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Adipine (Nifedipine)

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Adipine is a dihydropyridine calcium channel blocker. Adipine is used to: treat high blood pressure (hypertension), prevent chronic stable angina (chest pain). Adipine was the first calcium channel blocker to be shown to significantly reduce the development of new overt heart failure in patients with coronary artery disease. Excellent blood-pressure control in recent clinical trials has been shown to result in significant protection against stroke. Adipine works by opening up blood vessels in the body to lower blood pressure and improve the supply of blood and oxygen to the heart. Calcium channel blockers do not change the amount of calcium in your blood or bones.

Other names for this medication:
Afeditab, Amarkor, Antrolin, Aprical, Cardiosol, Casanmil, Chronadalate, Cobalat, Conducil, Conetrin, Coracten, Coral, Cordafen, Cordaflex, Cordipin, Corotrend, Depin, Ficard, Jutadilat, Nidicard, Nidilat, Nidipine, Nifecard, Nifedel, Nifedin, Nifedipina, Nifedipinum, Nifensar, Nifestad, Nifin, Nipidin, Noviken, Nycopin, Nyefax, Ospocard, Pressolat, Sidalat, Xepalat

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adipine OROS. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Adipine and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Adipine dosage information

Side effects

The most common side effects associated with Adipine are:

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A light and electron microscopic study using horseradish peroxidase as a tracer. If health service planners and policy makers could fill this gap, a considerable decline in the prevalence of unwanted pregnancy may be achieved by using EC. The purpose of the study was to evaluate the effects of maternal pre-pregnancy body mass index (BMI) and gestational weight gain on perinatal outcomes in a population of Korean women. A biopsy was recommended for masses that were increasing in size and changing in nature. The prevalence of EIB reported in this study is higher than that reported in studies from other African countries, with the exception of a study from Kenya. Matching morphine and beta-endorphin doses such that approximately equal submaximal submaximal effects occurred, it was observed that the antinociception produced by beta-endorphin lasted approximately three times longer than that produced by morphine. Contrary to expectations, both LTD and LTP induction trigger an increase in PIP3 synthesis, which requires NMDARs and PI3K activity. Recently, techniques from information theory have been brought to bear on this problem. An interactive PyMOL plugin permits drawing of the communication pathways between chosen protein fragments or residues on a 3D representation. At high levels of vitamin A and other retinoids (3 X 10(-6) M) attachment of human keratinocytes to 3T3-coated plastic dishes is mildly inhibited.

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Computerized material management, inventory control, and purchase orders in the clinical laboratory. Evidence suggests the role of neuroplasticity in these processes. A Rhodobacter sphaeroides puf L, M and X deletion mutant and its complementation in trans with a 5.3 kb puf operon shuttle fragment. The effects of methylphenidate on the lever-pressing of 12 mentally retarded children maintained under fixed-ratio 5, 10 and 20 schedules of food delivery were examined. Innovative testing of spatial ability: interactive responding and the use of complex stimuli material. The aim of the study was evaluation of three statins: simvastatin, atorvastatin and pravastatin on plasma lipidogram and fluidity of erythrocytes membranes in patients (pts) with hyperlipidemia (hlp) type II. Labeled HDL was displaced by corresponding unlabeled lipoproteins, but human LDL could produce only minor displacement of human HDL3.

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The aim of the present study was to assess the effects of IIT, with a focus on postoperative liver function, in hepatectomized patients. Progressive external ophthalmoplegia, retinal pigment degeneration and heart conduction disorders. This study compared RV longitudinal strain values of two different speckle tracking software technologies, velocity vector imaging (VVI) and two-dimensional speckle tracking echocardiography (2DSTE), and longitudinal strain by cardiac magnetic resonance (CMR). Common to all three groups with induced sadness were rCBF increases in the dorsal/rostral anterior cingulate and anterior insula and decreases in the orbitofrontal and inferior temporal cortices. Articles were selected based on accuracy and evidence in the scientific literature. Maintenance of self-incompatibility in peripheral populations of a circumboreal woodland subshrub.

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Content mixing and membrane integrity during membrane fusion driven by pairing of isolated v-SNAREs and t-SNAREs. The highest resolution vacuum ultraviolet photoabsorption spectrum of ethyl formate, C2H5OCHO, yet reported is presented over the wavelength range 115.0-275.5 nm (10.75-4.5 eV) revealing several new spectral features. Thus, tapasin acts as a chaperone and/or peptide editor that facilitates assembly of peptides with HLA class I molecules independently of mediating their interaction with TAP and/or retention in the endoplasmic reticulum. He presented with a huge right lower quadrant abdominal mass and marked eosinophilia. This paper describes the use of the new technique of computer testing to study the simulated performance of flat and curved pivoting disc prosthetic mitral valves. The primary structure of subunit II of NADH dehydrogenase from bovine-heart mitochondria. Fifty-eight consecutive, unselected patients underwent bowel decompression, resection and primary colocolic anastomosis.

