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Azrolid (Azithromycin)
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Azrolid

Azrolid is a macrolide antibiotic of azalides group. Azrolid contains Azithromycin as an active ingredient. Azrolid inhibits RNA-dependent protein synthesis of sensitive microorganisms. It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes group A); gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.

Other names for this medication:
Azadose, Azicid, Azihexal, Azimax, Azimycin, Azithin, Azithrocin, Azitrix, Azitrom, Azomac, Azomex, Azomycin, Bactrazol, Faxin, Imbys, Kromicin, Mezatrin, Misultina, Momicine, Naxocina, Ribotrex, Ricilina, Simpli, Texis, Tridosil, Unizitro, Zentavion, Zirocin, Zithrin, Zitrocin, Zitroneo

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Also known as: Azithromycin

Description

Azrolid (Azrolid tablets and Azrolid for oral suspension) contain the active ingredient azithromycin, a macrolide antibacterial drug, for oral administration. Azrolid has the chemical name (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl) oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one. Azrolid is derived from erythromycin; however, it differs chemically from erythromycin in that a methyl-substituted nitrogen atom is incorporated into the lactone ring. Its molecular formula is C38H72N2O12, and its molecular weight is 749.00.

Azrolid, as the dihydrate, is a white crystalline powder with a molecular formula of C38H72N2O12∙2H2O and a molecular weight of 785.0.

Azrolid is supplied as tablets containing azithromycin dihydrate equivalent to either 250 mg or 500 mg azithromycin and the following inactive ingredients: dibasic calcium phosphate anhydrous, pregelatinized starch, sodium croscarmellose, magnesium stearate, sodium lauryl sulfate, hypromellose, lactose, titanium dioxide, triacetin, and D&C Red #30 aluminum lake.

Azrolid for oral suspension is supplied in bottles containing azithromycin dihydrate powder equivalent to 300 mg, 600 mg, 900 mg, or 1200 mg azithromycin per bottle and the following inactive ingredients: sucrose; sodium phosphate, tribasic, anhydrous; hydroxypropyl cellulose; xanthan gum; FD&C Red #40; and spray dried artificial cherry, creme de vanilla, and banana flavors. After constitution, each 5 mL of suspension contains 100 mg or 200 mg of azithromycin.

Dosage

Use Azrolid as directed by your doctor.

Take Azrolid by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.

Do not take an antacid that has aluminum or magnesium in it within 1 hour before or 2 hours after you take Azrolid.

Azrolid works best if it is taken at the same time each day.

To clear up your infection completely, use Azrolid for the full course of treatment. Keep using it even if you feel better in a few days.

Ask your health care provider any questions you may have about how to use Azrolid.

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.

Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Azrolid Tablet.

Side effects

The most common side effects associated with Azrolid are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Azrolid IV if you are allergic to it, or if you have ever had:

jaundice or liver problems caused by taking Azrolid IV; or a severe allergic reaction to similar drugs such as clarithromycin, erythromycin, or telithromycin.

Azrolid IV oral should not be used to treat pneumonia in people who have:

cystic fibrosis; an infection after being in a hospital; an infection in the blood; a weak immune system (caused by diseases such as HIV/AIDS or cancer); or in older adults and those who are ill or debilitated.

Tell your doctor if you have ever had:

pneumonia; liver or kidney disease; myasthenia gravis; low levels of potassium in your blood; a heart rhythm disorder; or long QT syndrome (in you or a family member).

It is not known whether this medicine is effective in treating genital ulcers in women.

Tell your doctor if you are pregnant or breastfeeding. Taking Azrolid IV while breastfeeding may cause diarrhea, vomiting, or rash in the nursing baby.

Azrolid IV is not approved for use by anyone younger than 6 months old. This medicine should not be used to treat a throat or tonsil infection in a child younger than 2 years old.

