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Alendronate slows calcium loss from bones. It helps to make normal healthy bone and to slow bone loss in people with Paget's disease and osteoporosis. It may be used in others at risk for bone loss. It is more popular than comparable drugs. It is available in generic and brand versions.

Other names for this medication:
Alant, Alendix, Alendronate, Alenost, Bifosa, Denfos, Osteofos, Ostogee, Poronil, Ralenost, Restofos, Zophost

Similar Products:
Luvox, Arcoxia, Sildigra, Eriacta, Vantin, Cleocin, Calan, Obimet, Prosed, Newpen, Pantorox,


Alendronate Plus D contains a combination of alendronate and cholecalciferol. Alendronate is a bisphosphonate medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures.

Cholecalciferol is a form of vitamin D, and is important for the absorption of calcium from the stomach and for the functioning of calcium in the body.

Alendronate Plus D is used to treat and prevent osteoporosis.


Take Alendronate exactly as prescribed by your doctor. Alendronate is taken either once daily or once per week. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take Alendronate first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine. If you take this medicine only once per week, take it on the same day each week and always first thing in the morning.

Take with a full glass (6 to 8 ounces) of plain water. Do not use coffee, tea, soda, juice, or mineral water. Do not eat or drink anything other than plain water.

Do not crush, chew, or suck on an Alendronate tablet. Swallow the tablet whole.

For at least 30 minutes after taking Alendronate:

Do not lie down or recline. Do not take any other medicine including vitamins, calcium, or antacids.

Pay special attention to your dental hygiene while taking Alendronate. Brush and floss your teeth regularly. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using alendronate.

Alendronate is only part of a complete program of treatment that may also include diet changes, exercise, bone mineral density testing, and taking calcium and vitamin supplements. Follow your doctor's instructions very closely.

Store at room temperature away from moisture and heat.

Your doctor will determine how long to treat you with this medicine. Alendronate is often given for only 3 to 5 years.

Detailed Alendronate dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Drink a full glass of milk and call your local poison control center or emergency room right away. Do not make yourself vomit and do not lie down.

Overdose symptoms may include muscle cramps, numbness or tingling, tight muscles in your face, seizure (convulsions), irritability, and unusual thoughts or behavior.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alendronate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Avoid taking any other medicines for at least 30 minutes after taking Alendronate. This includes vitamins, calcium, and antacids. Some medicines can make it harder for your body to absorb alendronate.

Avoid smoking, or try to quit. Smoking can reduce your bone mineral density, making fractures more likely.

Avoid drinking large amounts of alcohol. Heavy drinking can also cause bone loss.

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An azaphilonidal derivative monaphilone A (MA) was recently isolated from the fermented products of Monascus purpureus NTU 568 by our laboratory. Mutational analysis and NMR spectroscopy of quail cysteine and glycine-rich protein CRP2 reveal an intrinsic segmental flexibility of LIM domains. Morphological changes in the aorta of rabbits with chronic renal failure. Cross-sectional studies were not formally included but we describe their findings and use them to generate hypotheses to inform future research. Infrared diode laser spectroscopy of the Ne-D2O van der Waals complex: strong Coriolis and angular-radial coupling. The fold difference in diffusion coefficients between the macrocyclic and linear analogues appeared to be independent of either solvent viscosity or dielectric environment.

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Influence of fasting period, ligation time, sex, age and bodyweight on the gastric secretory response of pylorus-ligated Wistar rats. Intracranial subependymomas are rarely reported due to their extremely low incidence. Digital subtraction angiography demonstrated a high-grade stenosis of the left vertebral artery origin with a thrombus just distal to the stenosis. However, there are few reports about endovascular therapy for intracranial embolic infarction from VAD. Furthermore, timely periodontal treatment, in some cases including periodontal surgery supplemented by the use of antibiotics, is warranted. There were, however, no significant interspecific differences in auditory sensitivity for stimuli between 200 and 700 Hz. Four children were hospitalized and spent in a hospital 1 to 2 weeks, in remaining patients, the disease was mild. The greatest discrepancy was exhibited by AMP which exerted a protective effect on human lymphocytes, but increased enzyme efflux from rat lymphocytes. The promotion of practical guidelines, point-of-care risk assessment tools, tailored educational tools, and other systems-level strategies will assist primary-care providers in providing genetics services for their patients.

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Whole gut lavage with a polyethylene glycol electrolyte solution (PEG) is a common bowel cleansing method for diagnostic and therapeutic colon interventions. Simple phenols content of I-1 strain was increased significantly, but that of R-1 strain had no significant change. In this paper, we consider online support vector machine (SVM) classification learning algorithms with uniformly ergodic Markov chain (u.e.M.c.) samples. The results of the present study for acutely altitude-exposed rats are opposite to those of a previous study for chronically altitude-exposed rats in which BVI, TBV, and the ability for arterial BP regulation were increased. The most prominent examples are probably the human immunodeficiency viruses HIV-1 and HIV-2.

