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Azitrobac (Azithromycin)
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Azitrobac

Azitrobac is a macrolide antibiotic of azalides group. Azitrobac contains Azithromycin as an active ingredient. Azitrobac inhibits RNA-dependent protein synthesis of sensitive microorganisms. It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes group A); gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.

Other names for this medication:
Amsati, Azadose, Azatril, Azenil, Azibiot, Azimex, Azithrex, Azithromycin, Azithrus, Azitrom, Azitrox, Azycyna, Binozyt, Cinalid, Disithrom, Doromax, Ericiclina, Hemomycin, Ilozin, Kromicin, Macrozit, Neblic, Novatrex, Opeazitro, Orobiotic, Pretir, Rarpezit, Ricilina, Tritab, Ultreon, Unizitro, Zedd, Zemycin, Zithrogen, Zitrocin, Zitroken, Zitrolid, Zitroneo, Zitrotek

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Also known as: Azithromycin

Description

Azitrobac is a semi-synthetic macrolide antibiotic of the azalide class. Like other macrolide antibiotics, Azitrobac inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of the bacterial 70S ribosome. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the process of translation. Its effects may be bacteriostatic or bactericidal depending of the organism and the drug concentration. Its long half life, which enables once daily dosing and shorter administration durations, is a property distinct from other macrolides.

Azitrobac is the local analog (generic) of more famous drug Azitrobac that has the same active substance (ingredient) and in result the same therapeutic effect. The main difference is that Azitrobac is registered by a small local pharmaceutical company. The presence of the same active substance guarantees an identical pharmaceutical (therapeutic) effect on the body.

It is possible to buy Azitrobac only in the pharmacies of the country where it is produced. With us, you can buy its more famous analog Azitrobac, which is approved by the FDA and is sold worldwide. The same active substance guarantees the identity of the drugs and the identity of the pharmaceutical properties (they have only different names and packaging, in which they are sold).

Dosage

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins. This medicine is given slowly, so the needle will remain in place for about an hour.

Your doctor may give you a few doses of this medicine until your condition improves, and then you may be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Detailed Azitrobac dosage information

Overdose

Adverse reactions experienced at higher than recommended doses were similar to those seen at normal doses particularly nausea, diarrhea, and vomiting. In the event of overdosage, general symptomatic and supportive measures are indicated as required.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not refrigerate or freeze the extended-release oral liquid. After water has been added to the powder, use the dose within 12 hours and throw away any unused liquid after your dose.

You may store the oral liquid at room temperature or in the refrigerator. Do not freeze the bottle. Do not keep the oral liquid for more than 10 days. Throw away any unused liquid after all doses are completed.

Side effects

The most common side effects associated with Azitrobac are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Ketolide allergy. History of cholestatic jaundice/hepatic dysfunction associated with prior use.

Pneumonia: oral treatment is for mild, community-acquired cases suitable for outpatient therapy only. Discontinue if signs/symptoms of hepatitis occur. Known QT prolongation, proarrhythmic conditions, clinically significant bradycardia: avoid. Allergic symptoms may recur after initial successful symptomatic treatment. Myasthenia gravis. Hepatic or renal impairment. Elderly. Pregnancy (Cat.B). Nursing mothers.

Avoid concomitant aluminum- or magnesium-containing antacids. Monitor with digoxin, phenytoin, warfarin. Monitor for azithromycin toxicity (eg, liver dysfunction, ototoxicity) with nelfinavir. Concomitant Class 1A (eg, quinidine, procainamide), or Class III (eg, dofetilide, amiodarone, sotalol) antiarrhythmics, or others known to prolong the QT interval: avoid.

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