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Actispas (Ranitidine)

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Actispas is a histamine type 2 receptor antagonist (H2 blocker) which is widely used for treatment of acid-peptic disease and heartburn. Actispas has been linked to rare instances of clinically apparent acute liver injury.

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Also known as: Ranitidine


Actispas (ranitidine) belongs to a group of drugs called histamine-2 blockers. It works by reducing the amount of acid your stomach produces.

Actispas has been used to treat and prevent ulcers in the stomach and intestines. It also was used to treat conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome..

Actispas was also used to treat gastroesophageal reflux disease (GERD) and other conditions in which acid backs up from the stomach into the esophagus, causing heartburn.

A cancer-causing impurity found in many ranitidine medications may increase to unacceptable levels over time and when ranitidine is stored at high temperatures. As a result, the FDA has asked all makers of ranitidine to withdraw this medicine from the market in the United States.


Because Actispas has been withdrawn from the market in the U.S., some of the contents of this leaflet are intended for historical purposes only.

Take Actispas exactly as directed on the label, or as prescribed by your doctor.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

It may take up to 8 weeks before your ulcer heals. Keep using your medications as directed and call your doctor if your symptoms do not improve after 6 weeks.

Your doctor may recommend an antacid to help relieve pain. Carefully follow your doctor's directions about the type of antacid to use, and when to use it.

Store at room temperature away from moisture, heat, and light.

Detailed Actispas dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include lack of coordination, feeling light-headed, or fainting.


Store at room temperature between 2 and 30 degrees C (36 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Actispas are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


If you have been taking prescription-strength Actispas: Before you stop taking the medicine, ask your doctor about safer treatment options.

If you have been taking over-the-counter (OTC) Actispas: Stop taking the medicine, and ask your doctor or pharmacist about other approved OTC stomach acid reducers.

Heartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel anxious or light-headed.

Before using any OTC medicine to reduce stomach acid, ask a doctor or pharmacist if the medicine is safe for you if you have other medical conditions or allergies.

Ask a doctor before using any OTC stomach acid medicine if you are pregnant or breastfeeding.

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