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Baclof (Baclofen)

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Baclof is not FDA-approved for back pain, but providers will often prescribe it for this as well as other types of pain. This is considered an "off-label" use of Baclof. It might work for you if your back pain is caused by muscle spasms. If your pain is dull and achey or feels like pins and needles, it might not help much.

Other names for this medication:
Bacfen, Baclof, Baclofen, Bacmax, Chinofen, Liofen, Parafon, Riclofen, Spinofen, Spinospas, Tefsole

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Also known as: Baclofen


Baclofen is used to help relax certain muscles in your body. It relieves the spasms, cramping, and tightness of muscles caused by medical problems, such as multiple sclerosis or certain injuries to the spine. Baclofen does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition.

Baclofen acts on the central nervous system (CNS) to produce its muscle relaxant effects. Its actions on the CNS may also cause some of the medicine's side effects. Baclofen may also be used to relieve other conditions as determined by your doctor.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain baclofen. It may not be specific to Baclof. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, or do not take it longer than your doctor ordered.

Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For muscle relaxation: For oral dosage form (solution): Adults and children 12 years of age and older—At first, 5 milliliters (mL) three times a day for 3 days. Your doctor may increase your dose by 5 mL every 3 days as needed and tolerated. However, the dose is usually not more than 80 milligrams (mg) per day (20 mg four times a day). Children younger than 12 years of age—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults and teenagers—At first, 5 milligrams (mg) three times a day. Your doctor may increase your dose by 5 mg every 3 days until the desired response is reached. However, the dose is not more than 80 mg per day. Children—Use and dose must be determined by your doctor.


If you overdose Generic Baclof and you don't feel good you should visit your doctor or health care provider immediately.


Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the oral liquid in the refrigerator. Do not freeze.

Detailed Baclof dosage information

Side effects

The most common side effects associated with Baclof are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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The effect of antibiotic resistance on the eradication of Helicobacter pylori. Organizing pneumonia pattern in the follow-up CT of Legionella-infected patients. We asked if, during B cell activation, AID also induces DNA breaks at genes other than IgH genes. Several visualization techniques have been extensively researched. Two conformers of Al(6) with very distinct shapes, i.e., the spherical O(h) and planar C(2)(h) clusters, are considered in this work. Tests to diagnose or exclude specific sexually transmitted infections are seldom ordered and symptomatic management is common. Can topical beta blockers be successful for acute migraine management?. We explore the effects of various thresholds for removing data in experiments of different size (from 3 to 10 arrays per treatment), as well as their relative power to detect significant differences in expression. Search for a curvilinear relationship between the sense of coherence and the intensity of PTSD in MVA survivors. A questionnaire about the discomfort level in speech production was applied.

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Thirty MR imaging examinations (14 boys, 16 girls) which were interpreted as normal constituted the control group. Height, weight, BMI, body composition, waist circumference, dietary intake, blood lipids and lipoprotein concentrations, blood glucose concentrations, and resting blood pressure were measured to enhance student awareness of cardiovascular disease risk factors. Evaluation of effectiveness of combined sewer overflow control measures by operational data. Phorbol ester tumor promoters activate protein kinase C (PKC) isozymes and novel non-kinase receptors, suggesting a high degree of complexity in the signaling mechanisms of tumorigenesis. Furthermore, grade changes can be identified earlier than differences in motility loss between samples. Auscultation of bowel sounds in patients with suspected acute appendicitis--an aid in the diagnosis?.

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Human papillomavirus 16 (HPV 16) and HPV 18 antibody responses measured by pseudovirus neutralization and competitive Luminex assays in a two- versus three-dose HPV vaccine trial. Progression-free survival (PFS), which measures the time to disease progression or death, is unaffected by postprogression therapies but does not evaluate the long-term impact of investigational treatments on tumor biology and responses to future therapies. An unusual finding was an increase in cortical bone porosity induced by RSG, consistent with its effect on long bones of women. We conclude that the presence of BB suggest decreased BMD and when correlated with other clinical information, might support further evaluation of BMD. Free iron in haemoglobin, iron-mediated free radical reactions and carbonyl formation in haemoglobin were pronounced in diabetes, and were counteracted by glycyrrhizin. Animal studies suggest that deep dermal and/or subcutaneous delivery may be facilitated by both dermal diffusion and transport via the cutaneous vasculature. We identified 10 clusters of differentially expressed miRs, which contain putative markers and regulators of mesodermal differentiation and cell fate determination into adipocytes. Differences in evolutionary history translate into differences in invasion success of alien mammals in South Africa. A paleozoological perspective on unionid (Mollusca: Unionidae) zoogeography in the upper Trinity River basin, Texas. However, surgical repairs had carried, not only complication, but a risk of recurrence due to recanalization of the previously ligated ICA.

