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Azold (Zolpidem)

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Azold is a drug that's used to treat insomnia. Insomnia is a sleep disorder that makes it difficult for you to go to sleep, stay asleep, or both. Azold is in a class of drugs called sedative-hypnotics. They work by slowing the activity in your brain, which allows for a state of sleep.

Other names for this medication:
Ambiz, Ambulax, Azold, Dactive, Getrest, Insom, Inzofresh, Isodem, Kayzole, Lipidem, Lopitas, Lypin, Nidra, Nitrest, Olpid, Restem, Sobrium, Stilnoct, Syzol, Zanlop, Zedem, Zodem, Zolax, Zolcent, Zoldem, Zolep, Zolfresh, Zolip, Zolit, Zolnex, Zolojet, Zolpel, Zolpiapt, Zolpid, Zolpidem, Zolpimist, Zolpirest, Zolpistar, Zolpitrac, Zolsoma, Zoltar, Zolway, Zomnia, Zopid

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Trileptal, Terramycin, Mysoline, Pepcid, Protonix, Dilantin, Wellbutrin, Metsig, Etophylate, Alzopam, Sigaprim, Sycyp, Alzine, Lotweet, Morecalm, Xifen, Yaxinbituo,

Also known as: Zolpidem


Zolpidem is used to treat insomnia (trouble sleeping). It belongs to the group of medicines called central nervous system (CNS) depressants, which slows down the nervous system. Zolpidem will help you get to sleep faster and sleep throughout the night. In most cases, sleep medicines should only be used for short periods of time, such as 1 or 2 days, and for no longer than 1 or 2 weeks.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain zolpidem. It may not be specific to Azold CR. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much is taken, it may become habit-forming (causing mental or physical dependence).

This medicine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Take zolpidem just before going to bed, when you are ready to go to sleep or when you are having trouble falling asleep. This medicine works very quickly to put you to sleep.

Swallow the extended-release tablet whole. Do not divide, crush, or chew it.

Do not take this medicine when your schedule does not permit you to get a full night's sleep (7 to 8 hours). If you must wake up before this, you may continue to feel drowsy and may experience memory problems, because the effects of the medicine have not had time to wear off.

Take this medicine on an empty stomach.

Do not take this medicine if you have drank alcohol the same evening or just before bedtime.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of insomnia: For oral dosage form (extended-release tablets): Adults—6.25 milligrams (mg) (for women) or 6.25 or 12.5 mg (for men) once a day at bedtime. Your doctor may increase your dose as needed. However, do not take more than 12.5 mg per day. Take only 1 dose a night as needed. Older adults—6.25 mg once a day at bedtime. Children—Use is not recommended. For oral dosage form (tablets): Adults—5 milligrams (mg) for women and 5 or 10 mg for men once a day at bedtime. Your doctor may increase your dose as needed. However, do not take more than 10 mg per day. Take only 1 dose a night as needed. Older adults—5 mg once a day at bedtime. Children—Use is not recommended.


In postmarketing experience of overdose with Azold tartrate alone, or in combination with CNS-depressant agents, impairment of consciousness ranging from somnolence to coma, cardiovascular and/or respiratory compromise, and fatal outcomes have been reported.

General symptomatic and supportive measures should be used along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed. Azold's sedative hypnotic effect was shown to be reduced by flumazenil and therefore may be useful; however, flumazenil administration may contribute to the appearance of neurological symptoms (convulsions). As in all cases of drug overdose, respiration, pulse, blood pressure, and other appropriate signs should be monitored and general supportive measures employed. Hypotension and CNS depression should be monitored and treated by appropriate medical intervention. Sedating drugs should be withheld following Azold overdosage, even if excitation occurs. The value of dialysis in the treatment of overdosage has not been determined, although hemodialysis studies in patients with renal failure receiving therapeutic doses have demonstrated that Azold is not dialyzable.

As with the management of all overdosage, the possibility of multiple drug ingestion should be considered. The physician may wish to consider contacting a poison control center for up-to-date information on the management of hypnotic drug product overdosage.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Azold CR dosage information

Side effects

The most common side effects associated with Azold are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Avoid taking Azold during travel, such as to sleep on an airplane. You may be awakened before the effects of the medicine have worn off. Amnesia (forgetfulness) is more common if you do not get a full 7 to 8 hours of sleep after taking Azold.

Avoid driving or hazardous activity until you know how zolpidem will affect you. You may still feel sleepy the morning after taking Azold, and your reactions could be impaired. Wait until you are fully awake before you drive, operate machinery, pilot an airplane, or do anything that requires you to be awake and alert.

Do not take this medicine if you have consumed alcohol during the day or just before bed.

