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Afdiex (Glibenclamide)

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Afdiex is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes. Afdiex is in a class of medications called sulfonylureas.

Other names for this medication:
Benclamet, Betrol, Codica, Combidos, Daonil, Diabetnil, Diabetrol, Diabnil, Euglucon, Eumet, Giclamide, Glibact, Glifil, Glimsug, Glinil, Glitrac, Glucored, Glucosafe, Glybenclamide, Glybid, Glycurb, Glycurub, Glymep, Iscept, Melitus, Secrin, Sugnil, Sugnl, Sugronil, Sycored, Symet, Triglycomet

Similar Products:
Panadol, Cipro, Trandate, Daklinza, Zetia, Symmetrel, Albenza, Benemid, Adglin, Metronex, Sterdu, Serophene, Trazol, Clopivas, Edcin, Bromocriptine, Sumet,

Also known as: Glibenclamide


This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.


Usual Adult Dose for Diabetes Type 2:

Doses provided as Afdiex-metformin -As Initial Therapy in Patients with Inadequate Glycemic Control on Diet and Exercise Alone: Starting dose: 1.25 mg-250 mg orally once a day -Consider a starting dose of 1.25 mg-250 mg orally twice a day for patients with fasting blood glucose (FBG) greater than 200 mg/dL or HbA1c greater than 9% Maintenance Dose: Increase in increments of 1.25 mg-250 mg per day every 2 weeks up to the minimum effective dose to achieve glycemic control Maximum Initial Dose: 10 mg-2000 mg per day -Patients with Inadequate Glycemic Control on a Afdiex (or another Sulfonylurea) and/or Metformin: Initial dose: 2.5 mg-500 mg or 5 mg-500 mg orally twice a day Maintenance Dose: Increase in increments of no more than 5 mg-500 mg to the minimum effective dose to achieve adequate blood glucose control Maximum Dose: 20 mg-2000 mg per day Comments: -Give with meals; 5 mg-500 mg dose should not be used as initial therapy due to an increased risk of hypoglycemia; initial doses should be conservative to avoid hypoglycemia largely due to Afdiex and gastrointestinal side effects largely due to metformin. -For patients who are switching to combination therapy, initial doses should not exceed the daily dose of Afdiex (or equivalent sulfonylurea) and metformin already being taken; the decision to switch to the nearest equivalent dose should be based on clinical judgement. -Addition of thiazolidinedione may be appropriate for patients not adequately controlled on Afdiex-metformin; in patients experiencing hypoglycemia, consider reducing the dose of the Afdiex component. -Monitor patients closely for signs and symptoms of hypoglycemia. Use: As an adjunct to diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus.

Detailed Afdiex/metformin dosage information


In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include hypoglycemia symptoms as well as the following:

  • seizures
  • loss of consciousness


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Side effects

The most common side effects associated with Afdiex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

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Could tofacitinib, the first oral small-molecule inhibitor proven for use in active rheumatoid arthritis (RA) patients with insufficient response to methotrexate, be the breakthrough drug for RA?. There was no obvious effect in the liver of female fish, suggesting that the hepatic toxicity of BPAF is gender dependent. Altered levels of KP-metabolites have been observed in neuropsychiatric and neurodegenerative disorders as well as in patients with affective disorders. The internalization of posterior subcapsular cataracts (PSCs) in Royal College of Surgeons (RCS) rats. Re-examining premature mortality in anorexia nervosa: a meta-analysis redux. Preliminary results from the new guidelines indicate an improvement on previous practice, but also an ongoing need to monitor concentrations. IC on: Laparoscopic peritoneal dialysis catheter insertion using nitrous oxide under procedural sedation. Faster treadmill walking facilitates a more normal walking pattern after stroke, without concomitant increases in common gait compensations, such as circumduction.