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Generic phase diagram of Fermion superfluids with population imbalance. Sealing Efficacy of Single-cone Obturation Technique with MTA and CEM Cement: An in Vitro Bacterial Leakage Study. Factors Associated with Self-rated Health of Rural Population: A Report from the Prospective Observational Study. These results raise the possibility that TAK1 and NLK are also involved in Wnt signalling in mammalian cells. Pancreatitis-an inflammation of pancreas-is a severe and costly disease. Reverse transcription-quantitative polymerase chain reaction and western blotting revealed that the expression levels of Bax and poly(ADP-ribose) polymerase-1 (PARP-1) were upregulated in the I/R group, whereas those of Bcl-2 were downregulated. Lately, a growth inhibiting effect could be detected in human renal cell carcinoma-cell lines as well. Two reviewers independently selected parallel group randomised controlled trials comparing nitric oxide with control and extracted data related to study methods, clinical and physiological outcomes, and adverse events. The enzyme preparations had specific activities similar to previously reported values. Identical studies were performed with 20-hydroxyecdysone and testosterone, which served as positive controls for ecdysteroid receptor agonism and antagonism, respectively.

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Even when there is no significant inflammatory infiltrates, such as in Parkinson or Alzheimer disease, there is intense activation of microglia with resultant elevation of many inflammatory mediators within the CNS. These different steady states, with different cell concentration, also have different productivity. Information was obtained on self-reported and cotinine validated smoking status, cigarette dependence, motivation to stop smoking, COPD defined by spirometry using joint American Thoracic Society and European Respiratory Society criteria, and self-reports of diagnosis with respiratory disorders. We assayed the pharmacological effects and mechanisms of the action of sirtinol in human neutrophils, and in neutrophil elastase (HNE)-induced paw edema and lipopolysaccharide (LPS)-mediated ALI in mice. The representative average size of PP/DNA complex prepared using plasmid DNA (pEGFP-N1, pDNA) was about 96 nm. motivational interviewing, cognitive-behavioural therapy, and self-control training). Application of proteomics for the characterization of biological allergen extracts. She was treated with co-trimoxazole and afterwards she underwent a cholecystectomy and common bile duct exploration.

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In our study, protein microarrays were generated by printing antibodies onto membranes to characterize protein profiles expressed by head and neck squamous cell carcinomas (HNSCCs). Although certain immunologic studies suggest immune complex mechanisms in HP, recent experimental and clinical data accumulated support a role for cell-mediated immunity. In general, the best network is selected after a number of optimization trials. In the present paper we describe two cases showing the possibility of making diagnostic mistakes, and especially illustrating the role ofbronchoscopy in differential diagnosis of bronchial asthma. Mutations in the sqt-1 and rol-6 cuticle collagen genes of Caenorhabditis elegans can cause dramatic alterations in organismal morphology. Infection with M tuberculosis as such is not incompatible with a prominent IgE response. Differential phase-contrast imaging with hard x rays can have important applications in medicine, material sciences, and energy research. The rates of 3-H-proline incorporation by the rat periodontal ligament, the gingival connective tissue and the dental pulp were studied by autoradiography. Six-week interruption of the administration of oral vitamin E in CAPD patients led to the significant decrease of erythrocyte superoxide dismutase and plasma vitamin E.

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To compare the safety and efficacy of silicone and polypropylene Ahmed glaucoma drainage devices. Electron microscopy results showed that in and below the injuryed segment, the inflammation and demyelination of neural tissue were alleviated, apoptotic cells were reduced, and injured Schwann cells and myelin fibers were repaired. By the qualitative differences in the adsorption of cellulases on lingo-cellulosics, a new cellobiohydrolase (CBH) with apparent molecular mass of 194 kDa was isolated and characterized. The aim was to determine whether MMP7 cleaves galectin-3 and modulates wound healing in intestinal epithelial cells. Expression of collagen type II was also detected at the mRNA level by means of coupled reverse transcription/polymerase chain reaction. The FACE trial: letrozole or anastrozole as initial adjuvant therapy?.