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In AR siRNA-transfected cells, tanshinone IIA did not cause cell cycle arrest and reduce cyclin D1, implying that AR is essential to induce G1 arrest by tanshinone IIA in LNCaP cells. This capability is expected to improve our understanding and management of retinal disease. Probe dependent anomalies in the solvation dynamics of coumarin dyes in dimethyl sulfoxide-glycerol binary solvent: confirming the local environments are different for coumarin dyes. In the present study, the effects of GDNF on postnatal ENS development were investigated using cultures of myenteric plexus from the small intestine of newborn albino rats of different developmental phases (P1, P7, P14). Clinical chemistry equipment: a computerized system for cost evaluation. The baseline survey was conducted in 1989 and the survival status of the respondents was ascertained during the subsequent 4 years. In this paper we make the original proposal of adopting a multiagent paradigm, called anthropic agency, to provide a powerful and flexible tool for combining partial models of heart rate regulation for adaptive cardiac pacing applications. Analysis of taste threshold distributions revealed significant variability, both within and between these two samples.

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Improving diagnostic accuracy of bacterial pharyngitis by near patient measurement of C-reactive protein (CRP). Synthesis, interaction with DNA and antiproliferative activities of two novel Cu(II) complexes with norcantharidin and benzimidazole derivatives. The relative activities of dextran, mannan and ovomucoid as agents inducing anaphylactoid responses in rats vary with the route of injection, mannan being the most active especially by the intradermal route. Moreover, we constructed a large comprehensive database of ligand binding pockets that will be searched against by a query. This is true for colorectal cancer in which mutations in signaling mediators predict resistance to anti-epidermal growth factor receptor (anti-EGFR) therapy. Here, a case of migratory bone marrow edema syndrome in a 47-year-old male patient, which was conservatively managed, is reported. communities of the Racial and Ethnic Adult Disparities in Immunization Initiative.

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Mating success of wild type and sepia mutants Drosophila melanogaster in different choice. Neurodegenerative diseases are characterized by intra- and/or extracellular protein aggregation and oxidative stress. Simvastatin potently stimulated leiomyoma cell apoptosis in a manner mechanistically dependent upon apoptotic calcium release from voltage-gated calcium channels. Although statins improve lipid profiles and reduce testosterone levels in women with PCOS, there is no evidence that statins improve resumption of menstrual regularity or spontaneous ovulation, nor is there any improvement of hirsutism or acne. There are regional differences in hip fracture incidence that cannot be explained by a north-south gradient in Norway. Transcatheter intervention for PAS in ALGS is generally safe and acutely effective. Approximately 1 ml urine was sampled using the mid-stream catch technique. The fragmented mitochondrial ribosomal RNAs of Plasmodium falciparum have short A tails. Characterization of the contributions of Hp-MMP 9 to the serum acute phase protein response of lipopolysaccharide challenged calves.

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Exciplex ensemble modulated by excitation mode in intramolecular charge-transfer dyad: effects of temperature, solvent polarity, and wavelength on photochemistry and photophysics of tethered naphthalene-dicyanoethene system. The peripheral artery questionnaire (PAQ) is a disease-specific health status measure of patients with peripheral artery disease (PAD). During thyroidectomy, the most common cause of UVFP, the superior laryngeal nerve (SLN), is also at risk of injury. The main feature of organ fibrosis is the excessive accumulation and deposit of extracellular matrix, thereby leading to organ dysfunction, loss of elasticity, and development of a rigid organ. Pulp reaction to the insertion of self-curing acrylic resin filling materials. Health care absorbs large private expenditures, sustained by households, remittances, charitable and solidarity funding, and constitutes a substantial portion of the country economy. Fracture risk in glucocorticoid-induced osteoporosis: comment on the article by Grossman et al. Participants found the study useful and believed that it would be of help in future critical appraisal. The rPLD1b mRNA increased within 6 h following dbcAMP treatment and maintained a high level up to 24 h. Experiments on both synthetic and real data highlight the benefit of considering fiber based statistical tests compared to the standard voxelwise strategy.

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The history and examination of patients with orbital tumors are discussed and the clinical presentation of various orbital tumors is presented. The mean number of OUs was always lower than half the number of PT: 10.4 at 24 PT, 7.2 at 20 PT, 4.4 at 16 PT, and 1.3 at 10 PT. Twenty two years later the tumour recurred and showed a rapid growth due to malignant transformation which we believe is late effect of radiotherapy. SCARF syndrome is a very rare syndrome that so far only two cases have been reported in the papers. The purpose of the study was to determine if first rib fractures are associated with an increased incidence of thoracic vascular injury in pediatric patients.

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The C-H activation was effected by photoexcited benzophenone, and the generated carbon radical was subsequently trapped with tosyl cyanide to afford the corresponding nitrile in a highly efficient manner. This article thus seeks to reintroduce trust as a fundamental element in answering the problem of disunity in the sociology of knowledge. When is surgery indicated for the control of supraventricular tachycardia?. Except for a HERV-R env sequence derived from gorilla DNA, the functional domains of putative envelope proteins are conserved, suggesting that those domains could have a functional capacity in the primate genome. Cadralazine (ISF 2469): dose-related antihypertensive activity after single oral administration to patients. Because microglial cells are both a major source of inducible nitric oxide synthase (iNOS)/nitric oxide (NO) production locally in the injured brain and are activated by NO-mediated injury, we tested whether iNOS inhibition reduces microglial activation and ischemic injury in a neonatal focal ischemia-reperfusion model. It is currently unknown whether genomic and molecular damage that occurs in HSCs induced by telomere shortening is transmitted to the progenitor cells. By in situ hybridization and immunohistochemistry herpesvirus DNA and protein, respectively, were detected within keratinocytes containing inclusion bodies. Sharpening of periodontal instruments with different sharpening stones and its influence upon root debridement--scanning electronic microscopy assessment. Such strain differences may be due to different susceptibilities to the nephrotoxic metabolite, p-aminophenol (PAP).

