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Aviglen (Glibenclamide)
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Aviglen

Aviglen is in a drug class known as sulfonylureas. Sulfonylureas work by telling your pancreas to release insulin, which lowers your blood sugar. The usual starting dose of Aviglen as initial therapy is 2.5 to 5 mg by mouth once daily with breakfast or the first main meal.

Other names for this medication:
Aviglen, Benclamet, Betanase, Betrol, Bionil, Codica, Combidos, Comdiab, Daonil, Diabetrol, Duotrol, Dutrol, Euglucon, Eumet, Giclamide, Glibet, Glibson, Glifil, Glime, Glimsug, Glinil, Glucomin, Glucored, Glucosil, Glybovine, Glycurub, Glymep, Iscept, Metclam, Metica, Monomet, Pionorm, Sugnil, Sugnl, Sugronil, Symet, Triglycomet

Similar Products:
Duricef, Tenormin, Indocin, Mestinon, Mircette, Paxil, Qutace, Famotidine, Ribomin, Cycloreg, Closin,

Also known as: Glibenclamide

Description

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Dosage

Usual Adult Dose for Diabetes Type 2:

Standard Aviglen: -Initial dose: 2.5 mg to 5 mg orally once a day -Dose titration: Increase in increments of no more than 2.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 1.25 to 20 mg orally as a single dose or in divided doses -Maximum dose: 20 mg/day Micronized Aviglen: -Initial dose: 1.5 mg to 3 mg orally once a day -Dose titration: Increase in increments of no more than 1.5 mg at weekly intervals based upon blood glucose response -Maintenance dose: 0.75 to 12 mg orally as a single dose or in divided doses -Maximum dose: 12 mg/day Comments: -Administer with breakfast or the first main meal of the day -Lower initial doses may be used in patients who are sensitive to hypoglycemic drugs -Once a day therapy is generally satisfactory, however, some patients may have a more satisfactory response with twice-a-day dosing, especially those receiving higher doses. TRANSFER FROM OTHER HYPOGLYCEMIC THERAPY: -Oral Antidiabetic Therapy: No exact dosage relationships exists between standard Aviglen, micronized Aviglen, or other oral hypoglycemic agents; when transferring patients from other oral hypoglycemic therapy, the maximum starting doses should be observed. -Insulin: --If the insulin dose is less than 20 units per day substitute 2.5 to 5 mg (standard) OR 1.5 to 3 mg (micronized) orally once a day. --If the insulin dose is between 20 and 40 units per day, substitute 5 mg (standard) OR 3 mg (micronized) orally once a day. --If the insulin dose is more than 40 units per day; transition the patient by concomitantly decreasing insulin by 50% and starting Aviglen at 5 mg (standard) OR 3 mg (micronized) orally once a day; as insulin is progressively withdrawn, titrate in increments of 1.25 to 2.5 mg (standard) OR 0.75 to 1.5 mg (micronized) orally once a day every 2 to 10 days. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Usual Geriatric Dose for Diabetes Type 2:

Initial dose: 1.25 to 2.5 mg (standard) orally or 0.75 to 1.5 mg (micronized) orally once a day.

Detailed Aviglen dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A Aviglen overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Aviglen dosage information

Side effects

The most common side effects associated with Aviglen are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

It is very important to follow carefully any instructions from your health care team about:

  • Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team.
  • Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, patients with diabetes may need special counseling about diabetes medicine dosing changes that might occur because of lifestyle changes, such as changes in exercise and diet. Furthermore, counseling on contraception and pregnancy may be needed because of the problems that can occur in patients with diabetes during pregnancy.
  • Travel—Keep your recent prescription and your medical history with you. Be prepared for an emergency as you would normally. Make allowances for changing time zones and keep your meal times as close as possible to your usual meal times.
  • In case of emergency—There may be a time when you need emergency help for a problem caused by your diabetes. You need to be prepared for these emergencies. It is a good idea to wear a medical identification (ID) bracelet or neck chain at all times. Also, carry an ID card in your wallet or purse that says you have diabetes and a list of all of your medicines.
Check with your doctor right away if you start having chest pain or discomfort, nausea, pain or discomfort in the arms, jaw, back, or neck, shortness of breath, sweating, or vomiting while you are using this medicine. These may be symptoms of a serious heart problem, including a heart attack.