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Potentially life-threatening hypophosphatemia in anorexia nervosa. Backflow was measured using two methods: i) at the point of pressure stabilization within the catheter, and ii) maximum backflow as shown by video data. Synthesis and antimalarial activity of thioetherhydroxyethylsulfonamides, potential aspartyl protease inhibitors, Part 3. External anal sphincter atrophy on endoanal magnetic resonance imaging adversely affects continence after sphincteroplasty. The anti-ulcer activities of atropine, FPL 52694 and cimetidine are discussed in relation to their gastric anti-secretory actions. The regimens used included dapsone, colchicine, mesalazine, cyclosporine, mycophenolic acid, intravenous immunoglobulin, rituximab, daclizumab, extracorporeal photochemotherapy, and plasmapheresis. Extracorporeal photopheresis (ECP) is considered to be a promising immunomodulatory therapy in diseases caused by aberrant T lymphocytes. The results suggest that certain what type of medication is cardizem aspects of force platform data may have predictive value for subsequent falls, especially various indicators of the lateral control of posture. Similarly, the ligand data was processed using MGL (Molecular Graphics Laboratory) and chimera tools and saved in PDB format.

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This case study highlights a unique presentation of an 8-year-old girl with a globe rupture. To better understand the function of these proteins, we have generated a battery of mutations in five putative RNA helicases involved in 18S rRNA synthesis and analyzed their effects on cell growth and pre-rRNA processing. Radiological aspects of the wrist and hand in chronic polyarthritis in the adult and in ankylosing spondylarthritis. These findings indicate that ONO-1078 suppresses the production of IL-4 (a cytokine that affects IgG antibody production), IL-5, and GM-CSF (cytokines that affect eosinophil activation) by peripheral blood mononuclear cells under stimulation with specific antigens in patients with bronchial asthma. FGP assessment of postural disorders during the process of rehabilitation. A second experiment demonstrated that the usefulness of the present procedure for determining temporal bisection points is limited to cases in which the longer interval is no more than four times the duration of the shorter interval. Extended degree and continuing education preferences of California public health professionals.

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Using such data, computational and mathematical models help identify key deregulated functions and processes, establish predictive biomarkers and optimize therapeutic strategies. Thirteen IgG monoclonal antibodies to the envelope protein of 17D yellow fever virus (17D YF) were produced. This suggested that IAPs upregulation was responsible for RA-FLS sensitivity to Smac 066. Adjuvant antibiotic, hyperbaric oxygen, antitoxin, local, and supportive therapies aid in treatment. Fast, transient cardiac accelerations and decelerations during fear conditioning in rats. Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort. The Serbian version of the Australian pelvic floor questionnaire is a reliable and valid instrument for assessment of quality of life in women with pelvic floor disorders. We analytically derive the change in exciton fine structure splitting (FSS) under external stresses in self noroxin drug class -assembled InAs/GaAs quantum dots, using the Bir-Pikus model. At the current writing, serum markers and imaging methods are available and increasingly in use as alternatives to biopsy.

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Gene expression was however sufficiently high for three of the genes to elicit antibody responses specific to the recombinant protein following a single dose of the live Toxminus vector vaccine. Decidual cast describes the spontaneous sloughing of endometrium as an entire piece while retaining the shape of the endometrial cavity. Mammalian cell-cycle progression is regulated by the combined action of cyclins/cyclin-dependent kinases (cdks) and cdk inhibitors. A case report of left ventricular-right atrial communication with infective endocarditis. Elastographic techniques conceived to assess liver stiffness, in particular transient elastography, and the most commonly used biological markers will be assessed against their respective role and limitations in staging hepatic fibrosis. Glyphosate as an acetylcholinesterase inhibitor in Cnesterodon decemmaculatus. The arteriovenous fistula was reconstructed, but obstruction recurred twice within several hours after surgery.