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The dynamic expression patterns of ZmLTPs family across the different developmental stages showed that several of them exhibit tissue-specific expression, indicative of their important roles in maize life cycle. Arabidopsis thaliana seedlings expressing the chimeric gene gfp-map4 were exposed to the enhanced UV-B with or without SNP or c-PTIO pretreatment. Analysis of a patient with a cervical spinal cord stimulator presenting with a spinal cord injury. Regulation of cardiac contractility and glycolysis by cyclic nucleotides during hypoxia. By the characterization of their systematic behavior, among other conclusions, they report the method which better performs for the estimation of the number of diffusion peaks per voxel, also the method which better estimates the diffusion orientation. Synergy of LY2409881 with other drugs active in lymphoma was determined by calculating relative risk ratio (RRR) and combination index (CI). S-ICD is a new system for delivering lifesaving shock therapy in patients at risk of sudden cardiac death, without the need can you take flagyl and yeast infection medicine at the same time of intracardiac leads. ECT was shown to be efficacious for the treatment of severe psychiatric disorders in 21 case reports.

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Factors evaluated were patient demographics, diagnosis, duration of surgery, intra- and postoperative complications, recovery of bowel function and length of stay in hospital. A single examination was carried on in 11 subjects, the rest of the patients demanding from 2 to 3 examinations. Findings in humans are supplemented by observations from rodent models of schizophrenia. What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders. Effect of vitamin A deficiency on pulmonary and hepatic protective enzymes in rat. Moreover, consistent with theories about biochemically based physiological scaling, isometric scaling of whole-plant respiration rate to total nitrogen content is observed within and across all data sets, with a single relation common to all data. Detection of static and dynamic components of mechanical allodynia in rat models of neuropathic pain: are they signalled by distinct primary sensory neurones?. Older adults often show higher costs than young adults, and they tend to prioritize the motor domain. The effect of soil moisture levels on cultivars may be important in making an informed selection and the response of P.

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On follow-up CT, secondary omental infarcts progressively shrank and developed a well-defined, hyperdense rim around a fatty core. Poliomyelitis: historical facts, epidemiology, and current challenges in eradication. Novel nonsecosteroidal vitamin D mimics exert VDR-modulating activities with less calcium mobilization than 1,25-dihydroxyvitamin D3. Association of restrictive ventilatory dysfunction with the development of prediabetes and type 2 diabetes in Koreans. Long-term results of trabeculectomy in the Japanese: an analysis by life-table method. 214 diabetic patients and their partners participated in the cross-sectional study and were assessed on psychological morbidity (HADS) and marital adjustment (RDAS). Granulocyte macrophage colony-stimulating factor (GM-CSF, Csf2) is a growth factor for myeloid-lineage cells that has been implicated in the pathogenesis of atherosclerosis and other chronic inflammatory diseases.

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Patients in whom donepezil is ineffective or poorly tolerated may benefit from a switch to galantamine. In this exploratory study, we examine whether parents differ in their levels of blame or doubt for their child when sexually abused by adolescents versus adults. Analysis of EXAFS data measured on a material with a disordered local configuration environment around the absorbing atom can be challenging owing to the proliferation of photoelectron scattering paths that must be considered in rocaltrol tablet uses in hindi the analysis. subtilis, transcription activation by DeltaN9ComK was twofold lower than that by wild-type ComK, resulting from a five- to sixfold lower protein level of ComKDeltaN9. Fingerbreadth measurements are somewhat arbitrary, with significant inter-surgeon variability.

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In this research, fragmentations of partially deglycosylated glycopeptides were studied using a triple quadrupole mass spectrometer, and a quantification method that coupled our published identification strategy with multiple reaction monitoring-mass spectrometry (MRM-MS) analysis was developed to obtain site-specific quantification information of core fucosylated peptides. It was found that the initial trauma was most likely sustained at least two weeks before death, whilst a neurosurgical procedure was performed at least one week before death. The patient developed circulatory shock 6 hours after pericardiocentesis. Loss-of-function experiments reveal that BicC is required for serotonergic neurogenesis and for expression of ankAT-1 gene, which is essential for the formation of apical tuft cilia in the neurogenic ectoderm of the sea urchin embryo. In this study, we test the hypothesis that they may act as a repository for the synthesis of new peptides. Significance of changes in TNF-alpha and IL-10 levels in the progression of heart failure subsequent to myocardial infarction.

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