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These bacterial shifts were also convergent with biogas production-it decreased in the beginning of the thermophilic phase with the bacterial biodiversity decrease and increased when the community seemed to be restored. Diagnostic laparoscopy under dual antiplatelet therapy with clopidogrel and aspirin. Reducing stroke in women with risk factor management: blood pressure and cholesterol. Variations of the location of the greater palatine foramina in dry human skulls. Although CTC play a pivotal role in the metastatic cascade and their prognostic impact has been repeatedly demonstrated, little is known about their escape mechanisms to immune system of the host. Differential diagnosis and treatment of excess gingival display. Weight perception may contribute to these differences if blacks are more likely to underestimate their weight. By oral contamination of mice with quite high doses of either an exogenous or an endogenous biotype of an Enterobacteriaceae species at day 4 after irradiation, it was attempted to induced such condition of intestinal overgrowth. A review of thromboangiitis obliterans in Negroes, with a report of one case in a male. To analyze the characteristics of double inversion recovery (DIR) turbo field echo (TFE) and turbo spin echo (TSE) sequences and explore the value of double inversion recovery TFE sequence on carotid artery wall imaging.

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Falciparum malaria in young children of rural Burkina Faso: comparison of survey data in 1999 with 2009. A large impacted bezoar was seen in the sigmoid colon, which was completely obstructed, and it was successfully removed by using colonoscopy. Role of refraction in the etiopathogenesis of unilateral amblyopia in orthotropia and microtropia. Early isolated paraspinal EMG abnormalities in occult carcinoma with spinal metastases. The effect of fluorescein on the accuracy of blood glucose determination by glucose meters.

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The butanol extract of Paulownia tomentosa stem showed antibacterial activity against Staphylococcus aureus (SG511, 285 and 503), Streptococcus pyogenes (A308 and A77) and Streptococcus faecium MD8b etc. Fractions in the molecular mass range, that were previously found to possess antigenic properties, were tested in a spermatozoa radio-receptor binding assay. All three measures showed sufficient reliability, validity and responsiveness in preschoolers with ID, but the PDMS-2 is recommended for its superior psychometric properties. Higher WSSG was found surrounding the growing region, and extremely low WSS was found at the growing region of the growing cerebral aneurysm. This study aimed to determine the correlation between resistin levels in patients with intra-abdominal sepsis and mortality. We found that CNV was widespread in our global sample, with a significantly higher occurrence in multigene families, especially in Ors. A total of 116 isolates representative of the 116 PFGE profiles were analyzed by multilocus variable-number tandem-repeat analysis (MLVA).

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Changes in the cervical spine of children with juvenile idiopathic arthritis evaluated with lateral cephalometric radiographs: a case control study. Unlike BMP-2, bFGF at 2-50 ng/mL was capable of enhancing long-term cell viability. Drivers in crashes who were intoxicated or fatigued were less likely to be wearing a safety belt and more likely to have contributed to the crash and experience serious injury or death. Particular issues in discussion are: etiological, clinical, diagnostic and therapeutic ones, that this rare condition posed in practical care. The diffuse form of supravalvular aortic stenosis may extend in the takeoff of the coronary and arch arteries. In vitro ubiquitination assay showed GmARI1 protein has E3 ligase activity. Experiments on the reduced effect of penicillin in individuals who were given preliminary penicillin therapy. The pathophysiologic mechanism, natural history, and optimal treatment of this disease are matters of debate.

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Tumor markers in peripheral blood of patients with malignant melanoma: multimarker RT-PCR versus a luminoimmunometric assay for S-100. Furthermore, LRRK1 serves as a scaffold facilitating the interaction of EGFR with the endosomal sorting complex required for transport-0 complex, thus enabling efficient sorting of EGFR to the inner vesicles of multivesicular bodies. Luciferase reporter assay confirmed the dependence of Myc-mediated DLEU2 transcriptional repression on HDAC3. The psychoanalytic process and analytic inference: a clinical study of a lie and loss. Coupling factor slow recovery (cfs) is a recessive mutant of Arabidopsis with anomalous ATP synthase activation/deactivation characteristics as well as a distinct growth phenotype. These cells have axons projecting into the contralateral nervus corporis allati (NCA) II, bypassing the corpus allatum and projecting through the NCA I into the storage part of the corpus cardiacum. Themes, doctrine, and pedagogy in the 2013-2014 National Health Law Moot Court Competition problem. Young adults with RA may develop periodontal destruction, and these patients require professional attention. ryanae isolates from Nepal, in addition to some sequence heterogeneity among different copies of the gene. Variable bright-darkfield contrast (VBDC) is a new technique in light microscopy which promises significant improvements in imaging of transparent colorless specimens especially when characterized by a high regional thickness and a complex three-dimensional architecture.

