effect could be totally reversed by the addition of mevalnate and geranylgeraniol but not farnesol. A risk map of the chemical/petrochemical industrial area of Tarragona (Catalonia, Spain) was designed following a two-stage procedure. The diversity of nitrogen-fixing microorganisms in three types of biological soil crusts (algal crust, moss crust and algal-moss crust) from two wastelands of copper mine tailings were investigated by polymerase chain reaction-denaturing gradient gel electrophoresis, based on the nifH gene of diazotrophs, to investigate: The diversity of nifH gene in the crusts of mine wastelands, and whether and how the nifH gene diversity in the crusts could be affected by the development of plant communities. Therefore we discuss whether meningitis was consequential or coincidental with spinal anaesthesia and could have been prevented by more comprehensive preoperative laboratory screening or prophylactic antibiotics. In a study of thirty-nine children with recurrent infections, circulating antigens, either free or in the form of immune complexes, were detected in thirty. Chromosomal deviations in subfertile men and their partners is often not a reason to refrain from intracytoplasmic sperm injection. Steady-state acceptor fluorescence anisotropy imaging under evanescent excitation for visualisation of FRET at the plasma membrane. To evaluate clinical and imaging factors for potential use in predicting appendix visualization ventolin hfa generic on sonography (US) of adult patients with suspected appendicitis.

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Mechanosensitive kinases regulate stiffness-induced cardiomyocyte maturation. Immunostaining with cytokeratins 7 and 20 attested the diagnostic and pointed out the spreading pattern of colorectal metastasis within biliary ducts. Brain excitability in stroke: the yin and yang of stroke progression. They take two major forms: interference with normal function, and oncogenesis. The comparison of calculations on isolated molecules with molecules in clusters demonstrates that intermolecular effects can be successfully modeled using a cluster that represents a local portion of the lattice structure, without the need to use periodic-boundary conditions (PBCs).

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The purpose of this study was to investigate changes in breathing pattern, neuromuscular drive (P0.1), and activity of the sternocleidomastoid muscles (SCM) during a gradual reduction in pressure support ventilation (PSV) in patients being weaned off controlled mechanical ventilation. Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40-TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage. Comparative reverse-transcriptase polymerase chain reaction and Western blotting revealed that arterial shear stress induced p38-dependent expression of monocyte chemotactic protein-1 and interleukin-8 in porcine jugular vein ECs. Moreover, the role of some highly conserved amino acids within members of the SLC4 family to which AE1 belongs has been assessed in AE1 transport properties. We report a patient adalat xl drug who developed facial edema after iv injection of midazolam during caesarian section. In general, predictive abilities similar to or higher than those within biparental families could be achieved by combining several half-sib families in the estimation set. The latency of the first phase was unchanged, but its amplitude increased. Here, we provide evidence that Arabidopsis MSI1 physically interacts with DDB1A and is part of a multimeric protein complex including CUL4. AI is clinically and genetically heterogeneous, there are sex linked and autosomal versions, dominant and/or recessive, with phenotypes of hypoplastic, hypocalcified or hypomature enamel. This article briefly outlines these hypotheses with particular regard to the fields of steatohepatitis and inflammatory bowel diseases.

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Several weeks after stopping agomelatine, the liver enzymes returned to normal. This review focuses on recent developments in the field of systems biology which use multidimensional data to discover biological networks affected by combat exposure and post-deployment disease states. Identification of biomarkers associated with improved efficacy may help select patients likely to receive the most benefit from these agents and may improve outcomes through development of personalized therapeutic strategies. In particular, we will review a recently proposed target, the microtubule-associated proteins (MAPs) encoded by doublecortin-like kinase gene (DCLK1). Expression of N2IC also caused epithelial-mesenchymal transition in SC-M1 cells. A mechanism of graft accommodation with concurrent inhibition of donor-specific immune memory is likely to be involved. Furthermore, guidelines to manage these wastes through technologies that minimise their environmental impact and lead to a sustainable use of resources are critical. The current study evaluated the degree to which startle reflexes (SRs) in safe conditions versus danger conditions were predictive of the onset of anxiety disorders. The present study included 229 patients suffering from colorectal cancer and 31 cases with benign colorectal diseases.

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Such an optimization problem is converted into the finite dimensional optimization problem using the control parametrization technique. Our results therefore provide experimental support for the similarity between particle dynamics in grain boundaries and in supercooled liquids as suggested by recent computer simulations. Ischemic brain injury may elevate the level of serum S100B protein and the severity of brain damage. To resolve the biggest problem in visible-to-UV photon upconversion based on sensitized triplet-triplet annihilation-the quenching of upconverted fluorescence by sensitizers-we discovered a superior sensitizer with less UV absorption intensity that enables highly efficient, low-power (0.78 mW cm(-2)) visible-to-UV upconversion. Increasing physician awareness of these side effects will allow for can i crush a zyrtec pill monitoring of bone health and therapeutic interventions to prevent or treat drug-induced osteoporosis.

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This research continues a systematic experimental analysis of the interaction between drug-controlled behavior and context. Nidogen-1 secretion to basement membranes by astrocytes may have important functional implications during blood-brain barrier and scar formation. A study with young indigenous people from different sociodemographic contexts. Solitary bone cysts (SBC) are uncommon non-neoplastic bone lesions, which present mainly in the mandible. Effects of aquifer heterogeneity and reaction mechanism uncertainty on a reactive barrier. The isolate also productively infected ferrets, with direct evidence of contact transmission, but no disease or transmission was seen in pigs. Arterial blood gas analysis and measurements of PetCO(2) were carried out during CO(2) insufflation in 16 patients who underwent posterior retroperitoneoscopic adrenalectomy in the prone position (PRA group). Whilst some prisoners found the interviews upsetting, nearly all said they were pleased to have participated.

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Both the magnitude and duration of the specific IgM responses in these calves were increased by pre-treatment with PGA. We show that physiological concentrations of TG similarly and significantly suppress TSH-increased NIS promoter activity, NIS protein, and NIS-dependent iodide uptake as well as RNA levels. The Abeta aggregates induced by Fe(III) ions had the greatest stability. A comparative study of the posterolateral and anterolateral approaches for isolated acetabular revision. brasilense produce siderophores, exhibiting different yields and rates of production according to their origin. This paper presents (1) a new scoring system for mapping spin systems to residues, (2) an automated adjacency information extraction procedure from NMR spectra, and (3) a very fast assignment algorithm based on our previous proposed greedy filtering method and a maximum matching algorithm to automate the assignment process. Also, a slight but significant increase of docosahexaenoic acid was observed in the phosphatidylethanolamine fraction as well as a significant increase of vitamin E level after the n-3 PUFA intake. The compensation process is based only on source current extraction that reduces the number of sensors as well as its complexity. A case of thanatophoric dysplasia type I with an R248C mutation in the FGFR3 gene.

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