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Abamune (Lamivudine)
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Abamune

Abamune once daily in combination with at least 2 other HIV ARVs for 28 days is a first-choice regimen for post-exposure prophlaxis (PEP) in people with kidney problems. PEP is used to prevent HIV infection in people who do not have HIV, and think they have been exposed to HIV. PEP must be started within 72 hours of the exposure.

Other names for this medication:
Abamune, Combivir, Emduo, Haptavir, Hepavud, Hepitec, Hepravir, Hivir, Ladiwin, Lamidac, Lamistar, Lamivir, Lamivox, Lamivudine, Lamostad, Lamuvid, Lavir, Lazid, Lmivir, Nevilast, Odivir, Retrolam, Shanvudin, Stadin, Stavex, Tenola, Tenolam, Tenvir, Trimune, Trioday, Viramid, Virolam, Virolis, Zidolam

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Also known as: Lamivudine

Description

Abamune (lamivudine) is an antiviral medicine that prevents human immunodeficiency virus (HIV) or hepatitis B virus from multiplying in your body.

Abamune is for treating HIV in adults and children at least 3 months old. HIV is the virus that can cause acquired immunodeficiency syndrome (AIDS). Lamivudine is not a cure for HIV or AIDS.

Abamune-HBV is for treating hepatitis B in adults and children at least 2 years old. It should not be used in people who are infected with both hepatitis B and HIV.

Dosage

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. You should not take Abamune (for treating HIV) together with Abamune-HBV (for treating hepatitis B).

You may take Abamune HBV with or without food.

Abamune HBV doses are based on weight in children. Your child's dose needs may change if the child gains or loses weight. Children who weigh more than 30 pounds (14 kilograms) should use the tablet form of lamivudine if possible. This medicine liquid may not be as effective.

You may need to break an Abamune tablet in half when giving Abamune HBV to a child for HIV. Call your doctor if the child has any trouble swallowing the tablet.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

The Abamune brand contains a higher dose of lamivudine than Abamune-HBV brand. Abamune is for treating HIV and Abamune-HBV is for treating hepatitis B. Each time you get a refill of this medication, be sure you have received the correct brand to treat your condition.

You will need frequent medical tests, including frequent HIV testing. If you become infected with HIV while you are taking Abamune HBV to treat hepatitis B, the HIV could become resistant to antiviral medicines if not treated right away.

The hepatitis B virus can mutate while you are taking Abamune-HBV and may become resistant to treatment. Resistant hepatitis B can lead to worsening liver disease or death. Tell your doctor if you have new or worsening hepatitis symptoms.

Use all HIV medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor's advice. Every person with HIV should remain under the care of a doctor.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

If you've ever had hepatitis B, this virus may become active or get worse in the months after you stop using Abamune HBV. You may need frequent liver function tests while using this medicine and for several months after your last dose.

Detailed Abamune-HBV dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Abamune are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not take Abamune HBV if you are allergic to it.

You should not take Abamune-HBV (for treating hepatitis B) if you also take other medicine that contains Abamune HBV or emtricitabine, which includes Atripla, Biktarvy, Cimduo, Combivir, Complera, Descovy, Emtriva, Epzicom, Genvoya, Odefsey, Stribild, Symfi, Triumeq, Trizivir, and Truvada.

Tell your doctor if you have ever had:

liver disease (especially hepatitis B or C, or a liver transplant); pancreatitis; kidney disease; or diabetes (liquid Abamune HBV contains 3 to 4 grams of sucrose per dose).

You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, if you've taken HIV medication for a long time, or if you are a woman. Ask your doctor about your risk.

Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.

You should not breastfeed while you are using Abamune HBV to treat hepatitis B. Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.

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