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61 procedures with selective peripheral denervation for cervical dystonia were retrospectively analysed concerning surgical results, pain, quality of life (QoL) and recurrences. These preliminary results indicate that stimulation of the substantia nigra has a net excitatory effect on ACh synthesis in the caudate. Merlin reintroduction into schwannoma cells increased p53 levels and activity, and treatment with Nutlin-3, a drug which increases p53 stability by disrupting the p53/MDM2 complex, decreased tumour growth and reduced cell survival. Although indel frequency profiles have been used to construct profile-based variable gap penalties in some profile-profile alignment algorithms, there is still no fair comparison between variable gap penalties and traditional linear gap penalties to quantify the improvement of alignment accuracy. Neonatal screening and a new cause of congenital central hypothyroidism. The aim of this study was to characterize standard values for the opening pressure (ETOP), the opening frequency (ETOF), and the opening duration (ETOD) for active tubal openings (Valsalva maneuver, swallowing) in healthy participants.

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Clinic based interviews systematically exaggerate health status compared tricor medicine covid 19 with self assessment. These findings suggest that combining CM with bupropion for the treatment of cocaine addiction may significantly improve outcomes relative to bupropion alone. We searched Medline, Web of Science, Embase, and the Cochrane Database of Systematic Reviews to identify studies published in English between Jan 1, 1960, and April 30, 2014, which investigated antimalarial treatment efficacy in P. Filamentous actin (F-actin) and globular actin (G-actin) were quantified using confocal microscopy in PCAs with and without exposure to ONOO-. The ct-DNA studies suggest that the compounds also interacted with the DNA molecule itself, probably affecting template activity. It may be concluded that physiological level of thyroid hormones is an important modulator of the normal maturation of the beta-adrenergic system in the developing rat ventricular myocardium. Pregnancy-associated venous thromboembolism in combined heterozygous factor V Leiden and prothrombin G20210A mutations. We have for the first time shown that the terminal purine catabolite uric acid (UA) is elevated in wound fluid (WF) from chronic venous leg ulcers with relative concentrations correlating with wound chronicity. Counseling was least prevalent among the same groups of women with the highest rates for drinking. Similar results are observed with Thoc1/p84 and Rb1 gene therapy.

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Haemobilia secondary to a liver pseudoaneurysm after choledochostomy using noroxin dose a Kehr tube. Rural-based sonographers appear to have greater work stress related to waiting lists, use of outdated and non-adjustable equipment, and high client load. Besides demographic data, RA techniques used and the method of nerve location was questioned. HNP was measured by ELISA in bronchoalveolar lavage (BAL) fluid in lung transplant recipients. Patients with end-stage renal disease are known to suffer from chronic inflammation as the result of an ongoing subacute cytokine induction, which may contribute considerably to dialysis-related long-term morbidity and mortality.

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Waste anaesthetic gases induce sister chromatid exchanges in lymphocytes of operating room personnel. We examined the effects of LJ against H(2)O(2)-induced cytotoxicity, apoptosis, the production of reactive oxygen species (ROS), the proteolysis of cleaved poly-ADP-ribose polymerase (PARP), and the expression of Bcl-2, Bcl-xL, and cleaved caspase-3. 7-NINA alone did not affect these catecholamine secretion responses. Revisiting cycloid psychosis: a case of an acute, transient and recurring psychotic disorder. To alert the pediatric emergency physician about suppurative mediastinitis as an unusual, life-threatening complication of retropharyngeal abscesses in children and to report an alternative therapeutic option for these cases. Organization of the murine Ig-related lambda(5) gene transcribed selectively in pre-B lymphocytes. A prominent theory is that perivascular edema causes increased resistance at the lung bases and inverts the normal perfusion gradient such that upper lobe noroxin tablet blood flow exceeds lower lobe flow. Time-reversal symmetry breaking superconductivity in the coexistence phase with magnetism in Fe pnictides. The evolution of a new (unofficial) specialty: dental Geriatrician. Exposure to asbestos: correlation between blood levels of mesothelin and frequency of micronuclei in peripheral blood lymphocytes.

