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Alertec (Modafinil)
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Alertec

Alertec is used to treat excessive sleepiness caused by narcolepsy or shift work sleep disorder (sleepiness during scheduled waking hours and difficulty falling asleep or staying asleep during scheduled sleeping hours.

Other names for this medication:
Alertec, Carim, Dekast, Modafinil, Modafinilo, Modalert, Modapro, Modatec, Modavigil, Modfil, Modiodal, Provake, Renea, Vigia

Similar Products:
Trandate, Xalatan, Catapres, Zantac, Pamelor, Depakote, Aldara, Elocon, Quzine, Clonzy, Saczine, Amven, Jotair, Deprid, Mustopic, Closis, Pifert, Pacyl,

Also known as: Modafinil

Description

How Alertec works to help increase wakefulness and decrease sleepiness isn’t clear. The drug works in the brain to increase amounts of certain chemical messengers such as dopamine. It also seems to affect the messenger glutamate in certain areas of the brain.

These actions may result in stimulation of brain activities, which could make you feel less tired.

How long does it take to work?

Alertec begins to work within 30 to 60 minutes of when you take it. If you take it with food, the drug might take slightly longer to start working.

Dosage

Usual Adult Dose for Narcolepsy:

200 mg orally daily in the morning

Usual Adult Dose for Obstructive Sleep Apnea/Hypopnea Syndrome:

200 mg orally daily in the morning

Usual Adult Dose for Shift Work Sleep Disorder:

200 mg orally daily one hour prior to the start of the work shift

Usual Pediatric Dose for Attention Deficit Disorder:

Not FDA approved. Reports of serious dermatologic adverse effects and psychiatric events has resulted in the FDA's Pediatric Advisory Committee unanimously recommending that a specific warning against the use of modafinil in children be added to the manufacturer's labeling; use only if first- and second-line treatments have failed and the benefits outweigh the risks. Children less than 30 kg: 200-340 mg once daily Children more than 30 kg: 300-425 mg Randomized, double-blind, placebo-controlled pediatric studies have utilized an 85 mg film-coated tablet (currently not commercially available) to provide these dosages. All studies utilized a titration method but varied the length of titration (3 weeks vs 7-9 days); clinical improvement was noted earlier in the shorter titration period.

Detailed Alertec dosage information

Overdose

If you overdose Alertec and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Alertec are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Alertec if you have ever had an allergic reaction or skin rash while taking modafinil or armodafinil (Nuvigil).

To make sure Alertec is safe for you, tell your doctor if you have:

angina (chest pain); cirrhosis or other liver problem; kidney disease; high blood pressure, heart disease, or history of heart attack; a history of mental illness or psychosis; or history of alcoholism or drug addiction.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Alertec can make certain birth control less effective. Hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment. Talk with your doctor about the best methods of birth control to use while taking Alertec.

It is not known whether modafinil passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Alertec is not approved for use by anyone younger than 17 years old.

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Effect of lead exposure and accumulation on copper homeostasis in cultured C6 rat glioma cells. Clinical trial with Mebendazole (R-17,635) in the treatment of intestinal helminthiasis. We find that a continuous system (i.e., no stacking gel) with a gradient in its extent of cross-linking and use of the clear native buffer system performs well for both fractionation and native mass spectrometry of heart extracts and a fungal secretome. Axial rotations along the transverse, coronal, and frontal planes were measured as half-cycles (i.e., left-right or flexion-extension) that were repeated seven times per trial. To evaluate this interesting spatial problem, we studied the ultrastructural distribution of chromatin in distinct stages of apoptosis using the microglial cell-line, BV-2, as a model and UV irradiation as a trigger of apoptosis. X-ray diffraction (XRD) and scanning electron microscopy (SEM) were used to characterize these thermoelectric nanofibers.