Too much Aviglen can cause low blood sugar (hypoglycemia) when it is used under certain conditions. Symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out). Different people may feel different symptoms of low blood sugar. It is important that you learn which symptoms of low blood sugar you usually have so that you can treat it quickly and call someone on your health care team right away when you need advice.

Symptoms of hypoglycemia (low blood sugar) include anxiety, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool, pale skin, difficulty in thinking, drowsiness, excessive hunger, fast heartbeat, headache (continuing), nausea, nervousness, nightmares, restless sleep, shakiness, slurred speech, or unusual tiredness or weakness.

If symptoms of low blood sugar occur, eat glucose tablets or gel, corn syrup, honey, or sugar cubes; or drink fruit juice, non-diet soft drink, or sugar dissolved in water. Also, check your blood for low blood sugar. Glucagon is used in emergency situations when severe symptoms such as seizures (convulsions) or unconsciousness occur. Have a glucagon kit available, along with a syringe or needle, and know how to use it. Members of your household also should know how to use it.

Do not take this medicine if you are also using bosentan (Tracleer). Also, make sure your doctor knows about all other medicines you are using for diabetes, including insulin.

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Mr 250 000 in the absence of mercaptoethanol and Mr 130 000 in its presence. Interrelationship between energy metabolism from various substrates and the 2,3-bisphosphoglycerate bypass in human erythrocytes. In asthmatic patients with EIB, a statistically significant increase in eotaxin concentrations in EBC collected during the first 24 h after an exercise test - with maximal increase after 6 h - was revealed. Five nonindigenous plant species were tested--barley (Hordeum vulgare), rye corn (Secale cereale), Italian ryegrass (Lolium multifiorum), red clover (Trifolium pratense), and lucerne (Medicago sativa)--in five different types of substrate: unamended tailings, tailings and fertilizer, tailings and greenwaste, biosolid-blend compost, and local topsoil. Binding of an indole derivative to micelles as quantified by phase-sensitive detection of fluorescence. It is also possible to measure the birth weight of the multiple babies exactly clinically. Oviposition behaviour of four ant parasitoids (Hymenoptera, Braconidae, Euphorinae, Neoneurini and Ichneumonidae, Hybrizontinae), with the description of three new European species.

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At least two mechanisms are considered to be involved in such learning. In two cases, rapid polymerization of bucrylate resulted in gluing of the injection catheters into the arterial lumen. These techniques also have applications in non-malignant disease, and the treatment of two patients with benign ureteric stricture is described. Indoor risk factors for allergic diseases in low-income households in Korea have been characterized only partially. Future research related to absenteeism, redeployment during actual pandemic events is urgently needed. Power scaling of a picosecond vortex laser based on a stressed Yb-doped fiber amplifier. In addition, mutant analysis and pharmacological treatments demonstrate that both initiation and maintenance of dbx1b expression requires precise regulation by fibroblast growth factor (FGF) signaling. Late presentation of HIV is common and is associated with several adverse outcomes including an increased risk of clinical progression, blunted immune recovery on highly active antiretroviral therapy and a greater risk of drug toxicity. Detecting white matter injury in sickle cell disease using voxel-based morphometry.

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Hereditary ring sideroblastic anaemia and Christmas disease in a Swedish family. If not accounted for in data collection or analyses, individual differences in non-financial barriers to medical care may read to an underestimation of the influences of important home environmental risk factors for medically attended injuries. We hypothesized that orthostatic intolerance (OI) is associated with gastric dysrhythmias, nausea, and abdominal pain, which improves using fludrocortisone to treat OI. The rheological behaviour of the wet powder masses was studied as a function of mixing time using a mixer torque rheometer (MTR). Fast-track surgery for gastroenteric neoplasms: a meta-analysis. Periodontitis is associated with preeclampsia in pregnant women. Reaction velocity-substrate concentration data were analyzed to obtain maximum reaction velocity (Vmax) and Michaelis-Menten constant (Km).