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The results of this study should underpin future governmental policy decisions regarding universal or selective vaccination against hepatitis B. The data presented in this paper show that the latter defect is associated with a decrease in the relative number of secondary ovarian follicles and an increase in the number of atretic follicles. Cross-sectional seroepidemiological study on serum samples collected in communities in two relatively developed provinces in west Anatolia with an official low prevalence of brucellosis and in one province in southeast Anatolia with a high prevalence. Concussion in professional football: recovery of NFL and high school athletes assessed by computerized neuropsychological testing--Part 12. Concerning the choice between salpingostomy and salpingectomy, it depends of the controlateral tubal patency. Building on these findings, we sought to determine whether proBNP1-108 processed forms in normal circulation are biologically active and stimulate cGMP, and whether proBNP1-108 processing and activity are altered in human heart failure (HF) compared with normal. Further studies are needed to determine the safety and efficacy of human chorionic gonadotropin as a potential therapy for preterm labor inhibition in human pregnancy. Panhypopituitarism secondary to a macroprolactinoma manifesting with pancytopenia: case report and literature review. In the unstimulated neoplasm the concentration of macrophages in the stroma was similar to that of normal connective tissue.

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The prevalence of diabetes mellitus increases with age and causes significant morbidity and poor quality of life in older adults. Imputation with zero needs considerably less training data, it shows only slightly worse results and simplifies the computation by maintaining the binary structure of the data. Associations between factors and treatment group were assessed by means of the Wilcoxon rank sum test for continuous variables and the Fisher exact test for categorical variables. Worries surrounding the first ultrasound do not bias the screening for depressive albenza dose and anxiety symptoms during pregnancy. Double umbilical cord blood transplantation: relevance of persistent mixed-unit chimerism. In isotopically labeled macromolecules, it is possible to excite the signal of a selected proton by shuttling magnetization back and forth between the chosen proton and a heteronucleus such as 13C or 15N, using two-way doubly selective heteronuclear cross-polarization. The application of TRP avoided any error in most of the patients. Pseudoaneurysm of uterine artery: a rare cause of secondary postpartum hemorrhage, managed with uterine artery embolisation. However, at later timepoints, declines in Mcl-1 can be reversed with effective caspase inhibition, suggesting that Mcl-1 is both an upstream regulator and a downstream target of caspase activity in human neutrophils. STAT3 is a pleiotropic transcription factor that is activated by the phosphorylation of tyrosine 705 in response to many cytokines and growth factors.

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Changes in vasotec class drug human amniotic fluid lecithin/sphingomyelin ratio and dipalmitoyl lecithin associated with maternal betamethasone therapy. No in-vitro studies, animal models, reports of adverse effects or clinical studies provide any convincing evidence of a disulfiram-like interaction between ethanol and metronidazole. Both in normal subjects and in RA patients who did not remain in bed throughout the period of blood sampling, levels of HA, Ag KS, and MMP-3 increased significantly during the first hour after the subjects arose: the increase in HA and Ag KS correlated with the Lansbury index in the RA group. Main outcome measures included demographic and outcome differences associated with trial participation. Health status of married women residing five communities in Nepal: unexpectedly high prevalence of anemia in a well-off community of Kathmandu. For patients with HCM and suspected coexistent CAD, this comprehensive cardiac CT protocol can be helpful in ruling out coronary stenosis and can provide information regarding morphology, function and tissue characterization of the LV myocardium. Using population data collected throughout Finland during 1986-2011, we analyse the spatio-temporal variation in the interactions between populations of voles and specialist, generalist and avian predators, and investigate by simulations the roles of the different predators in the vole cycle.