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Immunogenicity and protective efficacy of a human immunodeficiency virus type 2 recombinant canarypox (ALVAC) vaccine candidate in cynomolgus monkeys. The first derivative of left ventricular (LV) pressure over time (dP/dt max) is a marker of LV systolic function that can be assessed during cardiac catheterization and echocardiography. Both are randomized controlled studies, exclusively focused on female patients. Their dietary consumption is associated with numerous health benefits. The knee joint space size of the patients increase regularly with increasing height up to 180 cm. Export of a single drug molecule in two transport cycles by a multidrug efflux pump. Interaction between pathogenic bacteria and intrauterine leukocytes triggers alternative molecular signaling cascades leading to labor in women.

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Taken together, these data suggest that the relative generation times of hosts and parasites may not be an important determinant of local adaptation in this system. Intracellular levels of Ca, Na, K, and Mg during the ouabain response and the dependence of the response on extracellular Ca. Growth-blocking peptide (GBP) is an insect cytokine that stimulates a class of immune cells called plasmatocytes to adhere to one another and to foreign surfaces. The presence of multiple conformers of SL-AP-B and its tendency to aggregate render it unsuitable for high-resolution NMR structural studies of the isolated ligand, but the retention of activity may make it useful for studies of the sodium-channel-bound form of the molecule. In spite of this, the histogenesis of RMC in the presented cases in the end remains uncertain. Some available research on food and cooking practices in the current context is presented, with a focus on how these are affecting health and how they might be contributing to health inequalities within the population. A phase response curve for masking was obtained by placing hamsters in novel wheels for 3-h periods at various times throughout their circadian cycles, and then superimposing a 30-min light pulse. Core-shell amylopectin-coated cellulose nanofibers and nanocomposites are prepared to investigate effects from the distribution of AP matrix.

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A case of unruptured aneurysm of the right sinus of valsalva with right ventricular outflow obstruction. Therefore, by combining different techniques, our results indicate that carboxyl functional groups are the major ligands responsible for the metal binding in P. Electrical field stimulation of endothelin-1-contracted preparations produced frequency-dependent responses: a contractile twitch followed by a fast relaxant response. Family history of ovarian/breast cancer was associated to the risk of all ovarian cancer types, except mucinous ones. ABO incompatibility is now the most common cause of isoimmune hemolytic disease of the newborn here. Thin-section multi-detector row computed tomographic (CT) colonography is a powerful tool for the detection and classification of colonic lesions. IL-1ra production was evident 4 hours after stimulation with IgG-coated red cells and increased progressively over 24 hours. Time necessary to decelerate from an internal rotation perturbation. We propose that the pressure sensor enables evaluation of the tongue position, but further investigation is required. The gland was therefore placed in a subcutaneous position in the lowest part of the operative field just above the sternal border.

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Importantly, such differences also emerged in superior temporal key regions. Twelve patients with psoriasis vulgaris who presented with psoriatic lesions in the axilla, and inguinal and anal folds, were treated with calcipotriol ointment (50 micrograms/g) twice daily for 6 weeks. Polymerase chain reaction (PCR) products were synthesized for four house-keeping genes, cyclophilin, beta-actin, hypoxanthine phosphoribosyltransferase (HPRT) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and the following cytokines: interleukin (IL)-1beta, IL-4, IL-6, IL-8, IL-10, IL-12 p35, IL-12 p40, IL-18, interferon (IFN)-alpha, IFN-beta, IFN-gamma, tumour necrosis factor (TNF)-alpha, macrophage inhibition factor (MIF) and granulocyte/macrophage colony-stimulating factor (GM-CSF). Combined use of alveolar distraction osteogenesis and segmental osteotomy in anterior vertical ridge augmentation. Here we show that a cortical aPKC loading induces Lgl cytoplasmic release and massive overgrowth in Drosophila imaginal epithelia, whereas a cytoplasmic expression does not alter proliferation and epithelial overall structure. To determine whether three Aedes mosquito species have similar plasticity in SSD, attain sexual dimorphism through similar strategies, and whether SSD and SBM are associated. Isothiocyanates have been shown to inhibit carcinogen-induced tumorigenesis in animal models, yet no efforts have been made to determine their therapeutic potential in OC.