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Prevention of progressive renal function loss and its complications remains the main challenge in clinical nephrology. A regression approach to the analysis of serial peak flow among fuel oil ash exposed workers. All VEMP testing was completed in semi-recumbent and inverted conditions. Moreover, the competitive binding mechanism of this probe would presumably minimize the effects on the electrophysiological properties of the hERG channel. In situ electrokinetic remediation of As-, Cu-, and Pb-contaminated paddy soil using hexagonal electrode configuration: a full scale study.

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Delayed repair of obstetric injuries of the anorectum and vagina. Moreover, phase imaging can serve as a real time contrast enhancement technique to TM-AFM in terms of highlighting edges and clearly observing fine features. The meta-analysis was conducted on peak voxel coordinates using an activation likelihood estimation approach. Neurosecretion and PAS-positive mucopolysaccharides in hypothalamic neurons of heifers after melengestrol acetate administration. Antegrade pyelography before pyeloplasty via dorsal lumbar incision.

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An accelerated proximal gradient method is adapted to estimate the optimal noise-free image patches. Leadership training to improve adenoma detection rate in screening colonoscopy: a randomised trial. Analysis of expressed sequence tags from a naked foraminiferan Reticulomyxa filosa. The authors studied 20 aspiration cases, all with histopathologic confirmation, and also conducted immunohistochemistry and/or molecular studies. The Gag-EF1alpha interaction appears to be mediated by RNA, in that basic residues in MA and NC are required for binding to EF1alpha, RNase disrupts the interaction, and a Gag mutant with undetectable EF1alpha-binding activity is impaired in its ability to associate with tRNA in cells. A 50-year-old woman presented with mid-thoracic back pain that radiated to the left rib cage in a radicular manner. Osmotic shock inhibits insulin signaling noroxin 400 mg plm by maintaining Akt/protein kinase B in an inactive dephosphorylated state. Smoking among male medical sciences students in Semnan, Islamic Republic of Iran. However, EIT has a number of practical problems relating to the placement of electrodes on the body.

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Secondary corrective bone surgery: osteodistraction and osteotomies. Tumor margins were well demarcated, except in three cases, two of which had large infiltrative tumors. The messages for these molecules were downregulated at the onset of recovery. Influence of hypertension and lipidemia on arterial lipid accumulation. The primary structure of a human MAP kinase activated protein kinase 2.

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In contrast, the current threshold to evoke saccades from the FEFs was only three times greater when stimulation was delivered under similar conditions. Simulation modifies prehension: evidence for a conjoined representation of the graspable features of an object and the action of grasping it. Endothelial cell dysfunction is a term which implies the dysregulation of normal endothelial cell functions, including impairment of the barrier functions, control of vascular tone, disturbance of proliferative and migratory capacity of endothelial cells, as well as control of leukocyte trafficking. From January 2007 to December 2007, we prospectively enrolled 524 consecutive adults who were scheduled to undergo EUS. Seven months later, the rats were subjected to transient cerebral ischemia using the four-vessel occlusion technique. In comparison with controls, LM patients had lower scores in Letters and Category Fluency and IP patients in Category Fluency.

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A 40-year-old multigravida presented at 24 weeks of gestation with metastatic breast cancer. Specific remedy recommendations for the treatment of leg cramps and other pregnancy-induced discomforts, such as anemia, herpes, nausea and hyperemesis, ptyalism, and pica are included. Leukotrienes are thought to contribute to the pathophysiology of asthma. The first transmembrane domains of truncated alpha and delta subunits are required for heterodimer formation in vivo. We detected 16S ribosomal DNA sequences similar to those of Cardinium from seven populations of five spider mite species, suggesting a broad distribution of infection of Cardinium in spider mites. These data demonstrate that while phosphorylation of beta c tyrosine residues 577 and 612 are important for optimal cell proliferation, rescue from apoptosis dulcolax stool softener tablet can be mediated by alternative signalling routes apparently independent of PKB or ERK activation. Competition between acetate and oleate for the formation of malonyl-CoA and mitochondrial acetyl-CoA in the perfused rat heart. The enhanced TF fluctuations yield results different from those in the deterministic case.

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