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Serotype distribution and antibiotic susceptibility of Streptococcus pneumoniae strains carried by children infected with human immunodeficiency virus. Bone morphogenetic protein-2 (BMP-2) and Wnt are involved in the normal development and tumorigenesis of several organs, and in the development of skin and skin appendages as a morphogen. We present a simple valve model that predicts valve motion on the basis of this pressure difference, and can be used to investigate not only valve pathology, but a wide range of cardiac and vascular factors that are likely to influence valve motion. Recently, induced pluripotent stem cells (iPS cells) have been derived from various techniques and show great potential for therapy of human diseases. A cell line, DE-1, was established by infecting the decidual fibroblasts with the simian virus 40 large T antigen. Our findings show that phacoemulsification using the SWS system results in lower peak temperatures and less temperature change at the phaco wound site compared with the LAD system. We report the first fosamax weekly missed dose instance of generalized papular umbilicated granuloma annulare in an 11-year-old boy, which cleared following bath psoralen plus ultraviolet A therapy. Quantitative PCR revealed growth in the tfdA-containing bacterial community, from 500 genes g(-1) soil to approximately 3 x 10(4) genes g(-1) soil and to 7 x 10(5) genes g(-1) soil for topsoil initially added to 2.3 mg MCPA kg(-1) (dry weight) soil and 20 mg MCPA kg(-1) (dry weight) soil, respectively.

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This paper presents a family therapy approach to the treatment of an obsessive-compulsive child. Snow Catastrophe Conditions: What is its Impact on Orthopedic Injuries?. To establish the therapeutic potential of this observation, the authors address two questions: first, whether clinically more relevant steroid manipulations after ischemia exert similar protective effects, and second, whether changes in synaptic functioning occur along with structural alterations. Our data with other compounds suggested that biguanides combined with EGFR inhibitors have the potential to outperform other targeted drug combinations and could be employed in other breast cancer subtypes, as well as other tumor types, with activated EGFR and PI3K signaling. Non-neoplastic foci of skeletal muscle cells are rarely noted within human central nervous system. Third, children should learn how to handle bullying situations and develop resilience against bullying. The present results both indicate that RA-BMNC are nurse cells and suggest that they may play an important role in the pathogenesis of RA. The efficacy of immunotherapeutic strategies for the treatment of lymphoid malignancies has been demonstrated in recent years. More specifically, our understanding of the central role of the ADAMTS13 protease in the pathophysiology of TTP has allowed ADAMTS13 testing to have a more prominent role in confirming or re-evaluating the clinical diagnosis of idiopathic TTP with the finding of severely deficient or measurable ADAMTS13, respectively. In vitro and intracellular activities of peptide deformylase inhibitor GSK1322322 against Legionella pneumophila isolates.

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During the treatment massive polyploidization was demonstrated to be, in general, the second response of treated cells overcoming an initial proliferative block in the G 2 phase of their life cycle. Rates of immediate postoperative instillation chemotherapy were lower than expected. Inflammation involves the activation of a highly coordinated gene expression program that is specific for the initial stimulus and occurs in a different manner in bystander parenchymal cells and professional immune system cells recruited to the inflamed site. The professional socialization of the nurse in contemporary society. These findings suggest that standardized case definition was feasible in clarifying the AEFI data, and to further increase the understanding of possible relationship of influenza vaccine and GBS. Sensitivity and image resolution studies are performed in simulations and in experiments and compared to a simulated spherical detector. A total of 150 students from three consecutive batches from basic and clinical sciences were included in the study. Identification of a tandem duplicated array in the Rhox alpha locus on mouse chromosome X. Sulfate encapsulation in a metal-assisted capsule based on a mono-pyridylurea ligand. The preliminary psychometric properties of the measure showed acceptable results.

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Over time, as clinical importance of this phenomenon has begun to be fully considered, scientists have highlighted more and more physiopathological mechanisms and signaling pathways that underlie VC. Effect of reproductive characteristics, body mass index, and anterior/posterior vaginal compartment defects on the short-term success of abdominal sacrocolpopexy. Indications for thoracoplasty and pulmonary resection in the supine position. In this first article of what is planned to be an annual series, we examine the history of cancer prevalence reporting and the role that these annual figures play in guiding the direction of cancer control research, and specifically the science of cancer survivorship. Oxidative macromolecular alterations in the rat central nervous system in response to experimentally co-induced chlorpyrifos and cold stress: a comparative assessment in aging rats. Benda and Urquia granulograms in differential diagnosis of osteoarticular tuberculosis. Ischemia/reperfusion (I/R) injury is characterized by the production of oxygen-free radicals leading to disturbances in vasomotility (microvascular constriction) and microvascular permeability (interstitial edema formation). The approach is rapid and virtually traceless, because the intein removes itself during the reaction. Twelve hyperandrogenic anovulatory patients and 11 healthy women matched by body mass index amoxil normal dose and waist to hip circumference ratio. Our study shows that high-dose GH treatment in short SGA children results in high serum GH and IGF-I levels in most children.

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