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Adiff (Adapalene)

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Adiff is a third-generation topical retinoid primarily used in the treatment of mild-moderate acne, and is also used off-label to treat keratosis pilaris as well as other skin conditions. Among topical retinoids used to treat acne vulgaris, Adiff is considered to be the least effective, but best tolerated.

Other names for this medication:
Aclene, Acneril, Acneris, Acniriv, Acnovate, Adaferin, Adapalene, Adapen, Adaple, Adaret, Adgraze, Adiff, Adina, Aditop, Adlene, Alangel, Apalene, Apgel, Clinred, Daple, Deriva, Difra, Edplin, Faceclin, Labopene, Medapine, Rozac, Soflene, Vandep, Zolvee

Similar Products:
Rulide, Nizoral, Trandate, Amaryl, Bystolic, Ozolam, Albendazole, Pyras, Deplatt, Finlipol, Coronal,

Also known as: Adapalene


Adiff is a third-generation topical retinoid primarily used in the treatment of acne. Adiff is a gel used for the treatment of acne (blackheads, whiteheads and pimples) of the face, chest or back. Adiff gel is a clear gel that powers deep inside your pores to control the buildup that leads to acne. It helps prevent the formation of new acne lesions, and can also help get rid of lesions already present. Adiff works under the skin surface to unclog pores and clear up pimples. Adiff is also known as Adapalene, Adapen, Adaferin. Generic name of Adiff is Adapalene.


Follow the directions for using this medicine provided by your doctor. Use Adiff exactly as directed. Adiff is best applied after washing and drying your skin. Apply a thin layer of gel to the affected areas once daily at bedtime. Avoid the eyes, lips and nose. Do not allow this preparation to come into contact with the mucous membranes (e.g. mouth, vagina, inside of nose etc.). Try not to touch the treated areas overnight. Do not use any harsh soaps or exfoliants while you are being treated with Adiff. Adiff should not be used on broken, sunburnt or infected skin. You may notice a slight change of colour of the skin you are applying this preparation to. This is only temporary and should return to normal soon after finishing treatment with Adiff. Continue using Adiff until no new acne spots appear. You may need to use it for several months. You should notice some clinical improvement after 4-8 weeks and more improvement after further use. There may be a worsening of acne during the first few weeks of therapy because Adiff promotes the growth of pimples that have begun to form but are not yet visible. Therefore, treatment should not be stopped if acne appears to be worsening. Use a sunscreen cream and wear protective clothing if exposure to strong or prolonged sunlight cannot be avoided. Weather extremes such as wind or cold may also be irritating.


Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include skin redness, scaling, or irritation.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Detailed Adiff dosage information

Side effects

The most common side effects associated with Adiff are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Adiff if you are allergic to Adiff components. It is not known whether Adiff will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant or breast-feeding. Do not get Adiff in your eyes or on the inside of your nose or mouth. For the first 2 to 3 weeks of treatment, your skin condition may appear to worsen. This is expected. Do not stop using the medicine during this time. Do not use other medicines on your skin without first discussing it with your doctor. While you are using Adiff, you may use cosmetics. After using cosmetics, thoroughly wash and dry the affected area before applying this medicine. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Adiff. Use a sunscreen if you must be outside. Do not apply it to sunburned skin. Do not stop taking Adiff suddenly.

