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Arava

Arava is in a class of medications called disease-modifying antirheumatic drugs (DMARDs). It works by decreasing inflammation and slowing the progress of the condition, which can help improve the physical activity of people with rheumatoid arthritis.

Other names for this medication:
Cleft, Feluno, Leflunomide, Lefno, Lefra, Lefuma, Lefumide, Lisifen, Rumalef

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Also known as: Leflunomide

Description

Arava (leflunomide) affects the immune system and reduces swelling and inflammation in the body.

Arava is used to treat the symptoms of rheumatoid arthritis.

Dosage

Usual Adult Dose for Rheumatoid Arthritis:

Loading dose: 100 mg orally once a day for 3 days Maintenance: 20 mg orally once a day (If not well tolerated, the dose may be decreased to 10 mg orally once a day) Comment: -Hematology parameters and liver enzymes should be monitored. Use: For the treatment of active rheumatoid arthritis (RA): -To reduce signs and symptoms -To inhibit structural damage as evidenced by X-ray erosions and joint space narrowing -To improve physical function

Detailed Arava dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include diarrhea, stomach pain, pale skin, easy bruising or bleeding, dark urine, or jaundice (yellowing of the skin or eyes).

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Arava are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Arava if you are allergic to leflunomide or teriflunomide, or if:

you are pregnant (you will need to have a negative pregnancy test before starting this treatment); you have severe liver disease; or you are also using teriflunomide.

Do not use Arava if you are pregnant or may become pregnant. Avoid getting pregnant until after you stop taking Arava and undergo a "drug elimination" procedure to help rid your body of this medicine. Stop taking Arava and call your doctor right away if you miss a period or think you might be pregnant.

To make sure this medicine is safe for you, tell your doctor if you have:

a history of liver disease or hepatitis (leflunomide can cause severe liver problems); a severe or uncontrolled infection; kidney disease; nerve problems, such as neuropathy caused by diabetes; a history of tuberculosis; a weak immune system or bone marrow disorder; or if you are using any drugs that weaken your immune system (such as cancer medicine or steroids).

Use birth control to prevent pregnancy while you are taking this medicine. After you stop taking Arava, continue using birth control until you have received blood tests to make sure the drug has been eliminated from your body.

Ask your doctor if you should use a barrier form of birth control (condom or diaphragm with spermicide). Using hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may increase your risk of liver damage while taking Arava.

It is not known whether leflunomide passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

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