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Azifast (Azithromycin)
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Azifast

Azifast is a macrolide antibiotic of azalides group. Azifast contains Azithromycin as an active ingredient. Azifast inhibits RNA-dependent protein synthesis of sensitive microorganisms. It active against gram-positive bacteria: Staphylococcus aureus, Streptococcus spp. (including Streptococcus pneumoniae, Streptococcus pyogenes group A); gram-negative bacteria: Haemophilus influenzae, Haemophilus parainfluenzae, Haemophilus ducreyi, Moraxella catarrhalis, Escherichia coli, Bordetella pertussis, Bordetella parapertussis, Borrelia burgdorferi, Neisseria gonorrhoeae, Campylobacter spp., Legionella pneumophila; anaerobic bacteria: Bacteroides fragilis.

Other names for this medication:
Altezym, Amovin, Azinix, Azithromycin, Azitral, Azitrotek, Aziwok, Aztrin, Azycyna, Azyth, Bactrazol, Bezanin, Cinalid, Goldamycin, Gramokil, Imbys, Misultina, Momicine, Neblic, Nifostin, Novozithron, Novozitron, Opeazitro, Oranex, Pretir, Sumamed, Tromic, Trozocina, Vectocilina, Zentavion, Zetamax, Zibramax, Zithrin, Zitroken, Zitrolab, Zocin

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Propecia, Lamictal, Trandate, Depakote, Ceclor, Jyotam, Radizone, Walibur, Etogesic, Atensia, Zepatrac,

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Also known as: Azithromycin

Description

Azifast is in a group of drugs called macrolide antibiotics. Azifast fights bacteria in the body. Azifast is used to treat many different types of infections caused by bacteria, such as respiratory infections, skin infections, ear infections, and sexually transmitted diseases. Azifast may also be used for purposes other than those listed in this medication guide.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Azifast Tablets and other antibacterial drugs, Azifast Tablets should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Azifast Tablets are a macrolide antibacterial drug indicated for the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions listed below.

Azifast is an antibiotic used to treat bacterial infections of the nose, throat, lungs, bronchitis, ear, skin, soft tissues, and sexually transmitted genital and urinary infections.

Azifast is a semi-synthetic macrolide antibiotic of the azalide class. Like other macrolide antibiotics, Azifast inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of the bacterial 70S ribosome. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the process of translation. Its effects may be bacteriostatic or bactericidal depending of the organism and the drug concentration. Its long half life, which enables once daily dosing and shorter administration durations, is a property distinct from other macrolides.

Dosage

This section provides information on the proper use of a number of products that contain azithromycin. It may not be specific to Azifast Tri-Pak. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

You may take Azifast® oral liquid or tablets with or without food.

Shake well the bottle of Azifast® oral liquid before each use. Measure your dose correctly with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

Measure the Zmax® extended-release oral suspension with a marked measuring spoon, syringe, or cup. You or your child must take this medicine within 12 hours after it has been mixed with water. It is best to take the Zmax® extended-release oral suspension on an empty stomach or at least 1 hour before or 2 hours after a meal. If your child does not use all of the medicine in the bottle, throw it away after you give the dose.

If you or your child vomits within one hour of taking the Zmax® extended-release oral suspension, call your doctor right away to see if more medicine is needed.

Keep using this medicine for the full treatment time, even if you or your child feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

If you are taking aluminum or magnesium-containing antacids, do not take them at the same time that you take Azifast®. These medicines may keep azithromycin from working properly. However, you can take antacids with Zmax®.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (extended-release suspension): For treatment of pneumonia: Adults—2 grams (g) once as a single dose. Children weighing 34 kilograms (kg) or more—Dose is based on body weight and must be determined by your doctor. The dose is usually 2 grams once a day, taken as a single dose. Children 6 months of age and older weighing less than 34 kg—Dose is based on body weight and must be determined by your doctor. The dose is usually 60 milligrams (mg) per kilogram (kg) of body weight once a day, taken as a single dose. For treatment of sinusitis: Adults—2 grams (g) once a day as a single dose. Children—Use and dose must be determined by your doctor. For oral dosage forms (suspension or tablets): For treatment of infections: Adults—500 to 2000 milligrams (mg) once a day, taken as a single dose. Depending on the type of infection, this may be followed with doses of 250 to 500 mg once a day for several days. Children 6 months of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 10 to 30 milligrams (mg) per kilogram (kg) of body weight once a day, taken as a single dose. Depending on the type of infection, this may be followed with doses of 5 to 10 mg per kg of body weight once a day for several days. Children younger than 6 months of age—Use and dose must be determined by your doctor. For treatment of pharyngitis or tonsillitis: Adults—500 milligrams (mg) on Day 1 (the first day), taken as a single dose. Then, 250 mg on Day 2 through Day 5. Children 2 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 12 milligrams (mg) per kilogram (kg) of body weight once a day for 5 days. Children younger than 2 years of age—Use and dose must be determined by your doctor.

Overdose

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an Azifast overdose may include nausea, vomiting, diarrhea, and stomach discomfort.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Azifast are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Azifast if you are allergic to azithromycin, or if:

you have ever had jaundice or liver problems caused by taking Azifast; or you are allergic to similar drugs such as clarithromycin, erythromycin, or telithromycin.

To make sure Azifast is safe for you, tell your doctor if you have ever had:

liver disease; kidney disease; myasthenia gravis; a heart rhythm disorder; or low levels of potassium in your blood; or long QT syndrome (in you or a family member).

Azifast is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether azithromycin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Do not give Azifast to a child younger than 6 months old.

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