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Hemodynamic shear stress stimulates a number of intracellular events that both regulate vessel structure and influence development of vascular pathologies. All the cultures were negative and there was not evidence of clinical infection in the year following the study. Immunohistochemically, carcinoma cells were positive for cytokeratins, epithelial membrane antigen and CA 19-9 and negative for vimentin, while sarcomatous cells were positive for vimentin and negative for cytokeratins, epithelial membrane antigen and CA 19-9. However, centromere cohesion was maintained before anaphase in Rad21-depleted cells, and the primary constrictions at centromeres were indistinguishable from those in control cells. Determination of delta-antibody binding to intact cell monolayers supported the finding that the two cell lines demonstrate equivalent plasma membrane GT content. The result based on the PCR assay was identical to the results of amplification of the Y chromosome-specific SRY gene and those of investigations of the phenotypic gender in three different horse populations. A radioimmunoassay for the determination of tipredane in human plasma.

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Mini-screw fixation for the treatment of proximal interphalangeal joint dorsal fracture-dislocations. The ara gene is amplified in the MDR leukaemia line CCRF-CEM/E1000 and its mRNA is overexpressed. The purpose of this study was to determine the agreement between angular measures of cervical spinal motion obtained from radiographs and from measures recorded by the OSI CA 6000 Spine Motion Analyzer (OSI SMA) in asymptomatic subjects. Natural alternatives to tackling high cholesterol: guidance for community nurses. Furthermore, some have questioned the nature of the relationship: most research suggests that psychological factors mediate the relationship between socioeconomic status and health, but recent research suggests that they moderate the relationship. Differing effects of estradiol on erythroid cells in the bone marrow and spleen of guinea pigs. Release of ATP from perfused heart during coronary vasodilatation. Although the ubiquitin-proteasome pathway is upregulated in septic muscle, it is still unclear how the myofibrillar proteins actin and myosin are ubiquitinated and become substrates for the 26S proteasome. The unexpected influence of the aryl substituent in N-aryl-3-oxobutanamides on the behavior of the reaction was discovered.

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Fluoride release/uptake of polyacid-modified resin composites (compomers) in neutral and acidic buffer solutions. Remote reperfusion lung injury occurs in patients with vascular occlusion and surgical procedures. The study group consisted of 150 healthy individuals without any psychiatric disorder and 300 patients with an anxiety disorder and/or major depressive disorder according to DSM-IV criteria. These results support current recommendations on the duration of breastfeeding in an ethnic group at risk for asthma. Industrial accidents and compensation from an industrial health viewpoint. Because of its simplicity and ease, the procedure is applicable as a screening method for patients with abnormal uterine bleeding or questionable hysterograms and for patients with suspected intrauterine pathology.

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Living donor liver transplantation has recently been reported for adults and children with acute liver failure. Riluzole- and Resveratrol-Induced Delay of Retinal Ganglion Cell Death in an Experimental Model of Glaucoma. The independent prognostic ability of clinical markers was evaluated using the Cox proportional hazard model. Moreover, the possibility of developing vaccines using attenuated viruses with deletions in nef and other crucial genes raises the possibility that the AIDS epidemic might one day be restrained. The serum concentration of 1,25-dihydroxyvitamin D was depressed in untreated diabetic rats to one-eighth of the level in controls and was restored to control levels by insulin treatment. In skeletal muscles, blood volume changes are caused by the temperature-dependent regulation of the vessel diameter (vasodilatation).

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Computer assisted detection software for CT colonography: effect of sphericity filter on performance characteristics for patients with and without fecal tagging. Is the present therapy for coronary artery disease the radical mastectomy of the twenty-first century?. During the in vivo pituitary surgery, EPS with image guidance can provide accurate and reliable stereoinformation to achieve better results with lesser risks, particularly in complex cases or in reoperations, even in the hands of experienced surgeons. The histopathological observations of the present study support the hypothesis that the blood vessels, and the endothelial cells in particular, are the critical target population responsible for the lesions seen in the spinal cord after BNCT type irradiation and by inference, after more conventional irradiation modalities such as photons or fast neutrons. Circulating concentrations of heme oxygenase-1 (HO-1) have been recently reported to be elevated in several chronic disorders. The mass was resected and histological examination revealed an ectopic pancreas.

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