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Open thyroid biopsies from seven patients of bacilliferous leprosy were studied for leprous granuloma or amyloid deposition. Time-course analysis of IFN-gamma-induced alterations in ZO-1 expression and apical actin perturbation indicated that these two effects were intimately linked and could not be dissociated. The positions and spectral shapes of the main exciton components in this model are determined by the disorder-induced shift of exciton eigenvalues in combination with phonon-induced effects (i.e., reorganization shift and broadening, that increase in proportion to the inverse delocalization length of the exciton state). Nonmicrosurgical replantation using a subcutaneous pocket for salvage of the amputated fingertip. Mapping the interaction between murine IgA and murine secretory component carrying epitope substitutions reveals a role of domains II and III in covalent binding to IgA. Effect of afferent vagal stimulation on the electroencephalogram of the cat in cerebral isolation. This disease is more prevalent in males and is frequently associated with allergies. However, Sox9 does not appear to be able to induce the chondrocyte phenotype in nonchondrogenic cells, implying that other factors are involved in chondrogenesis. Key roles for freshwater Actinobacteria revealed by deep metagenomic sequencing.

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Assessment of 102 consecutive patients (65 females), with a mean age of 82 years (range 35-98) without specific inclusion or exclusion criteria. Methods for the attachment of haptens and proteins to erythrocytes. Hierarchical regression analyses were used to determine the predictive utility of Stressful Life Events Questionnaire and Post-Traumatic Stress Disorder Checklist after controlling for age, injury severity (complicated versus uncomplicated mild) and preinjury depression. A sustiva 600 mg low protein diet alters bone material level properties and the response to in vitro repeated mechanical loading. Culturing marine bacteria - an essential prerequisite for biodiscovery.

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Amount and distribution of solid and fatty tissues in the female breast and their relationship to carcinoma. The goals of this study were to (1) identify valid variables that correlate with emergency department (ED) crowding and (2) determine a model that could be used to accurately reflect the degree of ED crowding. Surgical treatment of ruptured abdominal glucophage medication classification aortic aneurysms in the elderly. The currently used empirical relationship between ARTI and incidence can be used by programme managers as an effective monitoring tool. Although emergency surgery was planned, the patient died of rupture of the aneurysm with cardiogenic shock and sudden pericardial tamponade. In contrast, the stem cell model of carcinogenesis emphasizes the role of stem cells as the initiating structure for tumor development. Antibiotic susceptibilities were determined using broth microdilution MIC methodology according to the CLSI recommended with standard and 100-fold-higher inocula.

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Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237. Significantly, this lack of methylation appears to be specific to the expanded FMR1 CGG-repeat region, because various linked and unlinked repetitive-element loci are methylated normally. Initially, these injuries are routinely evaluated with radiographs, followed by magnetic resonance imaging (MRI). Post-processing of images and spot counting is briefly discussed to demonstrate the capabilities of this method for the statistical analysis of RNA molecule number per cell, which is information that can be utilized to determine overall gene expression levels and cell-to-cell gene expression variation. Ischemia is often a contributing factor in the diabetic foot ulcer that must be recognized and treated to avoid prolonged hospitalization, spreading infection, and unnecessary amputation. We conclude that pertussis is a prevalent disease in Taiwan, especially in adolescents and adults. By integrating gold-etched microheaters with the micropost design in a microfluidic device, we investigate the localized temperature effect on both the precursor and FISP, with complementary investigations from SANS. We tested the predictions that condition dependence should be more pronounced in male sexual traits and that genetic variance in expression of these traits should increase under stress as among-genotype variation in overall condition is exposed. The Primary Care Pharmacy Specialty Network (PC-PSN) was established in 2007 to support collaboration among pharmacists working in primary care. In conclusion, the pigment Nissl sumycin dose stain shows that the lateral central nucleus of the human amygdala has three subnuclei, and the accessory islands are part of two of these subnuclei.

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The paroxysmal dyskinesias are a subset of the hyperkinetic movement disorders characterized by their episodic nature. Trilateral retinoblastoma with an RB1 deletion inherited from a carrier mother: a case report. Collectively these results suggest that the transcellular defect in Notch signaling attributed to residue K613 in cytoplasmic tail of Dll1 may result from altering its multi-ubiquitination and increasing its retention in lipid rafts. Mortality and complications of hip fracture in young adults: a nationwide population-based cohort study. Additional research is needed to investigate the long-term, earthquake-related psychopathology. Alternative reimbursement approaches for hearing aids, eyeglasses and laboratory services. On the basis of the results of this investigation, the authors suggested that SLA technology was superior for the fabrication of dental casts. The mathematical model ensures that all the constraints of the PSF are satisfied, and the maximum-likelihood approach ensures that the specimen is nonnegative. Even more, we show that this implies that non-Kolmogorovian probability is needed for its study, and provide a set of new partial differential equations for groundwater flow. Individual cells transmit aristocort cream generic through multiple terminals varying in size, but smaller terminals generate faster and larger calcium transients to trigger vesicle release with higher initial gain, followed by more profound adaptation.

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