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Aristomycin (Roxithromycin)
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Aristomycin

Aristomycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. It is a white crystalline powder. Aristomycin is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring.

Other names for this medication:
Aristomycin, Asmetic, Assoral, Bazuctril, Biaxsig, Bicofen, Biostatik, Cadithro, Dorolid, Elrox, Erybros, Floxid, Infectoroxit, Klomicina, Makrodex, Monobac, Nirox, Odonticina, Pedilid, Pedrox, Ramivan, Redotrin, Renicin, Ritosin, Rokilide, Rokithrid, Rolexit, Rolicyn, Rolid, Romyk, Rossitrol, Rotramin, Roxacine, Roxithromycin, Roxithromycinum, Roxitromicina, Rulid

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Also known as: Roxithromycin

Description

Aristomycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Aristomycin is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Aristomycin is available under several brandnames. Aristomycin is not available in the United States. Aristomycin is available in Australia, Israel and New Zealand. Aristomycin has also been tested to possess antimalarial activity.

Aristomycin prevents bacteria from growing, by interfering with their protein synthesis. Aristomycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Aristomycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.

Dosage

Take Generic Aristomycin by mouth with food. If you have trouble swallowing the tablet whole, it may be crushed or chewed with a little water. Swallow Generic Aristomycin tablets whole with a glass of water. Generic Aristomycin should be taken at least 15 minutes before food or on an empty stomach (i.e. more than 3 hours after a meal). Generic Aristomycin works best if you take it on an empty stomach. For treating bacterial infections, Generic Aristomycin is usually taken for 5 to 10 days. If you want to achieve most effective results do not stop taking Generic Aristomycin suddenly.

Overdose

Symptomatic treatment should be provided as required. There is no specific antidote.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep out of the reach of children.

Side effects

The most common side effects associated with Aristomycin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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Childhood chest illness and the rate of decline of adult lung function between ages 35 and 45 years. Some epidemiologic factors that are associated with CKD (obesity and diabetes) are increasing, whereas others (uncontrolled hypertension and smoking) are decreasing. Furthermore, the coefficient needed to adjust dV/dt to reconstructed Ii may serve as an indicator of the membrane capacity. In patients-residents of low- and middle-mountain regions the severity of clinical and hemodynamic disorders depended on the stage of cardiac insufficiency, whereby in residents of the second region the disclosed deviations on the level of circulation proved more marked. Patency and complication rate of 23 consecutive HDP with BMVG for VA were compared to a control group consisting of 23 similar HDP with ePTFE grafts. We classified 197 cases of urgent cesarean section performed at our institution between April 1st, 2010 and March 31, 2011, using the NICE classification. The specific binding of 11C-JHU75528 in vivo was blocked by preinjection of nonlabeled JHU75528.

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