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The depressor responses (expressed as percent decrease in blood pressure as compared to its blood pressure value prior to aortic nerve stimulation) produced by these stimulations were significantly smaller in SHR than those in WKY. Short and long term outcomes associated with fetal cholelithiasis: a report of two cases with antenatal diagnosis and postnatal follow-up. Circadian variations in response to amphetamine and chlorpromazine in the rat. The potential impact of climate on human exposure to contaminants in the Arctic. We improved myosin gene models and found that myosin genes undergo alternative splicing. Localization of GABA-like immunoreactivity in the central nervous system of Aplysia californica. Streptozotocin-induced diabetes causes astrocyte death after ischemia and reperfusion injury.

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The effects of diet and cold on body composition and fat distribution in the white rat. A six-month-old boy with neonatal lupus and cardiac enlargement. Circulating DNA is a noninvasive marker, which may help to improve the prognostic profile of these patients. However, the recognition that these receptors may have distinct biologic functions suggests that additional signaling elements may contribute to functional diversity. Clinico-genetic characteristics of psychoses with a clinical picture of involutional melancholia. The purpose of this review is to summarize sex differences in the prevalence of hypertension and hyperlipidemia.

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Primary debulking surgery versus neoadjuvant chemotherapy in stage IV ovarian cancer. A marked increase (45-77 per cent) in CBZ plasma level was found in all patients on combined treatment of CBZ and PRX. Effect of ascorbic acid on copper-induced oxidative changes in erythrocytes of individuals with a glucose-6-phosphate dehydrogenase deficiency. To assess the relative contribution of intrinsic and extrinsic factors we compared multilevel analysis results obtained from subjects of Homo sapiens and Macaca mulatta, the latter kept in a controlled environment with a standardized diet by making use of previously published data and results. The association between murine cytomegalovirus induced hepatitis and the accumulation of oval cells.

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Specialized variants of the constitutive 20S proteasome in the immune system like the immunoproteasomes and the thymoproteasome contain active site-bearing subunits which differ in their cleavage priorities and substrate binding pockets. Investigations on the microbiology of cellulose utilization in domestic rabbits. Metastatic tumor of the epididymis protonix 60 mg from pancreatic carcinoma: a case report. In Japan, cytological examination is performed for uterine cervical cancer screening, but the rate of participation in these programs is low. We have used single stranded DNA (ssDNA) to direct the self-assembly process. TSC2 encodes tuberin, a protein with roles in cell growth and proliferation, transcriptional activation, and endocytosis. The adherence of cTnT or T-I-C complex to the dialyser membrane could not be demonstrated and supports the observation that pre-HD and post-HD serum concentrations of cTnT are similar. The available data indicate that magnetic fields can interact with biological material to produce effects, although the reported effects are usually small in magnitude and often unconfirmed. Unusual appearances of uterine leiomyomas: MR imaging findings and their histopathologic backgrounds.

glibenclamide 2019-05-21

The loaded push-ups and 2-mile run appear to remove M-bias and are probably more occupationally relevant as military personnel are often expected to carry external loads. Using the results of a survey on Board certification, the authors compared FMGs with U.S. This review aims to highlight the possible risks and benefits of L-carnitine supplementation. Two cases with vertically malpositioned incisors were treated using the MTD, and this device was evaluated and compared with the distraction appliances used before in the literature. Enhanced Th17-cell responses render CCR2-deficient mice more susceptible for autoimmune arthritis. Suture laterofixation of the vocal fold for bilateral vocal fold immobility. This protocol has been successfully used in rodents and an outbred large animal model. The described pressure measuring system allows measuring intraocular pressure continuously and assessing the individual effect of different antiglaucomatous drugs.

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