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In conclusion, the single intervention strategy of Schwann cell microimplantation is not sufficient to ensure regeneration of the subacutally or chronically transected postcommissural fornix. Descriptive statistics were computed for 100 secondary rhinoplasty patients, 50 of whom originally had dorsal humps, 21 of whom had straight, functional noses, and 29 of whom had subjectively normal noses but underwent multiple rhinoplasties. This poperty of hair cells is important for optical cochlear investigations. Taken together, these findings demonstrate the applicability of mammalian immune assays for predicting malathion-induced immunosuppression in a teleost fish, as well as the potential utility of a small laboratory fish to serve as an alternate model for mammals in immunotoxicological studies. Pretransition and main transition of aqueous dipalmitoyl phosphatidylcholine (DPPC) dispersions were investigated by pulse NMR. The binary or ternary combinations characterized by the highest coupling constants and the highest intensities are those involving the nu(OH), delta(OH), gamma(OH), and nu(C-O) vibrations. Increasing interest has focused on whether INSs, including MFNS, may have beneficial effects on the ocular symptoms frequently associated with AR. Fish-bone peptide increases calcium solubility and bioavailability in ovariectomised rats. Three groups of depressive patients ( cleocin ovules dosage endogenous bipolar, endogenous unipolar, and nonendogenous) and one nondepressive control group displayed statistically significant differences on several personality variables when the patients were in a depression-free interval. In an ecological study design, data from national databases were combined by record linkage.

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HNF1B polymorphism associated with development of prostate cancer in Korean patients. The outcomes reported in this paper clearly indicate a feasible experimental method to probe the activation of resonant electrodynamic interactions among biomolecules. Further research on this measure of forward propulsion may lead to the provision of an effective tool for distinguishing functional compensation from physiological restitution. Analysis of surgical versus medical therapy in active complicated native valve infective endocarditis. Here we asked whether c-Abl regulates the YAP-TEAD functional module. Editorial: fluid resuscitation in acute pancreatitis: striking the right balance. Therefore, the present study was designed to examine the effect of the KD on endogenous NO production, as well as the precise role of NO in kainic acid (KA)-induced seizures, in male ICR mice.

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Beneficial effects of melatonin receptor agonists on comorbid neurological, psychiatric, cardiovascular and metabolic symptomatology beyond sleep regulation are also described. After full implementation of the ban, cessation did not vary by brand variant. In the present study we investigated the relationship between MFS, SE and SRS, and evaluated whether the CHX-induced blockade of MFS was transient or permanent in nature. DksA appears to be involved in the expression of several genes in addition to rpoS based on two-dimensional SDS-PAGE analysis of whole-cell proteins. Intratumoral hypoxia fraction was evaluated by the immunohistochemical detection of hypoxic probe pimonidazole and carbonic anhydrase IX (CAIX). Cyclic movements were faster, had higher IP, showed fewer changes in velocity and were more ballistic. Surface glossiness is one of the important visual appearance parameters of natural polymer material (wood) and its related products. Mortality was higher following valve procedures than following coronary artery bypass operations in the early period.

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Hydrogen storage properties of isocyanide-stabilized palladium nanoparticles. Porous heterogeneous catalysts play a pivotal role in the chemical industry. These are complemented by the limitations in the representation of propositional knowledge, i.e. Elevated FSHR levels promoted EMT, migration, and invasion, whereas small interfering RNA-mediated FSHR is zyrtec generic or brand name knockdown inhibited these processes. Relevant articles were reviewed for quality assessment, data extraction and synthesis. Imported large subunits were associated with two distinct macromolecular structures.

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We present an experimental proposal for the generation of photon triplets based on third-order spontaneous parametric downconversion in thin chlorambucil dose dogs lymphoma optical fibers. Such poor behavioral self-regulation could also increase sensitivity to the disruptive effects of alcohol on driving performance. The importance of waist circumference in the definition of metabolic syndrome: prospective analyses of mortality in men. However, variables that predispose vulnerability have not been as clearly characterised. Glycolic acid (GA) has been widely used in cosmetic agents and superficial chemical peeling in recent years. Last, we discuss major limitations of currently available data and future directions in the field.

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We established a serum four-miRNA panel with considerable clinical value in the early-stage diagnosis of CAC. Thus the esterase from intestinal mucosa appears to be characteristically quite different from hepatic esterase. The present article reviews signaling pathways in melanocytes and alterations in melanoma that are a prerequisite to understanding modern cancer therapies in melanoma. For almost half a century, the field of mammalian Phylogeny has been dominated by a pessimistic view, according to which the great burst of mammalian radiations more than 65 million years ago has rendered the ordinal phylogeny of mammals insolvable. These data support the hypothesis that both intrinsic and extrinsic processes of neuromodulation mediate habituation and sensitization. Behaviour change counselling for ARV adherence support within primary health care facilities in the Western Cape, South Africa. Based on an assessment of the available research, this article uses syndemic theory to suggest the role of adverse bio-social interactions in increasing the total disease burden of tick-borne infections in local populations. Occupational biomechanical exposure predicts low back pain in older age among men in the Gazel Cohort. However, these data sets only cover less than the most recent 20 years and are insufficient for identifying decadal and longer periodic variabilities. Organ mercury levels in infants with omphaloceles treated with organic mercurial antiseptic.

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