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A nasopharyngeal airway is useful in relieving postoperative airway obstruction. Subjects for this study were drawn from intern classes during the 2007-2008 and 2008-2009 academic years from 6 and 13 participating community and university hospitals, respectively. The mainstay of treatment should be wide surgical excision with long-term oncologic follow-up. Such a combination may be especially useful for heavily treated patients suffering from advanced tumor and requiring additional aggressive chemotherapy which, however, at that time could represent almost life-threatening way of medication. Race/ethnicity before and after adjustment for MICS, including values for body mass index, serum albumin, total iron-binding capacity, ferritin, creatinine, phosphorus, calcium, bicarbonate, white blood cell count, lymphocyte percentage, hemoglobin, and protein intake. Although further investigation is necessary to validate these pathways, there is potential for clinical application, particularly in the use of pharmacologic inhibitors of CXCR4 as means of preventing sarcoma metastasis. Tone-pips of 500, 1000, and 3000 Hz were presented at 0-, 10-, 20-, 35-, and 50-dB HL to 10 normal-hearing subjects and at 0-, 10-, 20-, 35-, and 50-dB SL to 10 subjects with conductive, sensorineural, or mixed hearing losses. Cough hypersensitivity syndrome: towards a new approach to chronic cough. Sporotrichosis, which is caused by the dimorphic fungus Sporothrix schenckii, is currently distributed throughout the world, especially in tropical and subtropical zones.

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The role of proteinases, and blockage of implantation by proteinase inhibitors. Efforts to regulate the collection and use of genetic information. Unimaginable violence in psychiatry--some reflections after a visit to Poland. AIDS and the law: why hospitals must protect workers against AIDS. Very high voltage rotation radiotherapy and significance of roentgen rays.

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Treatment of age-related macular degeneration with photodynamic therapy (TAP) Study Group. In contrast, central administration of DHT, 3beta-diol, and the ERbeta-selective compound diarylpropionitrile significantly decreased the corticosterone and ACTH response to immobilization. The themes were personal inefficacy with 6 subgroups included inadequate information, low age, curiosity, consideration of smoking not as a major problem, wrong beliefs, and making reasons. In recent years, the procedure of sacral hysteronpexy is gaining popularity. We present a primary transoral robotic surgery (TORS) for a laryngeal schwannoma and highlight the advantages of the robotic assistance. A preliminary evaluation of the Colorado RETHINK Parenting and Anger Management program. This analysis compared direct costs from the health plan perspective, including clinic visits, e-mail and telephone encounters, laboratory tests, medications, hospitalizations, and emergency department visits between the 2 groups.

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Serial fluorometric assessment of experimental neurovascular island flaps. This information may help to elucidate the link between BV and infection-related adverse outcomes of pregnancy. The implications of these findings for understanding the autistic language deficit are explored. The use of interviews appears to be a cost-effective method of determining oral morbidity. The high association with additional cardiovascular abnormalities in patients presenting in early infancy contributes significantly to the mortality. This study was performed to estimate the burden of CVID in Iran during 1985-2008 based on incidence, mortality, and disability-adjusted life-years (DALY). The continued and evolving nature of our understanding of the right ventricle was emphasized in 2006, when the National Heart, Blood, and Lung Institute biaxin 500 mg bid formed a working group focused on developing a better understanding of the right ventricle in both healthy and disease states. The regulation of energy homeostasis by thyroid hormones is unquestionable, and iodothyronine deiodinases are enzymes involved in the metabolic activation or inactivation of these hormones at the cellular level. The ribonuclease protection assay (RPA) represents a technology that allows detection of small amounts of intact RNA.

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This study investigates whether combination systemic and intravitreal antiviral therapy is superior to systemic antiviral therapy alone. In grafted cucumber rhizospheric soil, the microbial biomass C and N were significantly higher than those in self-rooted cucumber rhiaospheric soil, whereas the basal respiration and metabolic quotient were significantly lower. Evidence shows that many patients with fractures do not undergo appropriate assessment or treatment. Evidence is presented that the gut flora constitute the main source of acetate in blood of fed adult rats, though endogenous production of acetate is of significance in other situations. Paramagnetic capture mode magnetophoretic microseparator for high efficiency blood cell separations. In this study, the effects of oral doses of natural alpha-tocopherol (75, 200 and 400 IU/day) were studied in order to determine whether the same effects might be achieved with lower intakes of vitamin E and whether inhibition is related to the platelet levels of the antioxidant in platelet membranes. The primary synchronizing agents of the circadian system are light and melatonin. Balancing image quality and compression factor for special stains whole slide images. Various general surgical procedures have proved feasible and safe when performed with the da Vinci robot.

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