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Assessment of a parametric identification procedure of simple models for left ventricular afterload. It does this by regulating its expression of receptor activator of nuclear factor-kappa B ligand (RANKL), colony-stimulating factor-1 (CSF-1), and osteoprotegerin (OPG). Comparative analysis of the heat stable proteome of radicles of Medicago truncatula seeds during germination identifies late embryogenesis abundant proteins associated with desiccation tolerance. Preadipocyte factor-1 (Pref-1) has been shown to inhibit differentiation in adipocyte precursor cells and zebeta generic name could thereby play a role in determining adipocyte size, adipose tissue functioning, and metabolic profile in obese individuals. The study was designed as an observational chart and billing data review of current and proposed payments, in the setting of a preoperative holing area, intraoperative suite, and post anesthesia care unit. Accounting for anovulation and vaginal thinning during depot medroxyprogesterone acetate use. There was minimal loss of motion, a moderate cubitis valgus deformity, and a definite ulnar nerve palsy. This model should prove useful for understanding molecular mechanisms that underlie regeneration, and for identifying factors that promote RPE regeneration in age-related macular degeneration and related diseases.

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Clinical evaluation of rigid gas permeable contact lenses and visual outcome after repaired corneal laceration. In this article, we discuss Calu-3 as a model in light of our ongoing studies, which suggest that Calu-3 monolayers resemble submucosal glands more closely than was previously thought. We aimed to develop and assess the accuracy of a more efficient severity evaluation system, termed the Ugawa classification, using brain-type natriuretic peptide (BNP) measurement and the estimated glomerular filtration rate (eGFR). These results suggest that ceramide production by activation of neutral sphingomyelinase is an essential component of the TCR signaling machinery. Considering the potential morbidity of Schistosoma infections on the mothers, fetuses, and neonates, as evidenced in some animal models and human case studies, more attention is solicited in all areas of observational studies and clinical trials, for maternal schistosomiasis with the aim of providing relevant data and information for effective management of the disease during pregnancy. An early diagnosis and treatment of intraocular diseases is necessary to maintain an acceptable degree of quality of life. medicae WSM419 nodules showed increased sucrose-catabolic activity, mostly associated with sucrose synthase, accompanied by a reduced starch content, whereas nitrogen-assimilation activities were comparable to those measured in nodules infected with S. A comprehensive view of the epigenetic landscape part I: DNA methylation, passive and active DNA demethylation pathways and histone variants.

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Computed tomographic estimation of lung dimensions throughout the growth period. Further papers from the Twenty-first International Hospital Congress, Oslo. In the past 5-10 years, the power of the green fluorescent protein (GFP) and its numerous derivatives has been harnessed toward the development of genetically encoded fluorescent biosensors. It can be used for the target-directed isolation of these constituents. Retrospective cohort study of HCV-infected patients using data obtained from the national VA Hepatitis C Clinical Case Registry. We conducted a pharmacoeconomic analysis for estimating the cost per life-year gained using this drug.

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The main need, therefore, is to perform AIT clinical studies only in patients with asthma and following standardized protocols, as recommended by international Guidelines. Capillary Condensation of Associating Fluids in Slit-Like Pores: A Density Functional Theory. Site-specific protein immobilization using unnatural amino acids. The review deals with the problem of the detection of the causative agent of lepra in different biological samples with the use of polymerase chain reaction. Screening incarcerated women in Los Angeles County revealed a high prevalence of STIs and HIV. coli host strain, autoinduction medium, induction temperature, harvest time and cell lysis procedure to produce active recombinant GO. Staphylococcus intermedius has been isolated from healthy dogs and pigeons as well as diseased dogs.

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